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YWHAQ and CSNK1A1
Number of citations of the paper that reports this interaction (PMID
9360956
)
19
Data Source:
HPRD
(in vitro)
YWHAQ
CSNK1A1
Gene Name
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
casein kinase 1, alpha 1
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Cytoplasm
Cytosol
Focal Adhesion
Membrane
Cytoplasmic Vesicle Membrane
Extracellular Vesicular Exosome
Condensed Chromosome Kinetochore
Cytoplasm
Centrosome
Cytosol
MRNA Cleavage And Polyadenylation Specificity Factor Complex
Membrane
Nuclear Speck
Primary Cilium
Molecular Function
Protein Binding
Protein Domain Specific Binding
Protein N-terminus Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Biological Process
Protein Targeting
Apoptotic Process
Small GTPase Mediated Signal Transduction
Substantia Nigra Development
Negative Regulation Of Transcription, DNA-templated
Membrane Organization
Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Protein Phosphorylation
Phagocytosis
Mitotic Nuclear Division
Signal Transduction
Cell Surface Receptor Signaling Pathway
Regulation Of Cell Shape
Wnt Signaling Pathway
Peptidyl-serine Phosphorylation
Cell Division
Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways
Activation of BAD and translocation to mitochondria
Programmed Cell Death
Translocation of GLUT4 to the plasma membrane
Activation of BH3-only proteins
Intrinsic Pathway for Apoptosis
Hedgehog 'off' state
misspliced GSK3beta mutants stabilize beta-catenin
APC truncation mutants have impaired AXIN binding
T41 mutants of beta-catenin aren't phosphorylated
TCF7L2 mutants don't bind CTBP
truncated APC mutants destabilize the destruction complex
Signaling by Wnt
APC truncation mutants are not K63 polyubiquitinated
disassembly of the destruction complex and recruitment of AXIN to the membrane
S37 mutants of beta-catenin aren't phosphorylated
Degradation of beta-catenin by the destruction complex
RNF mutants show enhanced WNT signaling and proliferation
AXIN mutants destabilize the destruction complex, activating WNT signaling
S33 mutants of beta-catenin aren't phosphorylated
Hedgehog 'on' state
XAV939 inhibits tankyrase, stabilizing AXIN
Beta-catenin phosphorylation cascade
truncations of AMER1 destabilize the destruction complex
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
AXIN missense mutants destabilize the destruction complex
S45 mutants of beta-catenin aren't phosphorylated
deletions in the AMER1 gene destabilize the destruction complex
TCF dependent signaling in response to WNT
AMER1 mutants destabilize the destruction complex
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
Signaling by Hedgehog
Signaling by WNT in cancer
GLI3 is processed to GLI3R by the proteasome
Degradation of GLI2 by the proteasome
Activation of SMO
Drugs
Diseases
GWAS
Heart rate variability traits (
22174390
)
Esophageal cancer (
21642993
)
Protein-Protein Interactions
231 interactors:
AARS2
ABL1
ACSL4
AHCY
AKT1S1
ANXA1
ANXA2
APC
AR
ARHGAP10
ARHGEF16
ATP5A1
BAD
BAX
BCAP31
BCR
BRAF
CABIN1
CAPN3
CBL
CBLL1
CDC25A
CDC25B
CDC25C
CDC5L
CDK11B
CDK14
CDK16
CDK17
CDK18
CDKN1A
CDKN1B
CEP170
CFL1
CHAF1A
CKM
CLTC
COPS4
CSE1L
CSNK1A1
CSNK2A1
CTPS1
DAB2IP
DCPS
DDX1
DDX3X
DHX9
DISC1
DNMT1
DYNC1H1
E2F1
EFNB1
EIF4A3
ENO1
EPB41
EPB41L1
EPB41L3
ESR1
ESR2
EXO1
FASN
FBLN1
FGR
FSCN1
FSHR
FXYD1
GAPDH
GCN1L1
HADHA
HAT1
HAX1
HDAC4
HDAC5
HDAC7
HIST1H2BG
HIST2H4A
HNRNPA1
HNRNPC
HNRNPF
HNRNPH1
HNRNPK
HSPA1A
HSPA8
HUS1
IARS2
ING1
IQGAP1
IRS2
ITGB4
KCNK15
KCNK3
KCNK9
KIAA1429
KIF1C
KIF23
KIF5B
KLC2
KLC3
KRT1
KRT9
LARP1
LARS2
LDHA
LIMA1
LMNA
LMNB1
LMO7
LYST
MAGOH
MAP3K3
MAP3K5
MARK2
MARK3
MCM3
MDM4
MED1
MEF2D
MPL
MPRIP
MRPS27
MST1R
MTNR1B
MTOR
MYCBP2
NADK
NCL
NCOA1
NCOA3
NDE1
NFATC1
NFATC2
NFATC4
NFKB1
NIF3L1
NME7
NOLC1
NUMA1
PABPC4
PABPN1
PAK4
PANK1
PCM1
PDCD6
PDE3A
PDE3B
PDK1
PDPK1
PDXK
PFKFB2
PFKL
PFN1
PGK1
PHLDB2
PI4KB
PIK3C2B
PIK3C3
PIK3CB
PKM
PPFIBP1
PRDX1
PRKCQ
PRKCZ
PRKD1
PRKDC
PRMT5
PSME3
PTPN3
RAF1
RAI14
RCOR3
REM1
RFC1
RGS3
RGS7
RNASE2
RPL10A
RPL15
RPL19
RPL7
RPLP0
RPLP2
RPS3
RUVBL2
SAMSN1
SH3BP2
SLC27A2
SLC8A1
SLC8A2
SLC8A3
SMAD9
SNRPE
SPR
SPTA1
SPTB
SRSF3
SSBP1
SSFA2
SSX2IP
TCP1
TERT
THRA
TLN1
TNF
TNFAIP3
TP53BP2
TPI1
TPR
TRIM28
TRIM42
TSC1
TSC2
TUBA1A
TUBA3C
TUBB
UBQLN4
UCP2
UCP3
ULK4
USP8
VARS
WDR61
WDR77
WEE1
WTAP
WWC2
WWP1
YAP1
YWHAE
YWHAG
ZC3H13
ZHX2
43 interactors:
ACTB
ADAP1
AP3B1
AP3B2
APC
AXIN1
BID
CDC25A
CHRM3
CREM
CTNNB1
EIF2B5
ERF
FADD
GLI3
GNB2
HMGB1
HMGB2
HNRNPC
HSPA4
KPNA2
KPNB1
LGALS3
MAPT
MDM4
NFATC3
PARK2
PDE4D
PHLPP1
PPP1CC
PPP1R14A
PPP2R5A
PSEN2
RCC1
SLC18A2
SNCA
SYT9
TGFBR1
TIAM1
TNFRSF1B
TP53
YWHAQ
YWHAZ
Entrez ID
10971
1452
HPRD ID
00886
02739
Ensembl ID
ENSG00000134308
ENSG00000113712
Uniprot IDs
B4DMT8
P27348
B4DER9
P48729
Q6PJ06
Q71TU5
PDB IDs
2BTP
Enriched GO Terms of Interacting Partners
?
Regulation Of Protein Metabolic Process
Regulation Of Cellular Protein Metabolic Process
Cellular Metabolic Process
Organelle Organization
Cellular Process
Cellular Response To Organic Substance
Regulation Of Cellular Component Organization
Response To Organic Substance
Response To Stimulus
Positive Regulation Of Cellular Metabolic Process
Developmental Process
Positive Regulation Of Metabolic Process
Regulation Of Cell Death
Mitotic Cell Cycle
Regulation Of Metabolic Process
Response To Stress
Cell Cycle
Cellular Response To Stimulus
Mitotic Cell Cycle Process
Death
Regulation Of Apoptotic Process
Programmed Cell Death
Regulation Of Protein Localization
Intracellular Signal Transduction
Apoptotic Process
Cell Cycle Process
Anatomical Structure Development
Cell Death
Regulation Of Cellular Localization
System Development
Multicellular Organismal Development
Regulation Of Establishment Of Protein Localization
Negative Regulation Of Cellular Metabolic Process
Regulation Of Cellular Process
Regulation Of Cell Cycle
Cellular Nitrogen Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Response To Abiotic Stimulus
Positive Regulation Of Protein Metabolic Process
Intracellular Transport
Regulation Of Signaling
Nucleobase-containing Compound Metabolic Process
Cellular Response To Stress
Regulation Of Phosphorylation
Innate Immune Response
MRNA Metabolic Process
Cellular Localization
Immune System Process
Regulation Of Kinase Activity
Death
Apoptotic Process
Programmed Cell Death
Cell Death
Cellular Response To Stimulus
Regulation Of Cellular Localization
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Signaling
Positive Regulation Of Cell Death
Response To Organic Substance
Response To Stimulus
Cell Communication
Regulation Of Apoptotic Process
Response To Stress
Regulation Of Cell Death
Regulation Of Protein Localization
Cellular Component Disassembly Involved In Execution Phase Of Apoptosis
Regulation Of Cellular Process
Regulation Of Signaling
Positive Regulation Of Apoptotic Signaling Pathway
Negative Regulation Of Apoptotic Process
Negative Regulation Of Programmed Cell Death
Regulation Of Intracellular Transport
Execution Phase Of Apoptosis
Response To External Stimulus
Negative Regulation Of Cellular Metabolic Process
Regulation Of Metabolic Process
Negative Regulation Of Cell Death
Immune System Process
Regulation Of Signal Transduction
Cell Surface Receptor Signaling Pathway
Cell Activation
Regulation Of Establishment Of Protein Localization
Developmental Process
Thymus Development
Regulation Of Catalytic Activity
Signal Transduction
Cellular Response To Organic Substance
Positive Regulation Of Metabolic Process
Positive Regulation Of Mitochondrion Organization
Regulation Of Protein Metabolic Process
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
T Cell Differentiation In Thymus
Regulation Of Cellular Component Organization
Regulation Of Protein Complex Assembly
Regulation Of Cellular Protein Metabolic Process
Leukocyte Activation
Positive Regulation Of Protein Metabolic Process
Movement Of Cell Or Subcellular Component
Tagcloud
?
aberrantly
antagonistic
beauty
becomes
canonical
concert
connectivity
ctnnb1
decipher
discover
facts
functioning
gbm
gli2
hedgehog
imperative
integrative
interplay
missed
ranked
recapitulate
relying
shh
similarities
smo
solve
sonic
surmised
wnt
Tagcloud (Difference)
?
aberrantly
antagonistic
beauty
becomes
canonical
concert
connectivity
ctnnb1
decipher
discover
facts
functioning
gbm
gli2
hedgehog
imperative
integrative
interplay
missed
ranked
recapitulate
relying
shh
similarities
smo
solve
sonic
surmised
wnt
Tagcloud (Intersection)
?