TLN1

Gene Name		talin 1
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Gene Ontology Annotations	Cellular Component	Ruffle Extracellular Region Cytoplasm Microtubule Organizing Center Cytosol Plasma Membrane Cell-cell Junction Focal Adhesion Cell Surface Ruffle Membrane Extracellular Vesicular Exosome
	Molecular Function	Insulin Receptor Binding Integrin Binding Structural Constituent Of Cytoskeleton Protein Binding Vinculin Binding LIM Domain Binding Actin Filament Binding
	Biological Process	Platelet Degranulation Movement Of Cell Or Subcellular Component Muscle Contraction Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Cytoskeletal Anchoring At Plasma Membrane Cell-cell Junction Assembly Cell-substrate Junction Assembly Axon Guidance Blood Coagulation Platelet Activation Cortical Actin Cytoskeleton Organization Endoplasmic Reticulum Unfolded Protein Response Cellular Protein Metabolic Process Platelet Aggregation
Pathways		Axon guidance Semaphorin interactions p130Cas linkage to MAPK signaling for integrins Smooth Muscle Contraction Integrin alphaIIb beta3 signaling Platelet degranulation GRB2:SOS provides linkage to MAPK signaling for Integrins Platelet Aggregation (Plug Formation) XBP1(S) activates chaperone genes IRE1alpha activates chaperones Response to elevated platelet cytosolic Ca2+ SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion Platelet activation, signaling and aggregation Unfolded Protein Response (UPR)
Drugs
Diseases
GWAS
Protein-protein Interactions		23 interactors: ACTA1 CDK5 DAG1 EGFR ERBB2 ITGA1 ITGA2B ITGB1 ITGB2 ITGB3 ITGB5 ITGB7 LRP2 NRAP PKD1 PTK2 PTK2B PXN SMURF1 TES TUBA1A VCL YWHAQ
Entrez ID		7094
HPRD ID		01726
Ensembl ID		ENSG00000137076
Uniprot IDs		Q9Y490
PDB IDs		1SYQ 4DJ9
Enriched GO Terms of Interacting Partners?		Cell-matrix Adhesion Cell-substrate Adhesion Integrin-mediated Signaling Pathway Movement Of Cell Or Subcellular Component Cell Adhesion Cell Morphogenesis Involved In Differentiation Anatomical Structure Morphogenesis Response To External Stimulus Cell Differentiation Axonogenesis Anatomical Structure Development Extracellular Matrix Organization Extracellular Structure Organization Axon Development Cell Morphogenesis Axon Guidance Cell Morphogenesis Involved In Neuron Differentiation Neuron Projection Development Regulation Of Cell Migration Chemotaxis Cell Development Cell Projection Organization Neuron Projection Morphogenesis Regulation Of Cell Motility Developmental Process Multicellular Organismal Development Positive Regulation Of Protein Kinase Activity Regulation Of Locomotion Locomotion Neuron Development Regulation Of Cellular Component Movement Positive Regulation Of Kinase Activity Positive Regulation Of Protein Phosphorylation Regulation Of Phosphorylation Single Organismal Cell-cell Adhesion Regulation Of Protein Phosphorylation Positive Regulation Of Transferase Activity Neuron Differentiation Cell Projection Morphogenesis Nervous System Development Regulation Of Phosphorus Metabolic Process Cell Part Morphogenesis Positive Regulation Of Phosphorylation Wound Healing Positive Regulation Of Protein Modification Process Generation Of Neurons Blood Coagulation Cellular Localization Hemostasis Heterotypic Cell-cell Adhesion
Tagcloud ?		83a adjacent brainstem clu comprehensive correlating dipg dipgs ef2 fresh frozen glioma h3f3a hedgehog hh hist1h3b hypomethylation morbid multidimensional pediatric pontine profiling ptch signatures specimens subgroups supervised talin upregulation