YWHAQ and PRKCZ

Number of citations of the paper that reports this interaction (PubMedID 10620507)
56

Data Source:
BioGRID (affinity chromatography technology, pull down, enzymatic study)

		YWHAQ	PRKCZ
Description		tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta	protein kinase C zeta
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Focal Adhesion Membrane Protein-containing Complex Synapse Extracellular Exosome	Nucleus Nuclear Envelope Cytoplasm Endosome Microtubule Organizing Center Cytosol Plasma Membrane Cell-cell Junction Bicellular Tight Junction Cilium Cell Cortex Membrane Apical Plasma Membrane Nuclear Matrix Cell Junction Vesicle Myelin Sheath Abaxonal Region Ciliary Basal Body Axon Hillock Apical Cortex Extracellular Exosome Tight Junction Anchoring Junction PAR Polarity Complex
	Molecular Function	Protein Binding Protein Domain Specific Binding Identical Protein Binding Transmembrane Transporter Binding 14-3-3 Protein Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Insulin Receptor Substrate Binding Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Protein Targeting Signal Transduction Small GTPase-mediated Signal Transduction Intracellular Protein Localization Substantia Nigra Development Negative Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of DNA-templated Transcription	Microtubule Cytoskeleton Organization Protein Phosphorylation Inflammatory Response Signal Transduction Establishment Of Cell Polarity Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Interleukin-5 Production Cellular Response To Insulin Stimulus Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of T-helper 2 Cell Differentiation Negative Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Long-term Synaptic Potentiation Positive Regulation Of ERK1 And ERK2 Cascade Protein Localization To Plasma Membrane Neuron Projection Extension Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of T-helper 2 Cell Cytokine Production
Pathways		Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane RHO GTPases activate PKNs TP53 Regulates Metabolic Genes Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Regulation of localization of FOXO transcription factors SARS-CoV-1 targets host intracellular signalling and regulatory pathways SARS-CoV-2 targets host intracellular signalling and regulatory pathways	GPVI-mediated activation cascade TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) VEGFR2 mediated cell proliferation RHO GTPases Activate NADPH Oxidases Estrogen-stimulated signaling through PRKCZ Estrogen-stimulated signaling through PRKCZ
Drugs		Phenethyl Isothiocyanate	Tamoxifen Staurosporine Dequalinium Benzoyl peroxide
Diseases
GWAS		Heart rate variability traits ( 22174390) Non-response to selective serotonin reuptake inhibitors and depression ( 27622933)	Body mass index ( 26426971) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) General risk tolerance (MTAG) ( 30643258) Height ( 20881960) Response to antipsychotic treatment in schizophrenia (reasoning) ( 21107309) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		216 interacting genes: AARS2 ABL1 ACSL4 ADRB2 AGTR1 AHCY AKT1S1 ANXA1 ANXA2 AR ARHGAP10 ARHGEF16 ATP5F1A BAD BAX BCAP31 BCR BRAF CABIN1 CAPN3 CBL CBLL1 CCDC125 CDC25A CDC25B CDC25C CDC5L CDK11B CDK14 CDK16 CDKN1A CDKN1B CFL1 CHAF1A CKM CLTC COPS4 CSE1L CSNK1A1 CSNK2A1 CTPS1 DAB2IP DCPS DDX1 DDX3X DHX9 DISC1 DNMT1 DYNC1H1 E2F1 EFNB1 EGFR EIF4A3 ENO1 EPB41 EPB41L1 EPB41L3 ESR1 ESR2 FASN FBLN1 FGR FSCN1 FSHR FXYD1 GAPDH GCN1 H2BC8 H4C14 HADHA HAT1 HAX1 HDAC7 HNRNPC HNRNPH1 HSPA1A HSPA8 HSPB1 HUS1 IARS2 ING1 ITCH ITGB4 KANK1 KCNK15 KCNK3 KCNK9 KIF5B KLC2 KLC3 KRT1 KRT9 LARP1 LARS2 LDHA LIMA1 LMNA LMNB1 LYST MAGOH MAP3K3 MAP3K5 MCM3 MDM4 MED1 MEF2D MPL MPRIP MRPS27 MST1R MTNR1B MTOR MYCBP2 NADK NCL NCOA1 NCOA3 NDE1 NEDD4L NFATC1 NFATC2 NFATC4 NFKB1 NIF3L1 NME7 NOLC1 NUMA1 PABPN1 PANK1 PDCD6 PDE3A PDE3B PDE4B PDK1 PDPK1 PDXK PFKFB2 PFKL PFN1 PGK1 PHLDB2 PI4KB PIK3C3 PIK3CB PKM PRDX1 PRKCQ PRKCZ PRKD1 PRKDC PRMT5 PSME3 RAI14 RCOR3 REM1 RFC1 RGS3 RGS7 RIPK2 RNASE2 RPL10A RPL15 RPL19 RPL7 RPLP0 RPLP2 RPS3 RUVBL2 SAMSN1 SH3BP2 SKIC8 SLC27A2 SLC8A1 SLC8A2 SLC8A3 SMAD9 SNRPE SOCS3 SPR SPTA1 SPTB SRSF3 SSBP1 SSX2IP SUMO2 TCP1 TERT THRA TLN1 TNF TNFAIP3 TPI1 TPR TRAF6 TRIM25 TRIM28 TRIM42 TSC1 TSC2 TUBA1A TUBA3C TUBB UBQLN4 UCP2 UCP3 ULK4 USP8 VARS1 WDR77 WTAP WWC2 WWP1 YAP1 YWHAG ZC3H13 ZHX2	91 interacting genes: ADAP1 ADCY5 AFAP1 AKT1 AKT3 BLVRA BTK C1QBP CASP3 CASP6 CASP7 CASP8 CASP9 CDC42 CHAT CREBBP CSNK2B DAPK3 DENND5A EGFR FADD FEZ1 FEZ2 FRS2 FYN GABARAP GLRX3 GRB14 GRM5 GSK3A GSK3B H1-1 H1-5 HABP4 HDAC6 HRAS IKBKB IL4R IRAK1 IRS1 IRS4 JAK1 KRT10 LRRK2 MAP1LC3B MAP2K1 MAP2K5 MAPK1 MAPK3 MAPK7 MAPT MBP NCF1 NCL NCOA3 NFATC2 NMT2 NUMB PARD6A PARD6B PARD6G PAWR PDLIM7 PDPK1 PEBP1 PIAS4 PPP1R14A PPP3CA PRG2 PRKCA PRKCD PSEN1 RAF1 RELA RHOA SLC39A1 SP1 SQSTM1 SRC STAT6 STUB1 TIAM1 TRAF6 UBC UTP14A VMA22 WWC1 YWHAB YWHAQ YWHAZ ZNF71
Entrez ID		10971	5590
HPRD ID		00886	01504
Ensembl ID		ENSG00000134308	ENSG00000067606
Uniprot IDs		P27348	Q05513
PDB IDs		2BTP 5IQP 6BCR 6BD2 6BQT 6KZG 6KZH
Enriched GO Terms of Interacting Partners?		Cytosol Cytoplasm Regulation Of Signaling Regulation Of Cell Communication Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Multicellular Organismal Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Protein Metabolic Process ATP Binding Regulation Of Cellular Component Organization Regulation Of Primary Metabolic Process Negative Regulation Of Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Regulation Of Programmed Cell Death Positive Regulation Of Metabolic Process Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of Metabolic Process Nucleus Cadherin Binding Kinase Activity Negative Regulation Of Programmed Cell Death Regulation Of Developmental Process Nucleobase-containing Compound Metabolic Process Cellular Response To Stress Nucleotide Binding Regulation Of Biological Quality Regulation Of Macromolecule Metabolic Process Positive Regulation Of Protein Metabolic Process Cell Cortex Cellular Response To Oxygen-containing Compound Response To Stress Protein-containing Complex Glucose Catabolic Process Organelle Organization Positive Regulation Of Multicellular Organismal Process Macromolecule Metabolic Process ADP Metabolic Process RNA Binding Cellular Response To Lipid Positive Regulation Of Cell Communication Positive Regulation Of Signaling Extracellular Exosome Regulation Of Organelle Organization Positive Regulation Of Cell Population Proliferation Glycolytic Process Cellular Response To Hormone Stimulus	Cytosol Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Signal Transduction Signal Transduction Intracellular Signaling Cassette Regulation Of Intracellular Signal Transduction Cytoplasm Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Signaling Negative Regulation Of Signal Transduction Regulation Of Apoptotic Process Regulation Of Multicellular Organismal Process Regulation Of Programmed Cell Death Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of Cell Communication Positive Regulation Of Signal Transduction Regulation Of Cellular Localization Enzyme-linked Receptor Protein Signaling Pathway Insulin Receptor Signaling Pathway Protein Kinase Activity Protein Phosphorylation Regulation Of Protein Metabolic Process Positive Regulation Of Immune System Process Regulation Of Cell Adhesion Regulation Of Immune Response Positive Regulation Of Protein Metabolic Process Regulation Of Protein Localization Positive Regulation Of Cell Migration Phosphorylation Regulation Of Cell-cell Adhesion Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Motility Response To Lipid Positive Regulation Of Multicellular Organismal Process Cellular Response To Oxygen-containing Compound Regulation Of Immune System Process Positive Regulation Of Locomotion Regulation Of Cell Migration Activation Of Immune Response Regulation Of Locomotion Kinase Activity Apoptotic Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Intracellular Signal Transduction Response To Stress
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