TLN1 and ITGA2B

Number of citations of the paper that reports this interaction (PMID 16546176)
1

Data Source:
HPRD (in vitro)

		TLN1	ITGA2B
Gene Name		talin 1	integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
Image
Gene Ontology Annotations	Cellular Component	Ruffle Extracellular Region Cytoplasm Microtubule Organizing Center Cytosol Plasma Membrane Cell-cell Junction Focal Adhesion Cell Surface Ruffle Membrane Extracellular Vesicular Exosome	Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Platelet Alpha Granule Membrane Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Insulin Receptor Binding Integrin Binding Structural Constituent Of Cytoskeleton Protein Binding Vinculin Binding LIM Domain Binding Actin Filament Binding	Protein Binding Identical Protein Binding Metal Ion Binding Extracellular Matrix Binding Fibrinogen Binding
	Biological Process	Platelet Degranulation Movement Of Cell Or Subcellular Component Muscle Contraction Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Cytoskeletal Anchoring At Plasma Membrane Cell-cell Junction Assembly Cell-substrate Junction Assembly Axon Guidance Blood Coagulation Platelet Activation Cortical Actin Cytoskeleton Organization Endoplasmic Reticulum Unfolded Protein Response Cellular Protein Metabolic Process Platelet Aggregation	Platelet Degranulation Positive Regulation Of Leukocyte Migration Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Axon Guidance Blood Coagulation Platelet Activation Extracellular Matrix Organization Platelet Aggregation
Pathways		Axon guidance Semaphorin interactions p130Cas linkage to MAPK signaling for integrins Smooth Muscle Contraction Integrin alphaIIb beta3 signaling Platelet degranulation GRB2:SOS provides linkage to MAPK signaling for Integrins Platelet Aggregation (Plug Formation) XBP1(S) activates chaperone genes IRE1alpha activates chaperones Response to elevated platelet cytosolic Ca2+ SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion Platelet activation, signaling and aggregation Unfolded Protein Response (UPR)	Signal transduction by L1 Axon guidance p130Cas linkage to MAPK signaling for integrins Integrin alphaIIb beta3 signaling L1CAM interactions Platelet degranulation GRB2:SOS provides linkage to MAPK signaling for Integrins Platelet Aggregation (Plug Formation) Response to elevated platelet cytosolic Ca2+ ECM proteoglycans Integrin cell surface interactions Platelet activation, signaling and aggregation
Drugs			Abciximab Tirofiban
Diseases
GWAS			Platelet counts ( 22139419)
Protein-Protein Interactions		23 interactors: ACTA1 CDK5 DAG1 EGFR ERBB2 ITGA1 ITGA2B ITGB1 ITGB2 ITGB3 ITGB5 ITGB7 LRP2 NRAP PKD1 PTK2 PTK2B PXN SMURF1 TES TUBA1A VCL YWHAQ	15 interactors: AUP1 CALR CAMK2A CD36 CIB1 CLNS1A COL1A2 COL2A1 F2 FGA GRB2 ITGB3 PRKACA TLN1 VWF
Entrez ID		7094	3674
HPRD ID		01726	06377
Ensembl ID		ENSG00000137076	ENSG00000005961
Uniprot IDs		Q9Y490	P08514
PDB IDs		1SYQ 4DJ9	1DPK 1DPQ 1JX5 1KUP 1KUZ 1M8O 1RN0 1S4W 1TYE 1UV9 2K1A 2K9J 2KNC 2VC2 2VDK 2VDL 2VDM 2VDN 2VDO 2VDP 2VDQ 2VDR 3FCS 3FCU 3NID 3NIF 3NIG 3T3M 3T3P 3ZDX 3ZDY 3ZDZ 3ZE0 3ZE1 3ZE2
Enriched GO Terms of Interacting Partners?		Cell-matrix Adhesion Cell-substrate Adhesion Integrin-mediated Signaling Pathway Movement Of Cell Or Subcellular Component Cell Adhesion Cell Morphogenesis Involved In Differentiation Anatomical Structure Morphogenesis Response To External Stimulus Cell Differentiation Axonogenesis Anatomical Structure Development Extracellular Matrix Organization Extracellular Structure Organization Axon Development Cell Morphogenesis Axon Guidance Cell Morphogenesis Involved In Neuron Differentiation Neuron Projection Development Regulation Of Cell Migration Chemotaxis Cell Development Cell Projection Organization Neuron Projection Morphogenesis Regulation Of Cell Motility Developmental Process Multicellular Organismal Development Positive Regulation Of Protein Kinase Activity Regulation Of Locomotion Locomotion Neuron Development Regulation Of Cellular Component Movement Positive Regulation Of Kinase Activity Positive Regulation Of Protein Phosphorylation Regulation Of Phosphorylation Single Organismal Cell-cell Adhesion Regulation Of Protein Phosphorylation Positive Regulation Of Transferase Activity Neuron Differentiation Cell Projection Morphogenesis Nervous System Development Regulation Of Phosphorus Metabolic Process Cell Part Morphogenesis Positive Regulation Of Phosphorylation Wound Healing Positive Regulation Of Protein Modification Process Generation Of Neurons Blood Coagulation Cellular Localization Hemostasis Heterotypic Cell-cell Adhesion	Platelet Activation Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Cell Activation Response To Wounding Platelet Degranulation Response To Stress Positive Regulation Of Phosphorylation Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Immune System Process Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Cell Adhesion Positive Regulation Of Protein Phosphorylation Positive Regulation Of Transport Leukocyte Migration Cellular Response To Organic Substance Cellular Component Assembly Regulation Of Blood Coagulation Positive Regulation Of Protein Modification Process Vesicle-mediated Transport Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Cell-substrate Adhesion Regulation Of Wound Healing Regulation Of Cell Adhesion Regulation Of Signaling Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Protein Phosphorylation Exocytosis Positive Regulation Of Cellular Protein Metabolic Process Platelet Aggregation Cell Adhesion Response To Organic Substance Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Locomotion Positive Regulation Of Signal Transduction Regulation Of Cell-substrate Adhesion Regulation Of Signal Transduction Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Protein Kinase Activity Cardiovascular System Development Positive Regulation Of Kinase Activity Negative Regulation Of Protein Metabolic Process Transport Secretion By Cell Movement Of Cell Or Subcellular Component
Tagcloud ?		83a adjacent brainstem clu comprehensive correlating dipg dipgs ef2 fresh frozen glioma h3f3a hedgehog hh hist1h3b hypomethylation morbid multidimensional pediatric pontine profiling ptch signatures specimens subgroups supervised talin upregulation	actively agilent altogether calmodulin cardiotonic circulation cldn16 downregulating eclampsia enkur esr1 fermt1 fltv3 grin2c hbmec interrogated marinobufagenin mbg microarrays microvascular monolayers permeability physiology preeclampsia sflt slc8a1 tmem207 transcriptomes vegfr
Tagcloud (Difference) ?		83a adjacent brainstem clu comprehensive correlating dipg dipgs ef2 fresh frozen glioma h3f3a hedgehog hh hist1h3b hypomethylation morbid multidimensional pediatric pontine profiling ptch signatures specimens subgroups supervised talin upregulation	actively agilent altogether calmodulin cardiotonic circulation cldn16 downregulating eclampsia enkur esr1 fermt1 fltv3 grin2c hbmec interrogated marinobufagenin mbg microarrays microvascular monolayers permeability physiology preeclampsia sflt slc8a1 tmem207 transcriptomes vegfr
Tagcloud (Intersection) ?