YWHAQ and ANXA1

Number of citations of the paper that reports this interaction (PMID 15161933)
63

Data Source:
BioGRID (pull down)

		YWHAQ	ANXA1
Gene Name		tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta	annexin A1
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Focal Adhesion Membrane Cytoplasmic Vesicle Membrane Extracellular Vesicular Exosome	Cornified Envelope Extracellular Region Extracellular Space Nucleus Cytoplasm Endosome Plasma Membrane Focal Adhesion Cilium Cell Surface Basolateral Plasma Membrane Mitochondrial Membrane Vesicle Sarcolemma Mast Cell Granule Protein Complex Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Protein Domain Specific Binding Protein N-terminus Binding	Single-stranded DNA Binding Single-stranded RNA Binding Helicase Activity Receptor Binding Structural Molecule Activity Calcium Ion Binding Protein Binding Phospholipid Binding Calcium-dependent Phospholipid Binding Phospholipase A2 Inhibitor Activity Protein Binding, Bridging Double-stranded DNA-dependent ATPase Activity Annealing Helicase Activity Protein Homodimerization Activity Calcium-dependent Protein Binding
	Biological Process	Protein Targeting Apoptotic Process Small GTPase Mediated Signal Transduction Substantia Nigra Development Negative Regulation Of Transcription, DNA-templated Membrane Organization Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway	DNA Strand Renaturation Neutrophil Homeostasis Movement Of Cell Or Subcellular Component Inflammatory Response Signal Transduction Cell Surface Receptor Signaling Pathway Response To X-ray Peptide Cross-linking Insulin Secretion Keratinocyte Differentiation Prostate Gland Development Endocrine Pancreas Development Positive Regulation Of Vesicle Fusion Positive Regulation Of Prostaglandin Biosynthetic Process Response To Estradiol DNA Duplex Unwinding Positive Regulation Of Neutrophil Apoptotic Process DNA Rewinding Gliogenesis Regulation Of Cell Proliferation Response To Drug Negative Regulation Of Apoptotic Process Response To Peptide Hormone Alpha-beta T Cell Differentiation Arachidonic Acid Secretion Cellular Response To Hydrogen Peroxide Hepatocyte Differentiation Prolactin Secretion Response To Interleukin-1 Cellular Response To Glucocorticoid Stimulus Neutrophil Clearance Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Phospholipase A2 Activity Negative Regulation Of Interleukin-8 Secretion
Pathways		Activation of BAD and translocation to mitochondria Programmed Cell Death Translocation of GLUT4 to the plasma membrane Activation of BH3-only proteins Intrinsic Pathway for Apoptosis	G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Class A/1 (Rhodopsin-like receptors) GPCR ligand binding Metabolic disorders of biological oxidation enzymes Formyl peptide receptors bind formyl peptides and many other ligands G alpha (q) signalling events GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK G alpha (i) signalling events
Drugs			Amcinonide Hydrocortisone Dexamethasone
Diseases
GWAS		Heart rate variability traits ( 22174390)	Schizophrenia, bipolar disorder and depression (combined) ( 20713499)
Protein-Protein Interactions		231 interactors: AARS2 ABL1 ACSL4 AHCY AKT1S1 ANXA1 ANXA2 APC AR ARHGAP10 ARHGEF16 ATP5A1 BAD BAX BCAP31 BCR BRAF CABIN1 CAPN3 CBL CBLL1 CDC25A CDC25B CDC25C CDC5L CDK11B CDK14 CDK16 CDK17 CDK18 CDKN1A CDKN1B CEP170 CFL1 CHAF1A CKM CLTC COPS4 CSE1L CSNK1A1 CSNK2A1 CTPS1 DAB2IP DCPS DDX1 DDX3X DHX9 DISC1 DNMT1 DYNC1H1 E2F1 EFNB1 EIF4A3 ENO1 EPB41 EPB41L1 EPB41L3 ESR1 ESR2 EXO1 FASN FBLN1 FGR FSCN1 FSHR FXYD1 GAPDH GCN1L1 HADHA HAT1 HAX1 HDAC4 HDAC5 HDAC7 HIST1H2BG HIST2H4A HNRNPA1 HNRNPC HNRNPF HNRNPH1 HNRNPK HSPA1A HSPA8 HUS1 IARS2 ING1 IQGAP1 IRS2 ITGB4 KCNK15 KCNK3 KCNK9 KIAA1429 KIF1C KIF23 KIF5B KLC2 KLC3 KRT1 KRT9 LARP1 LARS2 LDHA LIMA1 LMNA LMNB1 LMO7 LYST MAGOH MAP3K3 MAP3K5 MARK2 MARK3 MCM3 MDM4 MED1 MEF2D MPL MPRIP MRPS27 MST1R MTNR1B MTOR MYCBP2 NADK NCL NCOA1 NCOA3 NDE1 NFATC1 NFATC2 NFATC4 NFKB1 NIF3L1 NME7 NOLC1 NUMA1 PABPC4 PABPN1 PAK4 PANK1 PCM1 PDCD6 PDE3A PDE3B PDK1 PDPK1 PDXK PFKFB2 PFKL PFN1 PGK1 PHLDB2 PI4KB PIK3C2B PIK3C3 PIK3CB PKM PPFIBP1 PRDX1 PRKCQ PRKCZ PRKD1 PRKDC PRMT5 PSME3 PTPN3 RAF1 RAI14 RCOR3 REM1 RFC1 RGS3 RGS7 RNASE2 RPL10A RPL15 RPL19 RPL7 RPLP0 RPLP2 RPS3 RUVBL2 SAMSN1 SH3BP2 SLC27A2 SLC8A1 SLC8A2 SLC8A3 SMAD9 SNRPE SPR SPTA1 SPTB SRSF3 SSBP1 SSFA2 SSX2IP TCP1 TERT THRA TLN1 TNF TNFAIP3 TP53BP2 TPI1 TPR TRIM28 TRIM42 TSC1 TSC2 TUBA1A TUBA3C TUBB UBQLN4 UCP2 UCP3 ULK4 USP8 VARS WDR61 WDR77 WEE1 WTAP WWC2 WWP1 YAP1 YWHAE YWHAG ZC3H13 ZHX2	31 interactors: APBB1 C14orf1 C1orf123 CCT7 COPS6 CSAD DYSF EGFR FAF1 FPR1 GAPDH HMGA1 KLHL23 KMT2B KRT8 LRIF1 MEIS2 OTUB1 PRKCI RPA1 S100A11 SRC TGM2 TRPM7 UBE2D1 UBE2I UBE3A UCHL5 UNC119 XRCC6 YWHAQ
Entrez ID		10971	301
HPRD ID		00886	01060
Ensembl ID		ENSG00000134308	ENSG00000135046
Uniprot IDs		B4DMT8 P27348	P04083 Q5TZZ9
PDB IDs		2BTP	1AIN 1BO9 1QLS
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Cellular Metabolic Process Organelle Organization Cellular Process Cellular Response To Organic Substance Regulation Of Cellular Component Organization Response To Organic Substance Response To Stimulus Positive Regulation Of Cellular Metabolic Process Developmental Process Positive Regulation Of Metabolic Process Regulation Of Cell Death Mitotic Cell Cycle Regulation Of Metabolic Process Response To Stress Cell Cycle Cellular Response To Stimulus Mitotic Cell Cycle Process Death Regulation Of Apoptotic Process Programmed Cell Death Regulation Of Protein Localization Intracellular Signal Transduction Apoptotic Process Cell Cycle Process Anatomical Structure Development Cell Death Regulation Of Cellular Localization System Development Multicellular Organismal Development Regulation Of Establishment Of Protein Localization Negative Regulation Of Cellular Metabolic Process Regulation Of Cellular Process Regulation Of Cell Cycle Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Abiotic Stimulus Positive Regulation Of Protein Metabolic Process Intracellular Transport Regulation Of Signaling Nucleobase-containing Compound Metabolic Process Cellular Response To Stress Regulation Of Phosphorylation Innate Immune Response MRNA Metabolic Process Cellular Localization Immune System Process Regulation Of Kinase Activity	Negative Regulation Of Biosynthetic Process Viral Process Response To Abiotic Stimulus Regulation Of Protein Metabolic Process Cellular Protein Modification Process Regulation Of Cellular Protein Metabolic Process Cellular Protein Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Regulation Of Caveolin-mediated Endocytosis Establishment Of Integrated Proviral Latency Positive Regulation Of Transferase Activity Establishment Of Viral Latency Cellular Macromolecule Catabolic Process Regulation Of Metabolic Process Regulation Of DNA Repair Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death DNA Repair Response To Growth Factor Negative Regulation Of Protein Metabolic Process Positive Regulation Of Cell Death Regulation Of Protein Catabolic Process Positive Regulation Of Signal Transduction Peptidyl-amino Acid Modification Organ Development Magnesium Ion Homeostasis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Cellular Response To Stimulus Programmed Cell Death Organelle Organization Catabolic Process Cell Death Death Positive Regulation Of Gene Expression, Epigenetic Regulation Of Transcription, DNA-templated Response To Stimulus Regulation Of Gene Expression Peptidyl-lysine Modification Protein Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Brain Development Reproductive Structure Development Ubiquitin-dependent Protein Catabolic Process Reproductive System Development Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Tagcloud ?			aldh1a1 bcar1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1
Tagcloud (Difference) ?			aldh1a1 bcar1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1
Tagcloud (Intersection) ?