TLN1 and ARHGAP31

Number of citations of the paper that reports this interaction (PubMedID 35044719)
104

Data Source:
BioGRID (affinity chromatography technology, unspecified method)

		TLN1	ARHGAP31
Description		talin 1	Rho GTPase activating protein 31
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Extracellular Region Cytoplasm Cytosol Cytoskeleton Plasma Membrane Adherens Junction Focal Adhesion Cell Surface Membrane Ruffle Membrane Cell Projection Extracellular Exosome Anchoring Junction	Cytosol Focal Adhesion Lamellipodium Cell Projection Anchoring Junction
	Molecular Function	Phosphatidylserine Binding Actin Binding Integrin Binding Structural Constituent Of Cytoskeleton Protein Binding Vinculin Binding LIM Domain Binding Phosphatidylinositol Binding Cadherin Binding Actin Filament Binding	GTPase Activator Activity Protein Binding SH3 Domain Binding
	Biological Process	Cell-cell Junction Assembly Cell-substrate Junction Assembly Cell Adhesion Integrin-mediated Signaling Pathway Actin Cytoskeleton Organization Cortical Actin Cytoskeleton Organization Integrin Activation Cortical Microtubule Organization Regulation Of Focal Adhesion Assembly Platelet Aggregation Cell-cell Adhesion	Signal Transduction Small GTPase-mediated Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction
Pathways		Platelet degranulation Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins XBP1(S) activates chaperone genes SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion Smooth Muscle Contraction MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RHOU GTPase cycle
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) IgE levels in asthmatics ( 23967269) Lymphocyte count ( 32888494) Monocyte count ( 32888494) Platelet distribution width ( 27863252 32888494) Plateletcrit ( 32888494)	Celiac disease ( 22057235 30572963) Schizophrenia ( 23894747) Systemic sclerosis ( 31672989)
Interacting Genes		37 interacting genes: ABI1 ACTA1 ARHGAP31 AZIN2 CDK5 CEBPA DAG1 DOK1 EGFR ERBB2 FMO1 HSP90AA1 ITGA1 ITGA2B ITGB1 ITGB2 ITGB3 ITGB5 ITGB7 LRP2 MTNR1A MTNR1B NRAP NYAP1 PIP5K1C PKD1 PTK2 PTK2B PXN RET SMURF1 SUMO2 TES TPTE TUBA1A VCL YWHAQ	7 interacting genes: CDC42 ITSN1 RAC1 RHOA SMURF1 TGFBR1 TLN1
Entrez ID		7094	57514
HPRD ID		01726	16697
Ensembl ID		ENSG00000137076	ENSG00000031081
Uniprot IDs		Q9Y490	A0A8S0MHV1 Q2M1Z3
PDB IDs		1SYQ 2MWN 4DJ9 6R9T
Enriched GO Terms of Interacting Partners?		Focal Adhesion Cell-matrix Adhesion Cell-substrate Adhesion Integrin Complex Integrin-mediated Signaling Pathway Cell Migration Receptor Complex Cell Motility Cell Adhesion Cell-cell Adhesion Cell Surface Receptor Signaling Pathway Signal Transduction Cell Adhesion Mediated By Integrin Lamellipodium Enzyme-linked Receptor Protein Signaling Pathway Filopodium Virus Receptor Activity Regulation Of Protein Metabolic Process Cell Surface Anchoring Junction Cell Projection Symbiont Entry Into Host Cell Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Plasma Membrane Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Extracellular Exosome Signal Complex Assembly Developmental Process Integrin Binding Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of Protein Metabolic Process Heterotypic Cell-cell Adhesion Biological Process Involved In Interaction With Host Neuron Projection Morphogenesis Protein Phosphatase Binding Vinculin Binding Cell Projection Morphogenesis Cell Projection Organization Ruffle Membrane Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Wound Healing, Spreading Of Epidermal Cells Integrin Alpha1-beta1 Complex Regulation Of Cell Migration Positive Regulation Of Fibroblast Migration Regulation Of Apoptotic Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell Adhesion Anatomical Structure Morphogenesis Regulation Of Cell-matrix Adhesion Regulation Of Cell Development	Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Stress Fiber Assembly Membrane Invagination Non-canonical Wnt Signaling Pathway Positive Regulation Of Actin Filament Bundle Assembly Regulation Of Stress Fiber Assembly Cell-cell Junction Organization Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Cellular Component Organization Regulation Of Cell-substrate Adhesion Regulation Of Cellular Component Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Wnt Signaling Pathway Regulation Of Actin Filament Organization Regulation Of Focal Adhesion Assembly G Protein Activity Regulation Of Cell-substrate Junction Organization Regulation Of Modification Of Postsynaptic Actin Cytoskeleton G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Regulation Of Synapse Organization Regulation Of Actin Cytoskeleton Organization Ruffle Membrane Actin Cytoskeleton Organization Thioesterase Binding Positive Regulation Of Cell Projection Organization Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Actin Filament-based Process Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Focal Adhesion Regulation Of Cell-matrix Adhesion Regulation Of Modification Of Postsynaptic Structure Cell Surface Receptor Signaling Pathway Cell Junction Organization I-SMAD Binding Establishment Of Epithelial Cell Apical/basal Polarity Regulation Of Postsynapse Organization Supramolecular Fiber Organization Positive Regulation Of Organelle Organization Positive Regulation Of Cellular Component Biogenesis Regulation Of Modification Of Synaptic Structure Establishment Or Maintenance Of Cell Polarity Positive Regulation Of Cell Growth Regulation Of Cytoskeleton Organization GTP-dependent Protein Binding Establishment Of Apical/basal Cell Polarity Polarized Epithelial Cell Differentiation Positive Regulation Of Cell Migration
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