YWHAQ and PRKD1

Number of citations of the paper that reports this interaction (PubMedID 31980649)
68

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vitro, in vivo)

		YWHAQ	PRKD1
Description		tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta	protein kinase D1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Focal Adhesion Membrane Protein-containing Complex Synapse Extracellular Exosome	Autophagosome Membrane Nucleus Cytoplasm Golgi Apparatus Trans-Golgi Network Cytosol Plasma Membrane Cell-cell Junction Cell Cortex Membrane Z Disc Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Protein Domain Specific Binding Identical Protein Binding Transmembrane Transporter Binding 14-3-3 Protein Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Protein Kinase C Binding Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Heat Shock Protein Binding Identical Protein Binding Metal Ion Binding Protein Serine Kinase Activity Phosphatidylinositol 3-kinase Activator Activity
	Biological Process	Protein Targeting Signal Transduction Small GTPase-mediated Signal Transduction Intracellular Protein Localization Substantia Nigra Development Negative Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of DNA-templated Transcription	Angiogenesis Positive Regulation Of Endothelial Cell Proliferation Immune System Process Apoptotic Process Inflammatory Response Golgi Organization Signal Transduction Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Integrin-mediated Signaling Pathway Nervous System Development Positive Regulation Of Autophagy Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Regulation Of Keratinocyte Proliferation Positive Regulation Of Neuron Projection Development Regulation Of Skeletal Muscle Contraction By Modulation Of Calcium Ion Sensitivity Of Myofibril Sphingolipid Biosynthetic Process Cell Differentiation Cellular Response To Amino Acid Starvation Cellular Response To Oxidative Stress Intracellular Signal Transduction Cellular Response To Vascular Endothelial Growth Factor Stimulus Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Blood Vessel Endothelial Cell Migration Cell-cell Adhesion Mediated By Cadherin Innate Immune Response Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Cell Size Negative Regulation Of Endocytosis Positive Regulation Of Transcription By RNA Polymerase II Protein Autophosphorylation Positive Regulation Of Protein Export From Nucleus Vascular Endothelial Growth Factor Receptor Signaling Pathway Golgi Vesicle Transport Defense Response To Gram-negative Bacterium Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Sarcomere Organization Transepithelial Transport Cellular Response To Hydroperoxide Response To Norepinephrine Cellular Response To Norepinephrine Stimulus Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of NLRP3 Inflammasome Complex Assembly Cellular Response To Angiotensin Cellular Response To Phorbol 13-acetate 12-myristate Cellular Response To Endothelin Positive Regulation Of Endothelial Cell Chemotaxis Regulation Of Integrin-mediated Signaling Pathway
Pathways		Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane RHO GTPases activate PKNs TP53 Regulates Metabolic Genes Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Regulation of localization of FOXO transcription factors SARS-CoV-1 targets host intracellular signalling and regulatory pathways SARS-CoV-2 targets host intracellular signalling and regulatory pathways	Sphingolipid de novo biosynthesis
Drugs		Phenethyl Isothiocyanate	Bryostatin 1 Fostamatinib
Diseases
GWAS		Heart rate variability traits ( 22174390) Non-response to selective serotonin reuptake inhibitors and depression ( 27622933)	Academic attainment (English) ( 33594131) Adult body size ( 32376654) BMI (adjusted for smoking behaviour) ( 28443625) Body mass index ( 20935630 23669352 25673413 28552196 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) Body size at age 10 ( 32376654) California verbal learning test score ( 31596458) Carotid plaque burden ( 28282560) Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872) Childhood body mass index ( 26604143) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Daytime nap ( 33568662) General cognitive ability ( 29844566) General risk tolerance (MTAG) ( 30643258) Hip circumference ( 28552196) Household income (MTAG) ( 31844048) IgM levels ( 28628107) Intelligence (MTAG) ( 29326435) Neurociticism ( 29500382) Obesity-related traits ( 23251661) Schizophrenia ( 30285260 29483656 25056061 34099189) Spatial processing ( 31596458) Systolic blood pressure ( 30224653) Type 2 diabetes ( 30130595) Urinary sodium excretion ( 31409800) Waist circumference ( 28552196 25673412) Weight ( 28552196)
Interacting Genes		216 interacting genes: AARS2 ABL1 ACSL4 ADRB2 AGTR1 AHCY AKT1S1 ANXA1 ANXA2 AR ARHGAP10 ARHGEF16 ATP5F1A BAD BAX BCAP31 BCR BRAF CABIN1 CAPN3 CBL CBLL1 CCDC125 CDC25A CDC25B CDC25C CDC5L CDK11B CDK14 CDK16 CDKN1A CDKN1B CFL1 CHAF1A CKM CLTC COPS4 CSE1L CSNK1A1 CSNK2A1 CTPS1 DAB2IP DCPS DDX1 DDX3X DHX9 DISC1 DNMT1 DYNC1H1 E2F1 EFNB1 EGFR EIF4A3 ENO1 EPB41 EPB41L1 EPB41L3 ESR1 ESR2 FASN FBLN1 FGR FSCN1 FSHR FXYD1 GAPDH GCN1 H2BC8 H4C14 HADHA HAT1 HAX1 HDAC7 HNRNPC HNRNPH1 HSPA1A HSPA8 HSPB1 HUS1 IARS2 ING1 ITCH ITGB4 KANK1 KCNK15 KCNK3 KCNK9 KIF5B KLC2 KLC3 KRT1 KRT9 LARP1 LARS2 LDHA LIMA1 LMNA LMNB1 LYST MAGOH MAP3K3 MAP3K5 MCM3 MDM4 MED1 MEF2D MPL MPRIP MRPS27 MST1R MTNR1B MTOR MYCBP2 NADK NCL NCOA1 NCOA3 NDE1 NEDD4L NFATC1 NFATC2 NFATC4 NFKB1 NIF3L1 NME7 NOLC1 NUMA1 PABPN1 PANK1 PDCD6 PDE3A PDE3B PDE4B PDK1 PDPK1 PDXK PFKFB2 PFKL PFN1 PGK1 PHLDB2 PI4KB PIK3C3 PIK3CB PKM PRDX1 PRKCQ PRKCZ PRKD1 PRKDC PRMT5 PSME3 RAI14 RCOR3 REM1 RFC1 RGS3 RGS7 RIPK2 RNASE2 RPL10A RPL15 RPL19 RPL7 RPLP0 RPLP2 RPS3 RUVBL2 SAMSN1 SH3BP2 SKIC8 SLC27A2 SLC8A1 SLC8A2 SLC8A3 SMAD9 SNRPE SOCS3 SPR SPTA1 SPTB SRSF3 SSBP1 SSX2IP SUMO2 TCP1 TERT THRA TLN1 TNF TNFAIP3 TPI1 TPR TRAF6 TRIM25 TRIM28 TRIM42 TSC1 TSC2 TUBA1A TUBA3C TUBB UBQLN4 UCP2 UCP3 ULK4 USP8 VARS1 WDR77 WTAP WWC2 WWP1 YAP1 YWHAG ZC3H13 ZHX2	33 interacting genes: ABL1 ADAP1 AKAP13 BTK C1QBP COPS2 COPS5 COPS7A EGFR EPAS1 HDAC5 HDAC7 IBTK IGF1R JUN KIDINS220 MAPK8 MAPK9 MT2A NOS1 PLCG1 PLCG2 PPP1R14A PRKCE PRKCH RACK1 SPRY2 SRC SYK TFAP2A TP53 USP28 YWHAQ
Entrez ID		10971	5587
HPRD ID		00886	05668
Ensembl ID		ENSG00000134308	ENSG00000184304
Uniprot IDs		P27348	F8WBA3 Q15139
PDB IDs		2BTP 5IQP 6BCR 6BD2 6BQT 6KZG 6KZH
Enriched GO Terms of Interacting Partners?		Cytosol Cytoplasm Regulation Of Signaling Regulation Of Cell Communication Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Multicellular Organismal Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Protein Metabolic Process ATP Binding Regulation Of Cellular Component Organization Regulation Of Primary Metabolic Process Negative Regulation Of Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Regulation Of Programmed Cell Death Positive Regulation Of Metabolic Process Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of Metabolic Process Nucleus Cadherin Binding Kinase Activity Negative Regulation Of Programmed Cell Death Regulation Of Developmental Process Nucleobase-containing Compound Metabolic Process Cellular Response To Stress Nucleotide Binding Regulation Of Biological Quality Regulation Of Macromolecule Metabolic Process Positive Regulation Of Protein Metabolic Process Cell Cortex Cellular Response To Oxygen-containing Compound Response To Stress Protein-containing Complex Glucose Catabolic Process Organelle Organization Positive Regulation Of Multicellular Organismal Process Macromolecule Metabolic Process ADP Metabolic Process RNA Binding Cellular Response To Lipid Positive Regulation Of Cell Communication Positive Regulation Of Signaling Extracellular Exosome Regulation Of Organelle Organization Positive Regulation Of Cell Population Proliferation Glycolytic Process Cellular Response To Hormone Stimulus	Intracellular Signaling Cassette Fc Receptor Signaling Pathway Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Regulation Of Programmed Cell Death Positive Regulation Of Protein-containing Complex Assembly Cytosol Positive Regulation Of Cell Migration Regulation Of Apoptotic Process Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Protein Metabolic Process Regulation Of Protein Modification Process Phosphorylation Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Enzyme Binding Signal Transduction Regulation Of Protein-containing Complex Assembly Negative Regulation Of Metabolic Process Negative Regulation Of Programmed Cell Death MAPK Cascade Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein-containing Complex Negative Regulation Of Macromolecule Metabolic Process Protein Phosphorylation Regulation Of Post-translational Protein Modification Positive Regulation Of Intracellular Signal Transduction Kinase Activity Protein Kinase C Binding Response To Lipid Regulation Of Cell Migration Regulation Of Multicellular Organismal Process Positive Regulation Of Epithelial Cell Migration Protein Kinase Activity Cell Activation Regulation Of Protein Neddylation Positive Regulation Of Cellular Component Biogenesis Regulation Of Cell Motility Cellular Response To Growth Factor Stimulus Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Cellular Response To Oxygen-containing Compound Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Immune Response-regulating Signaling Pathway Regulation Of Locomotion Positive Regulation Of Programmed Cell Death
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