YWHAQ and SLC8A3

Number of citations of the paper that reports this interaction (PubMedID 16679322)
0

Data Source:
HPRD (in vitro)

		YWHAQ	SLC8A3
Description		tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta	solute carrier family 8 member A3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Focal Adhesion Membrane Protein-containing Complex Synapse Extracellular Exosome	Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Centrosome Cytosol Microtubule Plasma Membrane Postsynaptic Density Microtubule Cytoskeleton Membrane Sarcoplasm Axon Dendrite Neuromuscular Junction Sarcolemma Cell Projection Neuronal Cell Body Dendritic Spine Perikaryon Axon Terminus Synapse Postsynaptic Membrane Perinuclear Region Of Cytoplasm Anchoring Junction Postsynapse
	Molecular Function	Protein Binding Protein Domain Specific Binding Identical Protein Binding Transmembrane Transporter Binding 14-3-3 Protein Binding	Calcium:sodium Antiporter Activity Protein Binding Calmodulin Binding Antiporter Activity Calcium:monoatomic Cation Antiporter Activity Metal Ion Binding Calcium:monoatomic Cation Antiporter Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration
	Biological Process	Protein Targeting Signal Transduction Small GTPase-mediated Signal Transduction Intracellular Protein Localization Substantia Nigra Development Negative Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of DNA-templated Transcription	Hematopoietic Progenitor Cell Differentiation Monoatomic Ion Transport Sodium Ion Transport Calcium Ion Transport Mitochondrial Calcium Ion Transmembrane Transport Intracellular Calcium Ion Homeostasis Cell Communication Learning Or Memory Learning Memory Regulation Of Skeletal Muscle Contraction Telencephalon Development Metal Ion Transport Sodium Ion Transmembrane Transport Myelination Oligodendrocyte Differentiation Synapse Organization Mitochondrial Calcium Ion Homeostasis Transmembrane Transport Long-term Synaptic Potentiation Calcium Ion Transport Into Cytosol Calcium Ion Transmembrane Transport Cellular Response To CAMP Cellular Response To Hypoxia Calcium Ion Import Across Plasma Membrane Modulation Of Excitatory Postsynaptic Potential Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Negative Regulation Of Intracellular Signal Transduction Regulation Of Cardiac Conduction Calcium Ion Export Across Plasma Membrane
Pathways		Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane RHO GTPases activate PKNs TP53 Regulates Metabolic Genes Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Regulation of localization of FOXO transcription factors SARS-CoV-1 targets host intracellular signalling and regulatory pathways SARS-CoV-2 targets host intracellular signalling and regulatory pathways	Reduction of cytosolic Ca++ levels Sodium/Calcium exchangers Ion homeostasis Mitochondrial calcium ion transport
Drugs		Phenethyl Isothiocyanate
Diseases
GWAS		Heart rate variability traits ( 22174390) Non-response to selective serotonin reuptake inhibitors and depression ( 27622933)	Bipolar disorder ( 31043756) Corneal curvature ( 22969067) Cystic fibrosis severity ( 21602797) Daytime sleep phenotypes ( 27126917) Metabolite levels ( 23823483)
Interacting Genes		216 interacting genes: AARS2 ABL1 ACSL4 ADRB2 AGTR1 AHCY AKT1S1 ANXA1 ANXA2 AR ARHGAP10 ARHGEF16 ATP5F1A BAD BAX BCAP31 BCR BRAF CABIN1 CAPN3 CBL CBLL1 CCDC125 CDC25A CDC25B CDC25C CDC5L CDK11B CDK14 CDK16 CDKN1A CDKN1B CFL1 CHAF1A CKM CLTC COPS4 CSE1L CSNK1A1 CSNK2A1 CTPS1 DAB2IP DCPS DDX1 DDX3X DHX9 DISC1 DNMT1 DYNC1H1 E2F1 EFNB1 EGFR EIF4A3 ENO1 EPB41 EPB41L1 EPB41L3 ESR1 ESR2 FASN FBLN1 FGR FSCN1 FSHR FXYD1 GAPDH GCN1 H2BC8 H4C14 HADHA HAT1 HAX1 HDAC7 HNRNPC HNRNPH1 HSPA1A HSPA8 HSPB1 HUS1 IARS2 ING1 ITCH ITGB4 KANK1 KCNK15 KCNK3 KCNK9 KIF5B KLC2 KLC3 KRT1 KRT9 LARP1 LARS2 LDHA LIMA1 LMNA LMNB1 LYST MAGOH MAP3K3 MAP3K5 MCM3 MDM4 MED1 MEF2D MPL MPRIP MRPS27 MST1R MTNR1B MTOR MYCBP2 NADK NCL NCOA1 NCOA3 NDE1 NEDD4L NFATC1 NFATC2 NFATC4 NFKB1 NIF3L1 NME7 NOLC1 NUMA1 PABPN1 PANK1 PDCD6 PDE3A PDE3B PDE4B PDK1 PDPK1 PDXK PFKFB2 PFKL PFN1 PGK1 PHLDB2 PI4KB PIK3C3 PIK3CB PKM PRDX1 PRKCQ PRKCZ PRKD1 PRKDC PRMT5 PSME3 RAI14 RCOR3 REM1 RFC1 RGS3 RGS7 RIPK2 RNASE2 RPL10A RPL15 RPL19 RPL7 RPLP0 RPLP2 RPS3 RUVBL2 SAMSN1 SH3BP2 SKIC8 SLC27A2 SLC8A1 SLC8A2 SLC8A3 SMAD9 SNRPE SOCS3 SPR SPTA1 SPTB SRSF3 SSBP1 SSX2IP SUMO2 TCP1 TERT THRA TLN1 TNF TNFAIP3 TPI1 TPR TRAF6 TRIM25 TRIM28 TRIM42 TSC1 TSC2 TUBA1A TUBA3C TUBB UBQLN4 UCP2 UCP3 ULK4 USP8 VARS1 WDR77 WTAP WWC2 WWP1 YAP1 YWHAG ZC3H13 ZHX2	5 interacting genes: GJA8 PPP3CB YWHAB YWHAE YWHAQ
Entrez ID		10971	6547
HPRD ID		00886	09723
Ensembl ID		ENSG00000134308	ENSG00000100678
Uniprot IDs		P27348	B3KU59 P57103
PDB IDs		2BTP 5IQP 6BCR 6BD2 6BQT 6KZG 6KZH
Enriched GO Terms of Interacting Partners?		Cytosol Cytoplasm Regulation Of Signaling Regulation Of Cell Communication Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Multicellular Organismal Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Protein Metabolic Process ATP Binding Regulation Of Cellular Component Organization Regulation Of Primary Metabolic Process Negative Regulation Of Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Regulation Of Programmed Cell Death Positive Regulation Of Metabolic Process Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of Metabolic Process Nucleus Cadherin Binding Kinase Activity Negative Regulation Of Programmed Cell Death Regulation Of Developmental Process Nucleobase-containing Compound Metabolic Process Cellular Response To Stress Nucleotide Binding Regulation Of Biological Quality Regulation Of Macromolecule Metabolic Process Positive Regulation Of Protein Metabolic Process Cell Cortex Cellular Response To Oxygen-containing Compound Response To Stress Protein-containing Complex Glucose Catabolic Process Organelle Organization Positive Regulation Of Multicellular Organismal Process Macromolecule Metabolic Process ADP Metabolic Process RNA Binding Cellular Response To Lipid Positive Regulation Of Cell Communication Positive Regulation Of Signaling Extracellular Exosome Regulation Of Organelle Organization Positive Regulation Of Cell Population Proliferation Glycolytic Process Cellular Response To Hormone Stimulus	Negative Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of Transport Negative Regulation Of Monoatomic Ion Transport Phosphoserine Residue Binding Negative Regulation Of Transmembrane Transport Protein Targeting Protein Domain Specific Binding Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of Calcium Ion Transmembrane Transport Phosphoprotein Binding Protein Phosphatase Inhibitor Activity Protein Sequestering Activity Substantia Nigra Development Negative Regulation Of Protein Localization To Nucleus Negative Regulation Of Calcium Ion Transport Enzyme Binding Regulation Of Monoatomic Ion Transport Neural Nucleus Development Focal Adhesion Regulation Of Protein Transport Negative Regulation Of Cation Transmembrane Transport Regulation Of Establishment Of Protein Localization Regulation Of Cellular Localization Regulation Of Transport Melanosome Regulation Of Nucleocytoplasmic Transport Histone Deacetylase Binding Regulation Of Heart Rate By Hormone Transmembrane Transporter Binding Regulation Of Calcium Ion Transmembrane Transport Regulation Of Intracellular Protein Transport Regulation Of Protein Localization To Nucleus Positive Regulation Of Lysosome Organization Intracellular Signaling Cassette Calmodulin-dependent Protein Phosphatase Activity Regulation Of Protein Localization Regulation Of Heart Rate By Chemical Signal Negative Regulation Of Calcium Ion Export Across Plasma Membrane Negative Regulation Of Protein Localization Gap Junction-mediated Intercellular Transport Negative Regulation Of Calcium Ion Import Across Plasma Membrane Regulation Of Calcium Ion Transport Calcineurin Complex Regulation Of Calcium Ion Export Across Plasma Membrane Locomotion Involved In Locomotory Behavior Positive Regulation Of Protein Transport Positive Regulation Of Toll-like Receptor Signaling Pathway Protein Phosphatase 2B Binding Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Intracellular Transport
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