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RNF2 and HIST2H2AC
Number of citations of the paper that reports this interaction (PMID
15386022
)
287
Data Source:
BioGRID
(enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study)
RNF2
HIST2H2AC
Gene Name
ring finger protein 2
histone cluster 2, H2ac
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Ubiquitin Ligase Complex
Euchromatin
Sex Chromatin
Nucleus
Nucleoplasm
Nuclear Body
PcG Protein Complex
PRC1 Complex
MLL1 Complex
Nucleosome
Nucleus
Extracellular Vesicular Exosome
Molecular Function
Chromatin Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Ligase Activity
RING-like Zinc Finger Domain Binding
Molecular_function
DNA Binding
Protein Heterodimerization Activity
Biological Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Mitotic Cell Cycle
Gastrulation With Mouth Forming Second
Transcription, DNA-templated
Anterior/posterior Axis Specification
Histone H2A Monoubiquitination
Histone H2A-K119 Monoubiquitination
Biological_process
Pathways
Oxidative Stress Induced Senescence
Cellular Senescence
RNA Polymerase I Chain Elongation
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
Mitotic Prophase
Regulatory RNA pathways
RNA Polymerase I Promoter Clearance
Deposition of new CENPA-containing nucleosomes at the centromere
Cellular Senescence
Signaling by Wnt
HATs acetylate histones
M Phase
Amyloids
NoRC negatively regulates rRNA expression
Packaging Of Telomere Ends
Telomere Maintenance
Nucleosome assembly
RNF mutants show enhanced WNT signaling and proliferation
XAV939 inhibits tankyrase, stabilizing AXIN
DNA methylation
Transcriptional regulation by small RNAs
Meiotic recombination
DNA Damage/Telomere Stress Induced Senescence
Chromosome Maintenance
HDACs deacetylate histones
Chromatin organization
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
RNA Polymerase I Transcription
formation of the beta-catenin:TCF transactivating complex
Meiotic synapsis
Epigenetic regulation of gene expression
Senescence-Associated Secretory Phenotype (SASP)
Negative epigenetic regulation of rRNA expression
PRC2 methylates histones and DNA
Cell Cycle, Mitotic
RMTs methylate histone arginines
Chromatin modifying enzymes
Oxidative Stress Induced Senescence
TCF dependent signaling in response to WNT
RNA Polymerase I Promoter Opening
SIRT1 negatively regulates rRNA Expression
Signaling by WNT in cancer
Condensation of Prophase Chromosomes
Drugs
Diseases
GWAS
Obesity-related traits (
23251661
)
Protein-Protein Interactions
54 interactors:
ABCB1
AMBRA1
BMI1
CASP3
CASP9
CBX4
CBX6
CBX7
CBX8
HIST1H2AB
HIST2H2AA3
HIST2H2AC
HIST3H3
KAT8
KMT2A
L3MBTL2
MBD1
OTUD6A
PCGF1
PCGF2
PCGF3
PCGF5
PCGF6
PGP
PHB2
PHC1
PSMC4
RING1
RRM1
RYBP
SMURF2
SSX2
TARDBP
TFCP2
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E2
UBE2E3
UBE2H
UBE2J1
UBE2K
UBE2L3
UBE2U
UBE2V1
UBE2V2
UBE2W
UBE3A
USP11
USP19
USP7
WASH1
65 interactors:
ANP32A
ATXN7L3
BAP1
BARD1
BAZ1B
BMI1
BRCA1
CDY1
CHFR
COPRS
CRP
CTCFL
CTDP1
DDB2
DNMT3L
EIF2AK2
EP300
GATAD2A
GATAD2B
HAT1
HDAC2
HIST1H2BA
HIST1H3A
HIST1H4A
HIST2H2BE
HIST2H4A
KAT2A
KAT2B
KAT5
KAT7
MSL2
MYSM1
NAP1L4
NCAPH
NCL
NPM1
PARP10
PBRM1
PELP1
PRMT5
PRMT7
RAG1
RBBP4
RCC1
RNF168
RNF2
RNF20
RNF8
SART3
SIRT7
SSRP1
TAF15
TAF1A
TAF1B
TCF20
TSPY1
TSSK6
UBC
UBE2B
UBR2
UIMC1
USP12
USP16
USP22
USP46
Entrez ID
6045
8338
HPRD ID
07028
09107
Ensembl ID
ENSG00000121481
ENSG00000184260
Uniprot IDs
B3KRH1
Q99496
Q16777
PDB IDs
2H0D
3GS2
3H8H
3IXS
3RPG
Enriched GO Terms of Interacting Partners
?
Protein Modification By Small Protein Conjugation
Protein Ubiquitination
Protein Polyubiquitination
Protein K48-linked Ubiquitination
Cellular Protein Modification Process
Histone Ubiquitination
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Protein K11-linked Ubiquitination
Cellular Protein Catabolic Process
Chromatin Modification
Cellular Macromolecule Catabolic Process
Protein Catabolic Process
Cellular Metabolic Process
Chromatin Organization
Cellular Protein Metabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Transcription, DNA-templated
Chromosome Organization
Histone Modification
RNA Biosynthetic Process
Protein Metabolic Process
Nucleobase-containing Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Proteolysis
Protein Monoubiquitination
Negative Regulation Of RNA Biosynthetic Process
Nitrogen Compound Metabolic Process
Regulation Of Nitrogen Compound Metabolic Process
Catabolic Process
Cellular Macromolecule Biosynthetic Process
Negative Regulation Of Transcription, DNA-templated
Protein K63-linked Ubiquitination
Macromolecule Biosynthetic Process
Metabolic Process
Regulation Of Transcription, DNA-templated
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of Gene Expression
Regulation Of Nucleic Acid-templated Transcription
Gene Expression
Regulation Of Metabolic Process
Regulation Of RNA Biosynthetic Process
Negative Regulation Of Biosynthetic Process
RNA Metabolic Process
Regulation Of RNA Metabolic Process
Regulation Of Gene Expression
Chromatin Organization
Chromosome Organization
Chromatin Modification
Histone Modification
Organelle Organization
Regulation Of Gene Expression
Nucleobase-containing Compound Metabolic Process
Regulation Of RNA Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Protein Modification Process
Regulation Of RNA Biosynthetic Process
Cellular Nitrogen Compound Metabolic Process
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Histone Ubiquitination
Regulation Of Gene Expression, Epigenetic
Regulation Of Nitrogen Compound Metabolic Process
Nitrogen Compound Metabolic Process
DNA Metabolic Process
Transcription, DNA-templated
RNA Biosynthetic Process
Negative Regulation Of Gene Expression
Cellular Protein Metabolic Process
Gene Expression
Chromatin Remodeling
Regulation Of Metabolic Process
Chromatin Silencing
Cellular Metabolic Process
DNA Packaging
Nucleosome Organization
Protein Metabolic Process
Negative Regulation Of Transcription, DNA-templated
Chromatin Assembly Or Disassembly
Negative Regulation Of Nucleic Acid-templated Transcription
Histone H2A Ubiquitination
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Gene Expression, Epigenetic
Histone Acetylation
Nucleosome Assembly
RNA Metabolic Process
Protein-DNA Complex Assembly
Internal Peptidyl-lysine Acetylation
Negative Regulation Of Cellular Metabolic Process
Peptidyl-lysine Acetylation
Internal Protein Amino Acid Acetylation
Negative Regulation Of Biosynthetic Process
Cell Cycle
Histone Deubiquitination
Chromatin Assembly
Tagcloud
?
aldrich
ambra1
arp2
associates
autophagy
becn1
cul4a
ddb1
e3
elusive
endosomal
impairs
impede
interactor
k48
k63
ligase
linkage
pik3c3
potentiates
scar
sorting
starvation
suppresses
ubiquitinate
ubiquitination
wash
wasp
wiskott
Tagcloud (Difference)
?
aldrich
ambra1
arp2
associates
autophagy
becn1
cul4a
ddb1
e3
elusive
endosomal
impairs
impede
interactor
k48
k63
ligase
linkage
pik3c3
potentiates
scar
sorting
starvation
suppresses
ubiquitinate
ubiquitination
wash
wasp
wiskott
Tagcloud (Intersection)
?