TLN1 and PXN

Number of citations of the paper that reports this interaction (PubMedID 35831314)
73

Data Source:
BioGRID (pull down, biochemical)
HPRD (in vivo)

		TLN1	PXN
Description		talin 1	paxillin
Image
GO Annotations	Cellular Component	Ruffle Extracellular Region Cytoplasm Cytosol Cytoskeleton Plasma Membrane Adherens Junction Focal Adhesion Cell Surface Membrane Ruffle Membrane Cell Projection Extracellular Exosome Anchoring Junction	Stress Fiber Cytoplasm Cytosol Cytoskeleton Microtubule Associated Complex Plasma Membrane Cell-cell Junction Focal Adhesion Cell Cortex Lamellipodium Anchoring Junction
	Molecular Function	Phosphatidylserine Binding Actin Binding Integrin Binding Structural Constituent Of Cytoskeleton Protein Binding Vinculin Binding LIM Domain Binding Phosphatidylinositol Binding Cadherin Binding Actin Filament Binding	Protein Binding Beta-catenin Binding Vinculin Binding Protein Phosphatase Binding Neuropilin Binding Metal Ion Binding
	Biological Process	Cell-cell Junction Assembly Cell-substrate Junction Assembly Cell Adhesion Integrin-mediated Signaling Pathway Actin Cytoskeleton Organization Cortical Actin Cytoskeleton Organization Integrin Activation Cortical Microtubule Organization Regulation Of Focal Adhesion Assembly Platelet Aggregation Cell-cell Adhesion	Cell Adhesion Signal Transduction Signal Complex Assembly Transforming Growth Factor Beta Receptor Signaling Pathway Cell Migration Substrate Adhesion-dependent Cell Spreading Cellular Response To Reactive Oxygen Species Endothelial Cell Migration Positive Regulation Of Stress Fiber Assembly Growth Hormone Receptor Signaling Pathway
Pathways		Platelet degranulation Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins XBP1(S) activates chaperone genes SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion Smooth Muscle Contraction MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	GAB1 signalosome VEGFA-VEGFR2 Pathway Smooth Muscle Contraction Localization of the PINCH-ILK-PARVIN complex to focal adhesions Regulation of cytoskeletal remodeling and cell spreading by IPP complex components PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) IgE levels in asthmatics ( 23967269) Lymphocyte count ( 32888494) Monocyte count ( 32888494) Platelet distribution width ( 27863252 32888494) Plateletcrit ( 32888494)	Bipolar disorder ( 31043756) Left ventricle wall thickness ( 33495596) Left ventricular end-systolic volume ( 33495596) Left ventricular mass to end-diastolic volume ratio ( 33495596) Mean spheric corpuscular volume ( 32888494) Platelet count ( 29403010)
Interacting Genes		37 interacting genes: ABI1 ACTA1 ARHGAP31 AZIN2 CDK5 CEBPA DAG1 DOK1 EGFR ERBB2 FMO1 HSP90AA1 ITGA1 ITGA2B ITGB1 ITGB2 ITGB3 ITGB5 ITGB7 LRP2 MTNR1A MTNR1B NRAP NYAP1 PIP5K1C PKD1 PTK2 PTK2B PXN RET SMURF1 SUMO2 TES TPTE TUBA1A VCL YWHAQ	86 interacting genes: ABL1 ACO1 AHCY AR ARHGEF7 ASAP1 ASAP2 BCAR1 BCL2 BLK CASP3 CEACAM1 CLTC CREB3L2 CRK CRKL CSK DGUOK DPY30 EPHB1 FYN GART GIT1 GIT2 GRB2 GSK3A GSK3B GSN HDAC6 ILK ITGA4 ITGA6 ITGA9 ITGAV ITGB1 ITGB3 LCK LIMK1 LINC00632 LMO1 LMO3 MAPK1 MAPK3 MAPK8 MATK NCK1 NEDD9 NF2 PABPC1 PAK1 PAK3 PARVA PDPK1 PKD1 PLEKHH2 POLR1D PPP2CA PPP2R5C PTEN PTK2 PTK2B PTPN11 PTPN12 PTPRH RASA1 REPS2 RHOU RNF5 SDC4 SELE SH3RF1 SORBS1 SRC SYK TCEANC TGM2 TLN1 TRIM15 TRIP6 TUBA1B TUBA3C TUBA8 TUBG1 TUBG2 VCL WHRN
Entrez ID		7094	5829
HPRD ID		01726	03937
Ensembl ID		ENSG00000137076	ENSG00000089159
Uniprot IDs		Q9Y490	A0A140VJQ8 A0A1B0GTU4 F5GZ78 P49023
PDB IDs		1SYQ 2MWN 4DJ9 6R9T	1OW6 1OW7 1OW8 2K2R 2O9V 2VZD 2VZG 2VZI 3GM1 3PY7 3RQE 3RQF 3RQG 3U3F 4EDN 4R32 4XGZ 4XH2 5UWH 6IUI 6PW8 6U4M 6U4N 7QB0
Enriched GO Terms of Interacting Partners?		Focal Adhesion Cell-matrix Adhesion Cell-substrate Adhesion Integrin Complex Integrin-mediated Signaling Pathway Cell Migration Receptor Complex Cell Motility Cell Adhesion Cell-cell Adhesion Cell Surface Receptor Signaling Pathway Signal Transduction Cell Adhesion Mediated By Integrin Lamellipodium Enzyme-linked Receptor Protein Signaling Pathway Filopodium Virus Receptor Activity Regulation Of Protein Metabolic Process Cell Surface Anchoring Junction Cell Projection Symbiont Entry Into Host Cell Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Plasma Membrane Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Extracellular Exosome Signal Complex Assembly Developmental Process Integrin Binding Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of Protein Metabolic Process Heterotypic Cell-cell Adhesion Biological Process Involved In Interaction With Host Neuron Projection Morphogenesis Protein Phosphatase Binding Vinculin Binding Cell Projection Morphogenesis Cell Projection Organization Ruffle Membrane Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Wound Healing, Spreading Of Epidermal Cells Integrin Alpha1-beta1 Complex Regulation Of Cell Migration Positive Regulation Of Fibroblast Migration Regulation Of Apoptotic Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell Adhesion Anatomical Structure Morphogenesis Regulation Of Cell-matrix Adhesion Regulation Of Cell Development	Focal Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Cell Adhesion Integrin-mediated Signaling Pathway Cell Migration Regulation Of Cellular Component Organization Cell Surface Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Anchoring Junction Cell Motility Regulation Of Cytoskeleton Organization Regulation Of Cell-substrate Adhesion Positive Regulation Of Cell Adhesion Regulation Of Cell Migration Regulation Of Intracellular Signal Transduction Cytosol Regulation Of Cell Motility Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Migration Regulation Of Locomotion Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Immune Response-regulating Cell Surface Receptor Signaling Pathway ERBB Signaling Pathway Signal Transduction Immune Response-activating Cell Surface Receptor Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Phosphotyrosine Residue Binding Cell-substrate Adhesion Protein Kinase Activity Regulation Of Cell-matrix Adhesion Cell Projection Organization Regulation Of Immune System Process Lamellipodium Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Cellular Component Organization Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Cytoplasm Regulation Of MAPK Cascade Plasma Membrane Regulation Of Cellular Localization Regulation Of Protein Localization Immune Response-activating Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Organelle Organization Kinase Activity Positive Regulation Of Immune System Process Fc-gamma Receptor Signaling Pathway
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