YWHAQ and EPB41L3

Number of citations of the paper that reports this interaction (PubMedID 16368544)
0

Data Source:
HPRD (two hybrid)

		YWHAQ	EPB41L3
Description		tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta	erythrocyte membrane protein band 4.1 like 3
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Focal Adhesion Membrane Protein-containing Complex Synapse Extracellular Exosome	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell-cell Junction Cilium Membrane Cell Junction Axolemma Paranode Region Of Axon Ciliary Basal Body Juxtaparanode Region Of Axon Anchoring Junction Postsynapse Glutamatergic Synapse
	Molecular Function	Protein Binding Protein Domain Specific Binding Identical Protein Binding Transmembrane Transporter Binding 14-3-3 Protein Binding	Actin Binding Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Protein Binding Cytoskeletal Protein-membrane Anchor Activity
	Biological Process	Protein Targeting Signal Transduction Small GTPase-mediated Signal Transduction Intracellular Protein Localization Substantia Nigra Development Negative Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of DNA-templated Transcription	Protein Localization To Paranode Region Of Axon Apoptotic Process Biological_process Regulation Of Cell Shape Cortical Cytoskeleton Organization Cortical Actin Cytoskeleton Organization Paranodal Junction Assembly Actomyosin Structure Organization Myelin Maintenance Neuron Projection Morphogenesis Protein Localization To Juxtaparanode Region Of Axon Protein Localization To Plasma Membrane Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane
Pathways		Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane RHO GTPases activate PKNs TP53 Regulates Metabolic Genes Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Regulation of localization of FOXO transcription factors SARS-CoV-1 targets host intracellular signalling and regulatory pathways SARS-CoV-2 targets host intracellular signalling and regulatory pathways	Neurexins and neuroligins Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea
Drugs		Phenethyl Isothiocyanate
Diseases
GWAS		Heart rate variability traits ( 22174390) Non-response to selective serotonin reuptake inhibitors and depression ( 27622933)	Cerebral amyloid deposition (PET imaging) ( 26252872) Chronic kidney disease ( 31152163) Diverticular disease ( 30177863) Estimated glomerular filtration rate ( 30604766 31015462 31152163 31451708) Glomerular filtration rate (creatinine) ( 28452372) Lacunar stroke ( 33773637) Optic nerve head parameters (multi-trait analysis) ( 31798171) Sleep duration ( 25469926) Social communication problems ( 24564958) Thyroid nodules ( 30099483) Vertical cup-disc ratio ( 31798171)
Interacting Genes		216 interacting genes: AARS2 ABL1 ACSL4 ADRB2 AGTR1 AHCY AKT1S1 ANXA1 ANXA2 AR ARHGAP10 ARHGEF16 ATP5F1A BAD BAX BCAP31 BCR BRAF CABIN1 CAPN3 CBL CBLL1 CCDC125 CDC25A CDC25B CDC25C CDC5L CDK11B CDK14 CDK16 CDKN1A CDKN1B CFL1 CHAF1A CKM CLTC COPS4 CSE1L CSNK1A1 CSNK2A1 CTPS1 DAB2IP DCPS DDX1 DDX3X DHX9 DISC1 DNMT1 DYNC1H1 E2F1 EFNB1 EGFR EIF4A3 ENO1 EPB41 EPB41L1 EPB41L3 ESR1 ESR2 FASN FBLN1 FGR FSCN1 FSHR FXYD1 GAPDH GCN1 H2BC8 H4C14 HADHA HAT1 HAX1 HDAC7 HNRNPC HNRNPH1 HSPA1A HSPA8 HSPB1 HUS1 IARS2 ING1 ITCH ITGB4 KANK1 KCNK15 KCNK3 KCNK9 KIF5B KLC2 KLC3 KRT1 KRT9 LARP1 LARS2 LDHA LIMA1 LMNA LMNB1 LYST MAGOH MAP3K3 MAP3K5 MCM3 MDM4 MED1 MEF2D MPL MPRIP MRPS27 MST1R MTNR1B MTOR MYCBP2 NADK NCL NCOA1 NCOA3 NDE1 NEDD4L NFATC1 NFATC2 NFATC4 NFKB1 NIF3L1 NME7 NOLC1 NUMA1 PABPN1 PANK1 PDCD6 PDE3A PDE3B PDE4B PDK1 PDPK1 PDXK PFKFB2 PFKL PFN1 PGK1 PHLDB2 PI4KB PIK3C3 PIK3CB PKM PRDX1 PRKCQ PRKCZ PRKD1 PRKDC PRMT5 PSME3 RAI14 RCOR3 REM1 RFC1 RGS3 RGS7 RIPK2 RNASE2 RPL10A RPL15 RPL19 RPL7 RPLP0 RPLP2 RPS3 RUVBL2 SAMSN1 SH3BP2 SKIC8 SLC27A2 SLC8A1 SLC8A2 SLC8A3 SMAD9 SNRPE SOCS3 SPR SPTA1 SPTB SRSF3 SSBP1 SSX2IP SUMO2 TCP1 TERT THRA TLN1 TNF TNFAIP3 TPI1 TPR TRAF6 TRIM25 TRIM28 TRIM42 TSC1 TSC2 TUBA1A TUBA3C TUBB UBQLN4 UCP2 UCP3 ULK4 USP8 VARS1 WDR77 WTAP WWC2 WWP1 YAP1 YWHAG ZC3H13 ZHX2	20 interacting genes: ATXN1L CADM1 CEP152 CLNS1A CNTNAP2 HSPB1 IGSF21 MBIP MECOM PAXIP1 PSEN1 SPANXN2 SPTBN1 TCF4 UNC13A YWHAB YWHAG YWHAH YWHAQ YWHAZ
Entrez ID		10971	23136
HPRD ID		00886	05622
Ensembl ID		ENSG00000134308	ENSG00000082397
Uniprot IDs		P27348	A0A0A0MRA8 A8K968 Q9Y2J2
PDB IDs		2BTP 5IQP 6BCR 6BD2 6BQT 6KZG 6KZH	2HE7 3BIN 5RYM 5RYN 5RYO 5RYP 5RYQ 5RYR 5RYS 5RYT 5RYU 5RYV 5RYW 5RYX 5RYY 5RYZ 5RZ0 5RZ1 5RZ2 5RZ3 5RZ4 5RZ5 5RZ6 5RZ7 5RZ8 5RZ9 5RZA 5RZB 5RZC 5RZD 5RZE 5RZF 5RZG 5RZH 5RZI 5RZJ 5RZK 5RZL 5RZM 5RZN 5RZO 5RZP 5RZQ 5RZR 5RZS 5RZT 5RZU 5RZV 5RZW 5RZX 5RZY 5RZZ 5S00 6IBE
Enriched GO Terms of Interacting Partners?		Cytosol Cytoplasm Regulation Of Signaling Regulation Of Cell Communication Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Multicellular Organismal Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Protein Metabolic Process ATP Binding Regulation Of Cellular Component Organization Regulation Of Primary Metabolic Process Negative Regulation Of Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Regulation Of Programmed Cell Death Positive Regulation Of Metabolic Process Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of Metabolic Process Nucleus Cadherin Binding Kinase Activity Negative Regulation Of Programmed Cell Death Regulation Of Developmental Process Nucleobase-containing Compound Metabolic Process Cellular Response To Stress Nucleotide Binding Regulation Of Biological Quality Regulation Of Macromolecule Metabolic Process Positive Regulation Of Protein Metabolic Process Cell Cortex Cellular Response To Oxygen-containing Compound Response To Stress Protein-containing Complex Glucose Catabolic Process Organelle Organization Positive Regulation Of Multicellular Organismal Process Macromolecule Metabolic Process ADP Metabolic Process RNA Binding Cellular Response To Lipid Positive Regulation Of Cell Communication Positive Regulation Of Signaling Extracellular Exosome Regulation Of Organelle Organization Positive Regulation Of Cell Population Proliferation Glycolytic Process Cellular Response To Hormone Stimulus	Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Protein Kinase C Inhibitor Activity Protein Domain Specific Binding Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Presynaptic Membrane Phosphoserine Residue Binding Protein Sequestering Activity Transmembrane Transporter Binding Regulation Of Macromolecule Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Metabolic Process Establishment Of Protein Localization Synapse Protein Targeting Axolemma Intracellular Protein Localization Regulation Of Metabolic Process Focal Adhesion Insulin-like Growth Factor Receptor Binding Positive Regulation Of Metabolic Process Modulation Of Chemical Synaptic Transmission Regulation Of Primary Metabolic Process Cell Recognition Glutamatergic Synapse Cadherin Binding Positive Regulation Of Lymphocyte Mediated Immunity Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Identical Protein Binding Negative Regulation Of Biosynthetic Process Regulation Of Protein Localization To Nucleus Regulation Of RNA Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Protein Kinase C Signaling Negative Regulation Of Core Promoter Binding Transferase Activity, Transferring One-carbon Groups Thymidylate Synthase Activity Glucocorticoid Catabolic Process Regulation Of Developmental Process Protein Kinase Inhibitor Activity Substantia Nigra Development Neuron Recognition Protein Kinase C Binding Regulation Of Neuron Differentiation Negative Regulation Of Protein Localization To Nucleus
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