YWHAQ and PRDX1

Number of citations of the paper that reports this interaction (PubMedID 15161933)
0

Data Source:
BioGRID (pull down)

		YWHAQ	PRDX1
Description		tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta	peroxiredoxin 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Focal Adhesion Membrane Protein-containing Complex Synapse Extracellular Exosome	Extracellular Space Nucleus Cytoplasm Cytosol Melanosome Extracellular Exosome
	Molecular Function	Protein Binding Protein Domain Specific Binding Identical Protein Binding Transmembrane Transporter Binding 14-3-3 Protein Binding	RNA Binding Peroxidase Activity Protein Binding Thioredoxin Peroxidase Activity Antioxidant Activity Oxidoreductase Activity Identical Protein Binding Cadherin Binding Peroxiredoxin Activity Thioredoxin-dependent Peroxiredoxin Activity
	Biological Process	Protein Targeting Signal Transduction Small GTPase-mediated Signal Transduction Intracellular Protein Localization Substantia Nigra Development Negative Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of DNA-templated Transcription	Response To Reactive Oxygen Species Skeletal System Development Response To Oxidative Stress Canonical NF-kappaB Signal Transduction Cell Population Proliferation Removal Of Superoxide Radicals Natural Killer Cell Activation Regulation Of Stress-activated MAPK Cascade Erythrocyte Homeostasis Natural Killer Cell Mediated Cytotoxicity Hydrogen Peroxide Catabolic Process Leukocyte Activation Cell Redox Homeostasis Fibroblast Proliferation Regulation Of Non-canonical NF-kappaB Signal Transduction
Pathways		Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane RHO GTPases activate PKNs TP53 Regulates Metabolic Genes Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Regulation of localization of FOXO transcription factors SARS-CoV-1 targets host intracellular signalling and regulatory pathways SARS-CoV-2 targets host intracellular signalling and regulatory pathways	Detoxification of Reactive Oxygen Species TP53 Regulates Metabolic Genes Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models NFE2L2 regulating anti-oxidant/detoxification enzymes
Drugs		Phenethyl Isothiocyanate	Zinc Copper Artenimol Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Heart rate variability traits ( 22174390) Non-response to selective serotonin reuptake inhibitors and depression ( 27622933)	Body mass index ( 26426971) Hemoglobin ( 32888494)
Interacting Genes		216 interacting genes: AARS2 ABL1 ACSL4 ADRB2 AGTR1 AHCY AKT1S1 ANXA1 ANXA2 AR ARHGAP10 ARHGEF16 ATP5F1A BAD BAX BCAP31 BCR BRAF CABIN1 CAPN3 CBL CBLL1 CCDC125 CDC25A CDC25B CDC25C CDC5L CDK11B CDK14 CDK16 CDKN1A CDKN1B CFL1 CHAF1A CKM CLTC COPS4 CSE1L CSNK1A1 CSNK2A1 CTPS1 DAB2IP DCPS DDX1 DDX3X DHX9 DISC1 DNMT1 DYNC1H1 E2F1 EFNB1 EGFR EIF4A3 ENO1 EPB41 EPB41L1 EPB41L3 ESR1 ESR2 FASN FBLN1 FGR FSCN1 FSHR FXYD1 GAPDH GCN1 H2BC8 H4C14 HADHA HAT1 HAX1 HDAC7 HNRNPC HNRNPH1 HSPA1A HSPA8 HSPB1 HUS1 IARS2 ING1 ITCH ITGB4 KANK1 KCNK15 KCNK3 KCNK9 KIF5B KLC2 KLC3 KRT1 KRT9 LARP1 LARS2 LDHA LIMA1 LMNA LMNB1 LYST MAGOH MAP3K3 MAP3K5 MCM3 MDM4 MED1 MEF2D MPL MPRIP MRPS27 MST1R MTNR1B MTOR MYCBP2 NADK NCL NCOA1 NCOA3 NDE1 NEDD4L NFATC1 NFATC2 NFATC4 NFKB1 NIF3L1 NME7 NOLC1 NUMA1 PABPN1 PANK1 PDCD6 PDE3A PDE3B PDE4B PDK1 PDPK1 PDXK PFKFB2 PFKL PFN1 PGK1 PHLDB2 PI4KB PIK3C3 PIK3CB PKM PRDX1 PRKCQ PRKCZ PRKD1 PRKDC PRMT5 PSME3 RAI14 RCOR3 REM1 RFC1 RGS3 RGS7 RIPK2 RNASE2 RPL10A RPL15 RPL19 RPL7 RPLP0 RPLP2 RPS3 RUVBL2 SAMSN1 SH3BP2 SKIC8 SLC27A2 SLC8A1 SLC8A2 SLC8A3 SMAD9 SNRPE SOCS3 SPR SPTA1 SPTB SRSF3 SSBP1 SSX2IP SUMO2 TCP1 TERT THRA TLN1 TNF TNFAIP3 TPI1 TPR TRAF6 TRIM25 TRIM28 TRIM42 TSC1 TSC2 TUBA1A TUBA3C TUBB UBQLN4 UCP2 UCP3 ULK4 USP8 VARS1 WDR77 WTAP WWC2 WWP1 YAP1 YWHAG ZC3H13 ZHX2	31 interacting genes: ABL1 ADH5 ADRB2 AXIN2 CALM1 CCR4 CDK1 CEBPA CLEC4G EGFR GAPDH IRAK1 IRF3 LUC7L MTRNR2L1 MYC MYD88 PPP2R1A PPP2R1B PRDX4 PTEN PTGER4 SESN1 SESN2 SH2D1B SMARCD1 SNCA TERF1 UBE3A VHL YWHAQ
Entrez ID		10971	5052
HPRD ID		00886	01458
Ensembl ID		ENSG00000134308	ENSG00000117450
Uniprot IDs		P27348	A0A384NPQ2 Q06830
PDB IDs		2BTP 5IQP 6BCR 6BD2 6BQT 6KZG 6KZH	2RII 3HY2 4XCS 7LJ1 7WET 7WEU 8X71 8X73 8Z54 8Z55 8Z56 8Z57 8Z58 9B7A
Enriched GO Terms of Interacting Partners?		Cytosol Cytoplasm Regulation Of Signaling Regulation Of Cell Communication Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Multicellular Organismal Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Protein Metabolic Process ATP Binding Regulation Of Cellular Component Organization Regulation Of Primary Metabolic Process Negative Regulation Of Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Regulation Of Programmed Cell Death Positive Regulation Of Metabolic Process Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of Metabolic Process Nucleus Cadherin Binding Kinase Activity Negative Regulation Of Programmed Cell Death Regulation Of Developmental Process Nucleobase-containing Compound Metabolic Process Cellular Response To Stress Nucleotide Binding Regulation Of Biological Quality Regulation Of Macromolecule Metabolic Process Positive Regulation Of Protein Metabolic Process Cell Cortex Cellular Response To Oxygen-containing Compound Response To Stress Protein-containing Complex Glucose Catabolic Process Organelle Organization Positive Regulation Of Multicellular Organismal Process Macromolecule Metabolic Process ADP Metabolic Process RNA Binding Cellular Response To Lipid Positive Regulation Of Cell Communication Positive Regulation Of Signaling Extracellular Exosome Regulation Of Organelle Organization Positive Regulation Of Cell Population Proliferation Glycolytic Process Cellular Response To Hormone Stimulus	Response To Lipid Regulation Of Multicellular Organismal Process Intracellular Signal Transduction Intracellular Signaling Cassette Cellular Response To Oxygen-containing Compound Positive Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Identical Protein Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling MAPK Cascade Positive Regulation Of Macromolecule Metabolic Process Response To Stress Positive Regulation Of Signal Transduction Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Signal Transduction Protein-containing Complex Regulation Of Intracellular Signal Transduction Positive Regulation Of Gene Expression Regulation Of Signal Transduction Molecular Adaptor Activity Negative Regulation Of Signaling Negative Regulation Of Cell Communication Cellular Response To Lipid Negative Regulation Of Metabolic Process Regulation Of Cell Cycle Regulation Of DNA Metabolic Process Chromosome Organization Nucleus ERK1 And ERK2 Cascade Regulation Of Cell Population Proliferation Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Multicellular Organismal Process Regulation Of Autophagy Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle Process Response To Cytokine Leukocyte Activation Response To Peptide Negative Regulation Of TORC1 Signaling Enzyme Binding Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Intracellular Signal Transduction Leukocyte Activation Involved In Immune Response Regulation Of Macromolecule Biosynthetic Process Regulation Of Growth Cell Activation Involved In Immune Response Positive Regulation Of DNA Metabolic Process
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