TLN1 and PKD1

Number of citations of the paper that reports this interaction (PubMedID 11113628)
0

Data Source:
HPRD (in vitro, in vivo)

		TLN1	PKD1
Description		talin 1	polycystin 1, transient receptor potential channel interacting
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GO Annotations	Cellular Component	Ruffle Extracellular Region Cytoplasm Cytosol Cytoskeleton Plasma Membrane Adherens Junction Focal Adhesion Cell Surface Membrane Ruffle Membrane Cell Projection Extracellular Exosome Anchoring Junction	Golgi Membrane Polycystin Complex Extracellular Region Nucleus Cytoplasm Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Cilium Cell Surface Membrane Basolateral Plasma Membrane Lateral Plasma Membrane Golgi-associated Vesicle Membrane Motile Cilium Vesicle Cation Channel Complex Calcium Channel Complex Cell Projection Ciliary Membrane Extracellular Exosome Migrasome
	Molecular Function	Phosphatidylserine Binding Actin Binding Integrin Binding Structural Constituent Of Cytoskeleton Protein Binding Vinculin Binding LIM Domain Binding Phosphatidylinositol Binding Cadherin Binding Actin Filament Binding	Monoatomic Cation Channel Activity Calcium Channel Activity Protein Binding Protein Kinase Binding Protein Domain Specific Binding Carbohydrate Binding Wnt Receptor Activity Transmembrane Transporter Binding Transcription Regulator Inhibitor Activity
	Biological Process	Cell-cell Junction Assembly Cell-substrate Junction Assembly Cell Adhesion Integrin-mediated Signaling Pathway Actin Cytoskeleton Organization Cortical Actin Cytoskeleton Organization Integrin Activation Cortical Microtubule Organization Regulation Of Focal Adhesion Assembly Platelet Aggregation Cell-cell Adhesion	Cartilage Condensation Blood Vessel Development In Utero Embryonic Development Kidney Development Liver Development Embryonic Placenta Development Protein Export From Nucleus Calcium Ion Transport Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cell-matrix Adhesion Calcium-independent Cell-matrix Adhesion Cell Surface Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell Surface Receptor Signaling Pathway Via JAK-STAT Heart Development Anatomical Structure Morphogenesis Animal Organ Morphogenesis Regulation Of Gene Expression Regulation Of Cell Cycle Process Wnt Signaling Pathway Spinal Cord Development Neural Tube Development Establishment Of Cell Polarity Regulation Of Cell Adhesion Response To Fluid Shear Stress Lymph Vessel Morphogenesis Chordate Embryonic Development Skin Development Positive Regulation Of Transcription By RNA Polymerase II Digestive Tract Development Branching Morphogenesis Of An Epithelial Tube Genitalia Development Detection Of Mechanical Stimulus Cartilage Development Protein Heterotetramerization Regulation Of Cell Cycle Regulation Of Mitotic Spindle Organization Lung Epithelium Development Placenta Blood Vessel Development Regulation Of Proteasomal Protein Catabolic Process Calcium Ion Transmembrane Transport Nitrogen Cycle Metabolic Process Mesonephric Tubule Development Mesonephric Duct Development Metanephric Collecting Duct Development Metanephric Ascending Thin Limb Development Metanephric Proximal Tubule Development Metanephric Distal Tubule Morphogenesis Cell-cell Adhesion Mitocytosis Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Platelet degranulation Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins XBP1(S) activates chaperone genes SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion Smooth Muscle Contraction MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	VxPx cargo-targeting to cilium VxPx cargo-targeting to cilium
Drugs
Diseases			Polycystic kidney disease
GWAS		Brain morphology (MOSTest) ( 32665545) IgE levels in asthmatics ( 23967269) Lymphocyte count ( 32888494) Monocyte count ( 32888494) Platelet distribution width ( 27863252 32888494) Plateletcrit ( 32888494)	Appendicular lean mass ( 33097823) Dilated cardiomyopathy ( 33677556) Estimated glomerular filtration rate ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Heel bone mineral density ( 30598549) Height ( 28552196) High light scatter reticulocyte count ( 32888494) Hypertrophic cardiomyopathy (MTAG) ( 33495596) Low hand grip strength (60 years and older) (EWGSOP) ( 33510174) Major depressive disorder ( 29317602) Neutrophil count ( 32888494) Systolic blood pressure ( 30578418) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		37 interacting genes: ABI1 ACTA1 ARHGAP31 AZIN2 CDK5 CEBPA DAG1 DOK1 EGFR ERBB2 FMO1 HSP90AA1 ITGA1 ITGA2B ITGB1 ITGB2 ITGB3 ITGB5 ITGB7 LRP2 MTNR1A MTNR1B NRAP NYAP1 PIP5K1C PKD1 PTK2 PTK2B PXN RET SMURF1 SUMO2 TES TPTE TUBA1A VCL YWHAQ	31 interacting genes: ACTN1 ATF7IP BCAR1 CDH1 COL1A1 COL2A1 CTNNA1 CTNNB1 DES FN1 HDAC9 JAK2 JUP KRT18 KRT8 LTB4R2 MARK2 NCF1 NCK2 PIP5K1C PKD2 PTK2 PTPRG PXN RGS7 RUNX1 SIAH1 SRC TLN1 VCL VIM
Entrez ID		7094	5310
HPRD ID		01726	03203
Ensembl ID		ENSG00000137076	ENSG00000008710
Uniprot IDs		Q9Y490	P98161
PDB IDs		1SYQ 2MWN 4DJ9 6R9T	1B4R 6A70
Enriched GO Terms of Interacting Partners?		Focal Adhesion Cell-matrix Adhesion Cell-substrate Adhesion Integrin Complex Integrin-mediated Signaling Pathway Cell Migration Receptor Complex Cell Motility Cell Adhesion Cell-cell Adhesion Cell Surface Receptor Signaling Pathway Signal Transduction Cell Adhesion Mediated By Integrin Lamellipodium Enzyme-linked Receptor Protein Signaling Pathway Filopodium Virus Receptor Activity Regulation Of Protein Metabolic Process Cell Surface Anchoring Junction Cell Projection Symbiont Entry Into Host Cell Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Plasma Membrane Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Extracellular Exosome Signal Complex Assembly Developmental Process Integrin Binding Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of Protein Metabolic Process Heterotypic Cell-cell Adhesion Biological Process Involved In Interaction With Host Neuron Projection Morphogenesis Protein Phosphatase Binding Vinculin Binding Cell Projection Morphogenesis Cell Projection Organization Ruffle Membrane Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Wound Healing, Spreading Of Epidermal Cells Integrin Alpha1-beta1 Complex Regulation Of Cell Migration Positive Regulation Of Fibroblast Migration Regulation Of Apoptotic Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell Adhesion Anatomical Structure Morphogenesis Regulation Of Cell-matrix Adhesion Regulation Of Cell Development	Anchoring Junction Focal Adhesion Cell-cell Junction Cellular Response To Indole-3-methanol Cell Junction Assembly Response To Indole-3-methanol Cell Surface Receptor Signaling Pathway Cell Migration Fascia Adherens Regulation Of Cell Adhesion Signal Complex Assembly Cell Adhesion Cell Motility Epidermal Growth Factor Receptor Signaling Pathway Adherens Junction Vinculin Binding Cell-cell Junction Assembly ERBB Signaling Pathway Regulation Of Cell Motility Cadherin Binding Regulation Of Cell-substrate Adhesion Cellular Response To Oxygen-containing Compound Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Locomotion Cell Junction Organization Integrin-mediated Signaling Pathway Cell-cell Junction Organization Regulation Of Cell Migration Extrinsic Apoptotic Signaling Pathway Plasma Membrane Plasma Membrane Bounded Cell Projection Organization Cytoskeleton Catenin Complex Signal Transduction Zonula Adherens Scaffold Protein Binding Flotillin Complex Cellular Response To Fluid Shear Stress Neuron Projection Development Alpha-catenin Binding Supramolecular Fiber Organization Cell-cell Adhesion Intermediate Filament Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Cell-cell Adhesion Cell-substrate Junction Assembly Cell-substrate Junction Organization Cytoplasm Anatomical Structure Morphogenesis Response To Fluid Shear Stress
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