YWHAQ and UCP2

Number of citations of the paper that reports this interaction (PMID 10785390)
3

Data Source:
BioGRID (two hybrid)
HPRD (in vitro)

		YWHAQ	UCP2
Gene Name		tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta	uncoupling protein 2 (mitochondrial, proton carrier)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Focal Adhesion Membrane Cytoplasmic Vesicle Membrane Extracellular Vesicular Exosome	Mitochondrial Inner Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding Protein Domain Specific Binding Protein N-terminus Binding
	Biological Process	Protein Targeting Apoptotic Process Small GTPase Mediated Signal Transduction Substantia Nigra Development Negative Regulation Of Transcription, DNA-templated Membrane Organization Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway	Response To Superoxide Response To Hypoxia Transport Mitochondrial Transport Female Pregnancy Aging Positive Regulation Of Cell Death Proton Transport Respiratory Electron Transport Chain Cellular Response To Insulin Stimulus Cellular Response To Amino Acid Starvation Negative Regulation Of Apoptotic Process Cellular Metabolic Process Small Molecule Metabolic Process Regulation Of Mitochondrial Membrane Potential Negative Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Response To Fatty Acid Cellular Response To Glucose Stimulus Liver Regeneration
Pathways		Activation of BAD and translocation to mitochondria Programmed Cell Death Translocation of GLUT4 to the plasma membrane Activation of BH3-only proteins Intrinsic Pathway for Apoptosis	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. The proton buffering model Mitochondrial Uncoupling Proteins The fatty acid cycling model The citric acid (TCA) cycle and respiratory electron transport
Drugs
Diseases
GWAS		Heart rate variability traits ( 22174390)
Protein-Protein Interactions		231 interactors: AARS2 ABL1 ACSL4 AHCY AKT1S1 ANXA1 ANXA2 APC AR ARHGAP10 ARHGEF16 ATP5A1 BAD BAX BCAP31 BCR BRAF CABIN1 CAPN3 CBL CBLL1 CDC25A CDC25B CDC25C CDC5L CDK11B CDK14 CDK16 CDK17 CDK18 CDKN1A CDKN1B CEP170 CFL1 CHAF1A CKM CLTC COPS4 CSE1L CSNK1A1 CSNK2A1 CTPS1 DAB2IP DCPS DDX1 DDX3X DHX9 DISC1 DNMT1 DYNC1H1 E2F1 EFNB1 EIF4A3 ENO1 EPB41 EPB41L1 EPB41L3 ESR1 ESR2 EXO1 FASN FBLN1 FGR FSCN1 FSHR FXYD1 GAPDH GCN1L1 HADHA HAT1 HAX1 HDAC4 HDAC5 HDAC7 HIST1H2BG HIST2H4A HNRNPA1 HNRNPC HNRNPF HNRNPH1 HNRNPK HSPA1A HSPA8 HUS1 IARS2 ING1 IQGAP1 IRS2 ITGB4 KCNK15 KCNK3 KCNK9 KIAA1429 KIF1C KIF23 KIF5B KLC2 KLC3 KRT1 KRT9 LARP1 LARS2 LDHA LIMA1 LMNA LMNB1 LMO7 LYST MAGOH MAP3K3 MAP3K5 MARK2 MARK3 MCM3 MDM4 MED1 MEF2D MPL MPRIP MRPS27 MST1R MTNR1B MTOR MYCBP2 NADK NCL NCOA1 NCOA3 NDE1 NFATC1 NFATC2 NFATC4 NFKB1 NIF3L1 NME7 NOLC1 NUMA1 PABPC4 PABPN1 PAK4 PANK1 PCM1 PDCD6 PDE3A PDE3B PDK1 PDPK1 PDXK PFKFB2 PFKL PFN1 PGK1 PHLDB2 PI4KB PIK3C2B PIK3C3 PIK3CB PKM PPFIBP1 PRDX1 PRKCQ PRKCZ PRKD1 PRKDC PRMT5 PSME3 PTPN3 RAF1 RAI14 RCOR3 REM1 RFC1 RGS3 RGS7 RNASE2 RPL10A RPL15 RPL19 RPL7 RPLP0 RPLP2 RPS3 RUVBL2 SAMSN1 SH3BP2 SLC27A2 SLC8A1 SLC8A2 SLC8A3 SMAD9 SNRPE SPR SPTA1 SPTB SRSF3 SSBP1 SSFA2 SSX2IP TCP1 TERT THRA TLN1 TNF TNFAIP3 TP53BP2 TPI1 TPR TRIM28 TRIM42 TSC1 TSC2 TUBA1A TUBA3C TUBB UBQLN4 UCP2 UCP3 ULK4 USP8 VARS WDR61 WDR77 WEE1 WTAP WWC2 WWP1 YAP1 YWHAE YWHAG ZC3H13 ZHX2	6 interactors: KRTAP10-3 KRTAP10-7 YWHAB YWHAG YWHAQ YWHAZ
Entrez ID		10971	7351
HPRD ID		00886	03410
Ensembl ID		ENSG00000134308
Uniprot IDs		B4DMT8 P27348	P55851
PDB IDs		2BTP
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Cellular Metabolic Process Organelle Organization Cellular Process Cellular Response To Organic Substance Regulation Of Cellular Component Organization Response To Organic Substance Response To Stimulus Positive Regulation Of Cellular Metabolic Process Developmental Process Positive Regulation Of Metabolic Process Regulation Of Cell Death Mitotic Cell Cycle Regulation Of Metabolic Process Response To Stress Cell Cycle Cellular Response To Stimulus Mitotic Cell Cycle Process Death Regulation Of Apoptotic Process Programmed Cell Death Regulation Of Protein Localization Intracellular Signal Transduction Apoptotic Process Cell Cycle Process Anatomical Structure Development Cell Death Regulation Of Cellular Localization System Development Multicellular Organismal Development Regulation Of Establishment Of Protein Localization Negative Regulation Of Cellular Metabolic Process Regulation Of Cellular Process Regulation Of Cell Cycle Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Abiotic Stimulus Positive Regulation Of Protein Metabolic Process Intracellular Transport Regulation Of Signaling Nucleobase-containing Compound Metabolic Process Cellular Response To Stress Regulation Of Phosphorylation Innate Immune Response MRNA Metabolic Process Cellular Localization Immune System Process Regulation Of Kinase Activity	Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrion Organization Regulation Of Mitochondrion Organization Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Intracellular Transport Apoptotic Signaling Pathway Positive Regulation Of Organelle Organization Protein Targeting Regulation Of Intracellular Transport Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Establishment Of Protein Localization Positive Regulation Of Transport Regulation Of Protein Localization Membrane Organization Intracellular Protein Transport Regulation Of Organelle Organization Apoptotic Process Programmed Cell Death Regulation Of Cellular Localization Cell Death Death Positive Regulation Of Signal Transduction Cellular Protein Localization Protein Transport Regulation Of Apoptotic Process Establishment Of Protein Localization Intracellular Transport Regulation Of Cell Death Intracellular Signal Transduction Protein Localization Regulation Of Cellular Component Organization Establishment Of Localization In Cell Cellular Localization Regulation Of Signal Transduction Regulation Of Signaling Cellular Response To Insulin Stimulus Golgi Reassembly Response To Insulin Negative Regulation Of Protein Dephosphorylation Histamine Secretion By Mast Cell Cellular Response To Peptide Hormone Stimulus Establishment Of Golgi Localization Cellular Response To Peptide Golgi Inheritance Histamine Secretion
Tagcloud ?			1s adipocyte adipose ap2 bip carbonylation chop concomitant enigmatic equilibrium fabp fabp4 fatty ffa herein hts01037 indirectly lipopolysaccharide macrophages negated null palmitate pharmacologic r126q ucp1 ucp3 uncouples uncoupling xbp
Tagcloud (Difference) ?			1s adipocyte adipose ap2 bip carbonylation chop concomitant enigmatic equilibrium fabp fabp4 fatty ffa herein hts01037 indirectly lipopolysaccharide macrophages negated null palmitate pharmacologic r126q ucp1 ucp3 uncouples uncoupling xbp
Tagcloud (Intersection) ?