RNF2 and PCGF2

Number of citations of the paper that reports this interaction (PubMedID 12183370)
0

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		RNF2	PCGF2
Description		ring finger protein 2	polycomb group ring finger 2
Image			No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Euchromatin Heterochromatin Sex Chromatin Nucleus Nucleoplasm Chromosome Cytoplasm Nuclear Body PcG Protein Complex PRC1 Complex MLL1 Complex	Chromatin Sex Chromatin Nucleus Nucleoplasm Nuclear Body PcG Protein Complex PRC1 Complex
	Molecular Function	Chromatin Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity RING-like Zinc Finger Domain Binding Histone H2AK119 Ubiquitin Ligase Activity	DNA Binding Chromatin Binding Protein Binding Zinc Ion Binding Metal Ion Binding Promoter-specific Chromatin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Mitotic Cell Cycle Gastrulation With Mouth Forming Second Chromatin Organization Chromatin Remodeling Germ Cell Development Anterior/posterior Axis Specification Gene Expression Protein Ubiquitination Epigenetic Regulation Of Gene Expression Negative Regulation Of DNA-binding Transcription Factor Activity	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Chromatin Organization Chromatin Remodeling Anterior/posterior Pattern Specification Embryonic Skeletal System Morphogenesis Embryonic Skeletal System Development Cellular Response To Hydrogen Peroxide Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Signaling Pathway
Pathways		Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6	SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins Activation of anterior HOX genes in hindbrain development during early embryogenesis Transcriptional Regulation by E2F6
Drugs
Diseases
GWAS		Clopidogrel active metabolite levels ( 28207573) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Obesity-related traits ( 23251661)
Interacting Genes		65 interacting genes: ABCB1 AMBRA1 BAALC BMI1 CASP3 CASP9 CBX4 CBX6 CBX7 CBX8 CIP2A DYSF ERG GMNN H2AC18 H2AC20 H2AC4 H2BC3 H3-4 KAT8 KMT2A MBD1 MTNR1A OTUD6A PCGF1 PCGF2 PCGF6 PGP PHB2 PHC1 PHC2 PLK1 PSMC4 RING1 RRM1 RYBP SBDS SCMH1 SIK1 SMURF2 SSX2 TARDBP TFCP2 TMEM132D TSC22D2 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2J1 UBE2K UBE2L3 UBE2U UBE2V1 UBE2V2 UBE2W UBE3A USP11 USP19 WASHC1	26 interacting genes: ABHD6 AKT1 CBX6 CCND2 CD247 CDK2 CTNNAL1 GJB5 HOXC9 HSF2 LMNA OGT PELI2 RBCK1 RNF2 SPDEF STX2 SUMO3 TRAF2 UBE2D3 UBE2E2 UBE2Q2 UBE2T UBE2U USP11 USP7
Entrez ID		6045	7703
HPRD ID		07028	10621
Ensembl ID		ENSG00000121481	ENSG00000277258
Uniprot IDs		Q99496	P35227
PDB IDs		2H0D 3GS2 3H8H 3IXS 3RPG 4R8P 4S3O 6WI7 6WI8 7ND1 8GRM 8PP7 9DBY 9DDE 9DGG
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity PRC1 Complex PcG Protein Complex Post-translational Protein Modification Protein Polyubiquitination Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein Modification Process Nucleus Protein K48-linked Ubiquitination Ubiquitin-protein Transferase Activity Negative Regulation Of Biosynthetic Process Chromatin Organization Negative Regulation Of Macromolecule Biosynthetic Process Protein K11-linked Ubiquitination Nucleoplasm Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Proteolysis Negative Regulation Of Macromolecule Metabolic Process Chromatin Remodeling Protein Metabolic Process Modification-dependent Protein Catabolic Process Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Ubiquitin-dependent Protein Catabolic Process Ubiquitin-protein Transferase Activator Activity Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Macromolecule Catabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Protein Ubiquitination Chromatin Binding Positive Regulation Of Post-translational Protein Modification Regulation Of Protein Ubiquitination Transferase Activity Heterochromatin Formation Heterochromatin Proteasomal Protein Catabolic Process Sex Chromatin Protein Monoubiquitination Negative Regulation Of Transcription By RNA Polymerase II	Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Polyubiquitination Protein Ubiquitination Protein Modification Process Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activity Protein K11-linked Ubiquitination Transferase Activity TORC1 Signaling Protein Metabolic Process Protein K6-linked Ubiquitination TOR Signaling Protein K48-linked Ubiquitination Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Cellular Response To Stress Protein Monoubiquitination Macromolecule Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Ubiquitin-dependent Protein Catabolic Process Nucleoplasm Protein K29-linked Ubiquitination Regulation Of Cell Cycle G1/S Phase Transition Regulation Of DNA-binding Transcription Factor Activity Protein Autoubiquitination Ubiquitin Protein Ligase Activity Protein K63-linked Ubiquitination Regulation Of Proteasomal Protein Catabolic Process Cellular Response To Nitric Oxide Cellular Response To Reactive Nitrogen Species Negative Regulation Of Release Of Cytochrome C From Mitochondria Negative Regulation Of Metabolic Process Regulation Of Protein Localization PRC1 Complex Positive Regulation Of Protein Localization To Cell Surface Ubiquitin-like Protein Transferase Activity Positive Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of TORC1 Signaling Regulation Of Glucose Metabolic Process Response To Nitric Oxide Positive Regulation Of Lipid Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Cell Cycle Phase Transition PcG Protein Complex Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process
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