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TLN1 and TUBA1A
Number of citations of the paper that reports this interaction (PubMedID
18341635
)
0
Data Source:
BioGRID
(fluorescent resonance energy transfer)
TLN1
TUBA1A
Description
talin 1
tubulin alpha 1a
Image
GO Annotations
Cellular Component
Ruffle
Extracellular Region
Cytoplasm
Cytosol
Cytoskeleton
Plasma Membrane
Adherens Junction
Focal Adhesion
Cell Surface
Membrane
Ruffle Membrane
Cell Projection
Extracellular Exosome
Anchoring Junction
Condensed Chromosome
Nucleus
Cytoplasm
Cytosol
Cytoskeleton
Microtubule
Axonemal Microtubule
Cytoplasmic Microtubule
Plasma Membrane
Cilium
Microtubule Cytoskeleton
Motile Cilium
Neuromuscular Junction
Sperm Flagellum
Cytoplasmic Ribonucleoprotein Granule
Cell Projection
Synapse
Recycling Endosome
Extracellular Exosome
Molecular Function
Phosphatidylserine Binding
Actin Binding
Integrin Binding
Structural Constituent Of Cytoskeleton
Protein Binding
Vinculin Binding
LIM Domain Binding
Phosphatidylinositol Binding
Cadherin Binding
Actin Filament Binding
Nucleotide Binding
Structural Molecule Activity
Structural Constituent Of Cytoskeleton
Protein Binding
GTP Binding
Hydrolase Activity
Identical Protein Binding
Protein-containing Complex Binding
Metal Ion Binding
Protein Heterodimerization Activity
Biological Process
Cell-cell Junction Assembly
Cell-substrate Junction Assembly
Cell Adhesion
Integrin-mediated Signaling Pathway
Actin Cytoskeleton Organization
Cortical Actin Cytoskeleton Organization
Integrin Activation
Cortical Microtubule Organization
Regulation Of Focal Adhesion Assembly
Platelet Aggregation
Cell-cell Adhesion
Microtubule Cytoskeleton Organization
Mitotic Cell Cycle
Neuron Migration
Startle Response
Intracellular Protein Transport
Microtubule-based Process
Centrosome Cycle
Smoothened Signaling Pathway
Memory
Locomotory Behavior
Adult Locomotory Behavior
Visual Learning
Response To Mechanical Stimulus
Glial Cell Differentiation
Gene Expression
Dentate Gyrus Development
Cerebellar Cortex Morphogenesis
Hippocampus Development
Pyramidal Neuron Differentiation
Cerebral Cortex Development
Neurogenesis
Neuron Differentiation
Flagellated Sperm Motility
Adult Behavior
Cytoskeleton-dependent Intracellular Transport
Response To Tumor Necrosis Factor
Locomotory Exploration Behavior
Microtubule Polymerization
Forebrain Morphogenesis
Homeostasis Of Number Of Cells Within A Tissue
Regulation Of Synapse Organization
Synapse Organization
Cell Division
Neuron Apoptotic Process
Motor Behavior
Cellular Response To Calcium Ion
Organelle Transport Along Microtubule
Neuron Projection Arborization
Response To L-glutamate
Pathways
Platelet degranulation
Integrin signaling
GRB2:SOS provides linkage to MAPK signaling for Integrins
p130Cas linkage to MAPK signaling for integrins
XBP1(S) activates chaperone genes
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
Smooth Muscle Contraction
MAP2K and MAPK activation
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF1 fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane
Gap junction assembly
MHC class II antigen presentation
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
Regulation of PLK1 Activity at G2/M Transition
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Prefoldin mediated transfer of substrate to CCT/TriC
Formation of tubulin folding intermediates by CCT/TriC
Post-chaperonin tubulin folding pathway
Recycling pathway of L1
Recycling pathway of L1
Hedgehog 'off' state
Anchoring of the basal body to the plasma membrane
Cargo trafficking to the periciliary membrane
Intraflagellar transport
RHO GTPases activate IQGAPs
RHO GTPases Activate Formins
COPI-mediated anterograde transport
COPI-dependent Golgi-to-ER retrograde traffic
COPI-independent Golgi-to-ER retrograde traffic
Mitotic Prometaphase
The role of GTSE1 in G2/M progression after G2 checkpoint
AURKA Activation by TPX2
Carboxyterminal post-translational modifications of tubulin
Carboxyterminal post-translational modifications of tubulin
HCMV Early Events
Assembly and cell surface presentation of NMDA receptors
Activation of AMPK downstream of NMDARs
Aggrephagy
Aggrephagy
EML4 and NUDC in mitotic spindle formation
Sealing of the nuclear envelope (NE) by ESCRT-III
Kinesins
PKR-mediated signaling
Drugs
Albendazole
Vinblastine
Mebendazole
Epothilone D
Patupilone
CYT997
2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE
Artenimol
Phenethyl Isothiocyanate
Colchiceine
Diseases
Lissencephaly (LIS); Miller-Dieker syndrome (MDLS)
GWAS
Brain morphology (MOSTest) (
32665545
)
IgE levels in asthmatics (
23967269
)
Lymphocyte count (
32888494
)
Monocyte count (
32888494
)
Platelet distribution width (
27863252
32888494
)
Plateletcrit (
32888494
)
Brain morphology (MOSTest) (
32665545
)
Composite immunoglobulin trait (IgG/IgM) (
28628107
)
Interacting Genes
37 interacting genes:
ABI1
ACTA1
ARHGAP31
AZIN2
CDK5
CEBPA
DAG1
DOK1
EGFR
ERBB2
FMO1
HSP90AA1
ITGA1
ITGA2B
ITGB1
ITGB2
ITGB3
ITGB5
ITGB7
LRP2
MTNR1A
MTNR1B
NRAP
NYAP1
PIP5K1C
PKD1
PTK2
PTK2B
PXN
RET
SMURF1
SUMO2
TES
TPTE
TUBA1A
VCL
YWHAQ
66 interacting genes:
ANXA7
ARL3
ATXN3
B4GALT1
BTG1
C8orf33
CDKN1A
CDKN2A
CEP20
CLIP1
CNP
CPEB2
CXCR1
CYLD
DAG1
DUSP23
EGFR
EIF4ENIF1
EML1
ENO1
GEMIN7
GRM7
GSK3B
GZMB
HTRA2
KEL
KPNB1
LINC01554
LRRK2
MAP7D3
MAPK6
MAPRE1
MAX
MX1
MYC
NFATC1
NUDT3
OGT
PAFAH1B1
PGK1
PLA2G7
PLK2
S100A8
S100A9
SDC3
SIAH1
SMN1
SNCA
SOCS6
SOCS7
SPART
STARD13
STK11
SYK
SYTL4
TAOK2
TIMM17A
TK1
TLN1
TTR
TUBB
UBE2D3
VAV1
VCL
YWHAQ
ZAP70
Entrez ID
7094
7846
HPRD ID
01726
03959
Ensembl ID
ENSG00000137076
ENSG00000167552
Uniprot IDs
Q9Y490
Q71U36
PDB IDs
1SYQ
2MWN
4DJ9
6R9T
5JCO
6J8F
6WSL
7C1M
7UN1
7UNG
8J07
8SH7
Enriched GO Terms of Interacting Partners
?
Focal Adhesion
Cell-matrix Adhesion
Cell-substrate Adhesion
Integrin Complex
Integrin-mediated Signaling Pathway
Cell Migration
Receptor Complex
Cell Motility
Cell Adhesion
Cell-cell Adhesion
Cell Surface Receptor Signaling Pathway
Signal Transduction
Cell Adhesion Mediated By Integrin
Lamellipodium
Enzyme-linked Receptor Protein Signaling Pathway
Filopodium
Virus Receptor Activity
Regulation Of Protein Metabolic Process
Cell Surface
Anchoring Junction
Cell Projection
Symbiont Entry Into Host Cell
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Plasma Membrane
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Extracellular Exosome
Signal Complex Assembly
Developmental Process
Integrin Binding
Anatomical Structure Formation Involved In Morphogenesis
Positive Regulation Of Protein Metabolic Process
Heterotypic Cell-cell Adhesion
Biological Process Involved In Interaction With Host
Neuron Projection Morphogenesis
Protein Phosphatase Binding
Vinculin Binding
Cell Projection Morphogenesis
Cell Projection Organization
Ruffle Membrane
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Wound Healing, Spreading Of Epidermal Cells
Integrin Alpha1-beta1 Complex
Regulation Of Cell Migration
Positive Regulation Of Fibroblast Migration
Regulation Of Apoptotic Process
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Regulation Of Cell Adhesion
Anatomical Structure Morphogenesis
Regulation Of Cell-matrix Adhesion
Regulation Of Cell Development
Cytoplasm
Cytosol
Regulation Of Cell Growth
Intracellular Signaling Cassette
Microtubule Binding
Regulation Of Growth
Microtubule Cytoskeleton Organization
Intracellular Signal Transduction
Regulation Of Cellular Component Organization
Organelle Organization
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Positive Regulation Of Programmed Cell Death
Protein-containing Complex
Regulation Of Signal Transduction
Positive Regulation Of Signal Transduction
Cytoskeleton
Positive Regulation Of Cell Communication
Regulation Of Cell Communication
Kinase Activity
Positive Regulation Of Signaling
Regulation Of Signaling
Protein Metabolic Process
Regulation Of Developmental Process
Regulation Of Intrinsic Apoptotic Signaling Pathway
Myeloid Leukocyte Migration
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Negative Regulation Of Signal Transduction
Cell Migration
Neutrophil Chemotaxis
Developmental Process
Cytoplasmic Microtubule
Microtubule-based Process
Ubiquitin Protein Ligase Binding
Catabolic Process
Leukocyte Migration
Protein Serine/threonine Kinase Activity
Protein Kinase Activity
Tubulin Binding
Negative Regulation Of Cell Growth
Cytoskeleton Organization
Neutrophil Migration
Protein Localization To Nucleus
Cellular Developmental Process
Microtubule Cytoskeleton
Microtubule
Positive Regulation Of Apoptotic Process
Leukocyte Aggregation
Regulation Of Microtubule-based Process
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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