TLN1 and AZIN2

Number of citations of the paper that reports this interaction (PubMedID 30545799)
47

Data Source:
BioGRID (unspecified method)

		TLN1	AZIN2
Description		talin 1	antizyme inhibitor 2
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Extracellular Region Cytoplasm Cytosol Cytoskeleton Plasma Membrane Adherens Junction Focal Adhesion Cell Surface Membrane Ruffle Membrane Cell Projection Extracellular Exosome Anchoring Junction	Nucleus Cytoplasm Mitochondrion Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Cis-Golgi Network Trans-Golgi Network Cytosol Membrane Transport Vesicle Axon Dendrite Cytoplasmic Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Cell Projection Perikaryon Perinuclear Region Of Cytoplasm Granular Vesicle
	Molecular Function	Phosphatidylserine Binding Actin Binding Integrin Binding Structural Constituent Of Cytoskeleton Protein Binding Vinculin Binding LIM Domain Binding Phosphatidylinositol Binding Cadherin Binding Actin Filament Binding	Catalytic Activity Ornithine Decarboxylase Activity Protein Binding Arginine Decarboxylase Activity Carboxy-lyase Activity Ornithine Decarboxylase Activator Activity
	Biological Process	Cell-cell Junction Assembly Cell-substrate Junction Assembly Cell Adhesion Integrin-mediated Signaling Pathway Actin Cytoskeleton Organization Cortical Actin Cytoskeleton Organization Integrin Activation Cortical Microtubule Organization Regulation Of Focal Adhesion Assembly Platelet Aggregation Cell-cell Adhesion	Ornithine Metabolic Process Polyamine Biosynthetic Process Spermatogenesis Putrescine Biosynthetic Process From Arginine, Via Ornithine Negative Regulation Of Protein Catabolic Process Positive Regulation Of Catalytic Activity Agmatine Biosynthetic Process Trans-Golgi Network Membrane Organization Positive Regulation Of Polyamine Transmembrane Transport
Pathways		Platelet degranulation Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins XBP1(S) activates chaperone genes SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion Smooth Muscle Contraction MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	Agmatine biosynthesis
Drugs			Pyridoxal phosphate Arginine Benzoyl peroxide
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) IgE levels in asthmatics ( 23967269) Lymphocyte count ( 32888494) Monocyte count ( 32888494) Platelet distribution width ( 27863252 32888494) Plateletcrit ( 32888494)	Pursuit maintenance gain ( 29064472)
Interacting Genes		37 interacting genes: ABI1 ACTA1 ARHGAP31 AZIN2 CDK5 CEBPA DAG1 DOK1 EGFR ERBB2 FMO1 HSP90AA1 ITGA1 ITGA2B ITGB1 ITGB2 ITGB3 ITGB5 ITGB7 LRP2 MTNR1A MTNR1B NRAP NYAP1 PIP5K1C PKD1 PTK2 PTK2B PXN RET SMURF1 SUMO2 TES TPTE TUBA1A VCL YWHAQ	3 interacting genes: OAZ3 PSMC5 TLN1
Entrez ID		7094	113451
HPRD ID		01726	17657
Ensembl ID		ENSG00000137076	ENSG00000142920
Uniprot IDs		Q9Y490	Q96A70
PDB IDs		1SYQ 2MWN 4DJ9 6R9T
Enriched GO Terms of Interacting Partners?		Focal Adhesion Cell-matrix Adhesion Cell-substrate Adhesion Integrin Complex Integrin-mediated Signaling Pathway Cell Migration Receptor Complex Cell Motility Cell Adhesion Cell-cell Adhesion Cell Surface Receptor Signaling Pathway Signal Transduction Cell Adhesion Mediated By Integrin Lamellipodium Enzyme-linked Receptor Protein Signaling Pathway Filopodium Virus Receptor Activity Regulation Of Protein Metabolic Process Cell Surface Anchoring Junction Cell Projection Symbiont Entry Into Host Cell Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Plasma Membrane Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Extracellular Exosome Signal Complex Assembly Developmental Process Integrin Binding Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of Protein Metabolic Process Heterotypic Cell-cell Adhesion Biological Process Involved In Interaction With Host Neuron Projection Morphogenesis Protein Phosphatase Binding Vinculin Binding Cell Projection Morphogenesis Cell Projection Organization Ruffle Membrane Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Wound Healing, Spreading Of Epidermal Cells Integrin Alpha1-beta1 Complex Regulation Of Cell Migration Positive Regulation Of Fibroblast Migration Regulation Of Apoptotic Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell Adhesion Anatomical Structure Morphogenesis Regulation Of Cell-matrix Adhesion Regulation Of Cell Development	Nuclear Proteasome Complex Blood Microparticle Thyrotropin-releasing Hormone Receptor Binding Positive Regulation Of Protein Catabolic Process Ornithine Decarboxylase Inhibitor Activity Negative Regulation Of Polyamine Transmembrane Transport Proteasome-activating Activity Cytosolic Proteasome Complex Positive Regulation Of Inclusion Body Assembly LIM Domain Binding Ankyrin Repeat Binding Viral Translational Frameshifting Regulation Of Protein Catabolic Process Cortical Microtubule Organization Proteasome Regulatory Particle, Base Subcomplex General Transcription Initiation Factor Binding Proteasome Regulatory Particle Vinculin Binding Integrin Activation Polyamine Biosynthetic Process Regulation Of Cellular Component Organization Proteasome Accessory Complex Positive Regulation Of Catabolic Process Polyamine Metabolic Process Inclusion Body Transcription Factor Binding Regulation Of Inclusion Body Assembly TBP-class Protein Binding Cortical Actin Cytoskeleton Organization Negative Regulation Of Stress Fiber Assembly Positive Regulation Of Protein Metabolic Process Amine Biosynthetic Process Negative Regulation Of Actin Filament Bundle Assembly Biogenic Amine Biosynthetic Process Cell-substrate Junction Assembly Cell-substrate Junction Organization Cortical Cytoskeleton Organization Platelet Aggregation
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?