YWHAQ and DAB2IP

Number of citations of the paper that reports this interaction (PubMedID 17389591)
0

Data Source:
BioGRID (pull down, affinity chromatography technology)

		YWHAQ	DAB2IP
Description		tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta	DAB2 interacting protein
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Focal Adhesion Membrane Protein-containing Complex Synapse Extracellular Exosome	Cytoplasm Cytosol Plasma Membrane Membrane Endocytic Vesicle Axon Dendrite Neuronal Cell Body Membrane Cell Projection Neuronal Cell Body Cerebellar Mossy Fiber Climbing Fiber Parallel Fiber AIP1-IRE1 Complex
	Molecular Function	Protein Binding Protein Domain Specific Binding Identical Protein Binding Transmembrane Transporter Binding 14-3-3 Protein Binding	GTPase Activator Activity Death Receptor Binding Protein Binding SH3 Domain Binding Kinase Binding Protein Kinase Binding Mitogen-activated Protein Kinase Kinase Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Phosphatidylinositol-3-phosphate Binding Signaling Adaptor Activity Toll-like Receptor 4 Binding Phosphatidylinositol 3-kinase Regulatory Subunit Binding Identical Protein Binding Protein Homodimerization Activity Vascular Endothelial Growth Factor Receptor 2 Binding Protein Serine/threonine Kinase Activator Activity Phosphatidylinositol 3-kinase Binding Protein-containing Complex Binding Cadherin Binding Protein Phosphatase 2A Binding Phosphatidylinositol-4-phosphate Binding 14-3-3 Protein Binding
	Biological Process	Protein Targeting Signal Transduction Small GTPase-mediated Signal Transduction Intracellular Protein Localization Substantia Nigra Development Negative Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of DNA-templated Transcription	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Immune System Process Apoptotic Process Inflammatory Response Response To Unfolded Protein Negative Regulation Of Cell Population Proliferation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Epithelial Cell Migration Negative Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Neuron Projection Development Negative Regulation Of Angiogenesis Cell Motility Involved In Cerebral Cortex Radial Glia Guided Migration Layer Formation In Cerebral Cortex Protein Catabolic Process Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein-containing Complex Assembly Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Negative Regulation Of GTPase Activity Cellular Response To Unfolded Protein Tube Formation Intracellular Signal Transduction Cellular Response To Vascular Endothelial Growth Factor Stimulus Vascular Endothelial Growth Factor Receptor-2 Signaling Pathway Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Protein Catabolic Process Positive Regulation Of Apoptotic Process Regulation Of GTPase Activity Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Protein-containing Complex Assembly Negative Regulation Of MAPK Cascade Positive Regulation Of MAPK Cascade Innate Immune Response Positive Regulation Of Protein Catabolic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Fibroblast Proliferation Neuron Projection Morphogenesis Negative Regulation Of Epithelial Cell Proliferation Regulation Of Cell Cycle Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Negative Regulation Of G0 To G1 Transition Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Epidermal Growth Factor Stimulus Endothelial Cell Apoptotic Process Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Synapse Maturation Lipid Droplet Formation Positive Regulation Of Dendrite Development Regulation Of P38MAPK Cascade Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of IRE1-mediated Unfolded Protein Response Positive Regulation Of Neuron Migration Positive Regulation Of Apoptotic Signaling Pathway
Pathways		Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane RHO GTPases activate PKNs TP53 Regulates Metabolic Genes Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Regulation of localization of FOXO transcription factors SARS-CoV-1 targets host intracellular signalling and regulatory pathways SARS-CoV-2 targets host intracellular signalling and regulatory pathways	Regulation of RAS by GAPs
Drugs		Phenethyl Isothiocyanate
Diseases
GWAS		Heart rate variability traits ( 22174390) Non-response to selective serotonin reuptake inhibitors and depression ( 27622933)	Abdominal aortic aneurysm ( 20622881 27899403) Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) ( 23648065) Appendicular lean mass ( 33097823) Arterial stiffness index ( 31235810) Coronary artery disease ( 33020668 32469254 29212778) Femur bone mineral density x serum urate levels interaction ( 34046847) Heart rate ( 23534349) Hip index ( 34021172) Metabolite levels ( 23823483) Metabolite levels (X-11787) ( 23934736) Myocardial infarction ( 33532862) Periodontal microbiota ( 22699663) Squamous cell lung carcinoma ( 31326317) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) vWF levels ( 30586737) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		216 interacting genes: AARS2 ABL1 ACSL4 ADRB2 AGTR1 AHCY AKT1S1 ANXA1 ANXA2 AR ARHGAP10 ARHGEF16 ATP5F1A BAD BAX BCAP31 BCR BRAF CABIN1 CAPN3 CBL CBLL1 CCDC125 CDC25A CDC25B CDC25C CDC5L CDK11B CDK14 CDK16 CDKN1A CDKN1B CFL1 CHAF1A CKM CLTC COPS4 CSE1L CSNK1A1 CSNK2A1 CTPS1 DAB2IP DCPS DDX1 DDX3X DHX9 DISC1 DNMT1 DYNC1H1 E2F1 EFNB1 EGFR EIF4A3 ENO1 EPB41 EPB41L1 EPB41L3 ESR1 ESR2 FASN FBLN1 FGR FSCN1 FSHR FXYD1 GAPDH GCN1 H2BC8 H4C14 HADHA HAT1 HAX1 HDAC7 HNRNPC HNRNPH1 HSPA1A HSPA8 HSPB1 HUS1 IARS2 ING1 ITCH ITGB4 KANK1 KCNK15 KCNK3 KCNK9 KIF5B KLC2 KLC3 KRT1 KRT9 LARP1 LARS2 LDHA LIMA1 LMNA LMNB1 LYST MAGOH MAP3K3 MAP3K5 MCM3 MDM4 MED1 MEF2D MPL MPRIP MRPS27 MST1R MTNR1B MTOR MYCBP2 NADK NCL NCOA1 NCOA3 NDE1 NEDD4L NFATC1 NFATC2 NFATC4 NFKB1 NIF3L1 NME7 NOLC1 NUMA1 PABPN1 PANK1 PDCD6 PDE3A PDE3B PDE4B PDK1 PDPK1 PDXK PFKFB2 PFKL PFN1 PGK1 PHLDB2 PI4KB PIK3C3 PIK3CB PKM PRDX1 PRKCQ PRKCZ PRKD1 PRKDC PRMT5 PSME3 RAI14 RCOR3 REM1 RFC1 RGS3 RGS7 RIPK2 RNASE2 RPL10A RPL15 RPL19 RPL7 RPLP0 RPLP2 RPS3 RUVBL2 SAMSN1 SH3BP2 SKIC8 SLC27A2 SLC8A1 SLC8A2 SLC8A3 SMAD9 SNRPE SOCS3 SPR SPTA1 SPTB SRSF3 SSBP1 SSX2IP SUMO2 TCP1 TERT THRA TLN1 TNF TNFAIP3 TPI1 TPR TRAF6 TRIM25 TRIM28 TRIM42 TSC1 TSC2 TUBA1A TUBA3C TUBB UBQLN4 UCP2 UCP3 ULK4 USP8 VARS1 WDR77 WTAP WWC2 WWP1 YAP1 YWHAG ZC3H13 ZHX2	6 interacting genes: AKT1 DAB1 DAB2 MAP3K5 SMARCA2 YWHAQ
Entrez ID		10971	153090
HPRD ID		00886	09903
Ensembl ID		ENSG00000134308	ENSG00000136848
Uniprot IDs		P27348	Q5VWQ8
PDB IDs		2BTP 5IQP 6BCR 6BD2 6BQT 6KZG 6KZH
Enriched GO Terms of Interacting Partners?		Cytosol Cytoplasm Regulation Of Signaling Regulation Of Cell Communication Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Multicellular Organismal Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Protein Metabolic Process ATP Binding Regulation Of Cellular Component Organization Regulation Of Primary Metabolic Process Negative Regulation Of Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Regulation Of Programmed Cell Death Positive Regulation Of Metabolic Process Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of Metabolic Process Nucleus Cadherin Binding Kinase Activity Negative Regulation Of Programmed Cell Death Regulation Of Developmental Process Nucleobase-containing Compound Metabolic Process Cellular Response To Stress Nucleotide Binding Regulation Of Biological Quality Regulation Of Macromolecule Metabolic Process Positive Regulation Of Protein Metabolic Process Cell Cortex Cellular Response To Oxygen-containing Compound Response To Stress Protein-containing Complex Glucose Catabolic Process Organelle Organization Positive Regulation Of Multicellular Organismal Process Macromolecule Metabolic Process ADP Metabolic Process RNA Binding Cellular Response To Lipid Positive Regulation Of Cell Communication Positive Regulation Of Signaling Extracellular Exosome Regulation Of Organelle Organization Positive Regulation Of Cell Population Proliferation Glycolytic Process Cellular Response To Hormone Stimulus	Positive Regulation Of Cell Differentiation Positive Regulation Of Developmental Process Negative Regulation Of Cell Projection Organization Regulation Of Cell Adhesion Regulation Of Cell Differentiation 14-3-3 Protein Binding Positive Regulation Of Steroid Biosynthetic Process Intracellular Signaling Cassette Positive Regulation Of Steroid Metabolic Process Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Myoblast Differentiation Response To Epidermal Growth Factor Cellular Response To Amino Acid Starvation Response To Amino Acid Starvation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Developmental Process Regulation Of Steroid Biosynthetic Process Regulation Of Cell Growth Regulation Of Neuron Projection Development Regulation Of TRNA Methylation Cell-cell Adhesion Involved In Neuronal-glial Interactions Involved In Cerebral Cortex Radial Glia Guided Migration Regulation Of Myoblast Differentiation Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Protein Localization To Endoplasmic Reticulum Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Growth Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Response To Insulin-like Growth Factor Stimulus Regulation Of DNA-templated Transcription Mammalian Oogenesis Stage Regulation Of Ketone Metabolic Process Nervous System Development Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Cell Adhesion TRNA (guanine-N7)-methylation Response To Tumor Necrosis Factor Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Lipid Transport Cellular Response To Rapamycin Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Lipid Metabolic Process Positive Regulation Of Lipid Biosynthetic Process Negative Regulation Of Protein Localization To Lysosome Positive Regulation Of Endodeoxyribonuclease Activity Cellular Response To Tumor Necrosis Factor
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