YWHAQ and BRAF

Number of citations of the paper that reports this interaction (PMID 17353931)
246

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology)
HPRD (two hybrid)

		YWHAQ	BRAF
Gene Name		tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta	B-Raf proto-oncogene, serine/threonine kinase
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Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Focal Adhesion Membrane Cytoplasmic Vesicle Membrane Extracellular Vesicular Exosome	Nucleus Mitochondrion Cytosol Plasma Membrane Neuron Projection Cell Body
	Molecular Function	Protein Binding Protein Domain Specific Binding Protein N-terminus Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Calcium Ion Binding Protein Binding ATP Binding Small GTPase Binding Mitogen-activated Protein Kinase Kinase Binding Identical Protein Binding Protein Heterodimerization Activity
	Biological Process	Protein Targeting Apoptotic Process Small GTPase Mediated Signal Transduction Substantia Nigra Development Negative Regulation Of Transcription, DNA-templated Membrane Organization Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway	MAPK Cascade Activation Of MAPKK Activity Myeloid Progenitor Cell Differentiation Protein Phosphorylation Small GTPase Mediated Signal Transduction Synaptic Transmission Visual Learning Fibroblast Growth Factor Receptor Signaling Pathway Organ Morphogenesis Positive Regulation Of Gene Expression Negative Regulation Of Fibroblast Migration Positive Regulation Of Peptidyl-serine Phosphorylation Somatic Stem Cell Maintenance Cellular Response To Drug Regulation Of Cell Proliferation Negative Regulation Of Apoptotic Process CD4-positive, Alpha-beta T Cell Differentiation Positive T Cell Selection Response To Peptide Hormone Negative Regulation Of Neuron Apoptotic Process Neurotrophin TRK Receptor Signaling Pathway Protein Heterooligomerization Positive Regulation Of Stress Fiber Assembly Response To CAMP Long-term Synaptic Potentiation Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Calcium Ion Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Synaptic Vesicle Exocytosis Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways		Activation of BAD and translocation to mitochondria Programmed Cell Death Translocation of GLUT4 to the plasma membrane Activation of BH3-only proteins Intrinsic Pathway for Apoptosis	Signalling to ERKs Prolonged ERK activation events Signalling by NGF Signaling by FGFR in disease NGF signalling via TRKA from the plasma membrane Spry regulation of FGF signaling CREB phosphorylation through the activation of Ras Signaling by FGFR ARMS-mediated activation Activation of NMDA receptor upon glutamate binding and postsynaptic events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Signalling to p38 via RIT and RIN Frs2-mediated activation Transmission across Chemical Synapses Post NMDA receptor activation events Negative regulation of FGFR signaling
Drugs			Sorafenib N-{3-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl}propane-1-sulfonamide N-{2,4-difluoro-3-[(5-pyridin-3-yl-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]phenyl}ethanesulfonamide (1E)-5-(1-piperidin-4-yl-3-pyridin-4-yl-1H-pyrazol-4-yl)-2,3-dihydro-1H-inden-1-one oxime Vemurafenib Regorafenib Dabrafenib
Diseases
GWAS		Heart rate variability traits ( 22174390)	Response to Vitamin E supplementation ( 22437554)
Protein-Protein Interactions		231 interactors: AARS2 ABL1 ACSL4 AHCY AKT1S1 ANXA1 ANXA2 APC AR ARHGAP10 ARHGEF16 ATP5A1 BAD BAX BCAP31 BCR BRAF CABIN1 CAPN3 CBL CBLL1 CDC25A CDC25B CDC25C CDC5L CDK11B CDK14 CDK16 CDK17 CDK18 CDKN1A CDKN1B CEP170 CFL1 CHAF1A CKM CLTC COPS4 CSE1L CSNK1A1 CSNK2A1 CTPS1 DAB2IP DCPS DDX1 DDX3X DHX9 DISC1 DNMT1 DYNC1H1 E2F1 EFNB1 EIF4A3 ENO1 EPB41 EPB41L1 EPB41L3 ESR1 ESR2 EXO1 FASN FBLN1 FGR FSCN1 FSHR FXYD1 GAPDH GCN1L1 HADHA HAT1 HAX1 HDAC4 HDAC5 HDAC7 HIST1H2BG HIST2H4A HNRNPA1 HNRNPC HNRNPF HNRNPH1 HNRNPK HSPA1A HSPA8 HUS1 IARS2 ING1 IQGAP1 IRS2 ITGB4 KCNK15 KCNK3 KCNK9 KIAA1429 KIF1C KIF23 KIF5B KLC2 KLC3 KRT1 KRT9 LARP1 LARS2 LDHA LIMA1 LMNA LMNB1 LMO7 LYST MAGOH MAP3K3 MAP3K5 MARK2 MARK3 MCM3 MDM4 MED1 MEF2D MPL MPRIP MRPS27 MST1R MTNR1B MTOR MYCBP2 NADK NCL NCOA1 NCOA3 NDE1 NFATC1 NFATC2 NFATC4 NFKB1 NIF3L1 NME7 NOLC1 NUMA1 PABPC4 PABPN1 PAK4 PANK1 PCM1 PDCD6 PDE3A PDE3B PDK1 PDPK1 PDXK PFKFB2 PFKL PFN1 PGK1 PHLDB2 PI4KB PIK3C2B PIK3C3 PIK3CB PKM PPFIBP1 PRDX1 PRKCQ PRKCZ PRKD1 PRKDC PRMT5 PSME3 PTPN3 RAF1 RAI14 RCOR3 REM1 RFC1 RGS3 RGS7 RNASE2 RPL10A RPL15 RPL19 RPL7 RPLP0 RPLP2 RPS3 RUVBL2 SAMSN1 SH3BP2 SLC27A2 SLC8A1 SLC8A2 SLC8A3 SMAD9 SNRPE SPR SPTA1 SPTB SRSF3 SSBP1 SSFA2 SSX2IP TCP1 TERT THRA TLN1 TNF TNFAIP3 TP53BP2 TPI1 TPR TRIM28 TRIM42 TSC1 TSC2 TUBA1A TUBA3C TUBB UBQLN4 UCP2 UCP3 ULK4 USP8 VARS WDR61 WDR77 WEE1 WTAP WWC2 WWP1 YAP1 YWHAE YWHAG ZC3H13 ZHX2	25 interactors: AKT1 BAD CCDC88A HRAS MAP2K1 MAP2K2 MAPK1 MRAS NEDD4L OIP5 PAK2 PRKACA PRKCE RAF1 RAP1A RAP1GAP RHEB RPS6KB2 SGK1 TERF1 YWHAB YWHAG YWHAH YWHAQ YWHAZ
Entrez ID		10971	673
HPRD ID		00886	01264
Ensembl ID		ENSG00000134308	ENSG00000157764
Uniprot IDs		B4DMT8 P27348	P15056
PDB IDs		2BTP	1UWH 1UWJ 2FB8 2L05 3C4C 3D4Q 3IDP 3II5 3NY5 3OG7 3PPJ 3PPK 3PRF 3PRI 3PSB 3PSD 3Q4C 3Q96 3SKC 3TV4 3TV6 4DBN 4E26 4E4X 4EHE 4EHG 4FK3 4G9C 4G9R 4H58 4JVG 4KSP 4KSQ 4MBJ
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Cellular Metabolic Process Organelle Organization Cellular Process Cellular Response To Organic Substance Regulation Of Cellular Component Organization Response To Organic Substance Response To Stimulus Positive Regulation Of Cellular Metabolic Process Developmental Process Positive Regulation Of Metabolic Process Regulation Of Cell Death Mitotic Cell Cycle Regulation Of Metabolic Process Response To Stress Cell Cycle Cellular Response To Stimulus Mitotic Cell Cycle Process Death Regulation Of Apoptotic Process Programmed Cell Death Regulation Of Protein Localization Intracellular Signal Transduction Apoptotic Process Cell Cycle Process Anatomical Structure Development Cell Death Regulation Of Cellular Localization System Development Multicellular Organismal Development Regulation Of Establishment Of Protein Localization Negative Regulation Of Cellular Metabolic Process Regulation Of Cellular Process Regulation Of Cell Cycle Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Abiotic Stimulus Positive Regulation Of Protein Metabolic Process Intracellular Transport Regulation Of Signaling Nucleobase-containing Compound Metabolic Process Cellular Response To Stress Regulation Of Phosphorylation Innate Immune Response MRNA Metabolic Process Cellular Localization Immune System Process Regulation Of Kinase Activity	Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Intracellular Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Cellular Component Organization Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Fc Receptor Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Cellular Response To Organonitrogen Compound Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Kinase Activity Regulation Of Organelle Organization Immune Response-regulating Cell Surface Receptor Signaling Pathway Apoptotic Process Positive Regulation Of Transferase Activity Regulation Of Signal Transduction Programmed Cell Death Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Mitochondrion Organization Regulation Of Kinase Activity Regulation Of Cellular Localization Regulation Of Intracellular Transport Cell Death Death Response To Organonitrogen Compound Cellular Response To Peptide Hormone Stimulus Activation Of MAPKK Activity Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Kinase Activity Cellular Response To Peptide Cellular Response To Insulin Stimulus Positive Regulation Of Phosphorylation Apoptotic Signaling Pathway Regulation Of Signaling Regulation Of Protein Metabolic Process Cell Communication Insulin Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Protein Kinase Activity
Tagcloud ?			al araf augmentation craf1 die differentiated disruption dramatically drosophila elegans embryos enlarged establish failed finding gestation interacts mek membranes mid mutagenesis programmed ras signalling unlike unpublished vessels w
Tagcloud (Difference) ?			al araf augmentation craf1 die differentiated disruption dramatically drosophila elegans embryos enlarged establish failed finding gestation interacts mek membranes mid mutagenesis programmed ras signalling unlike unpublished vessels w
Tagcloud (Intersection) ?