RNF2 and OTUD6A

Number of citations of the paper that reports this interaction (PMID 23105109)
4

Data Source:
BioGRID (two hybrid)

		RNF2	OTUD6A
Gene Name		ring finger protein 2	OTU deubiquitinase 6A
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Euchromatin Sex Chromatin Nucleus Nucleoplasm Nuclear Body PcG Protein Complex PRC1 Complex MLL1 Complex
	Molecular Function	Chromatin Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity RING-like Zinc Finger Domain Binding	Ubiquitin-specific Protease Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Cell Cycle Gastrulation With Mouth Forming Second Transcription, DNA-templated Anterior/posterior Axis Specification Histone H2A Monoubiquitination Histone H2A-K119 Monoubiquitination	Proteolysis Protein K29-linked Deubiquitination Protein K11-linked Deubiquitination Protein K27-linked Deubiquitination Protein K33-linked Deubiquitination
Pathways		Oxidative Stress Induced Senescence Cellular Senescence
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		54 interactors: ABCB1 AMBRA1 BMI1 CASP3 CASP9 CBX4 CBX6 CBX7 CBX8 HIST1H2AB HIST2H2AA3 HIST2H2AC HIST3H3 KAT8 KMT2A L3MBTL2 MBD1 OTUD6A PCGF1 PCGF2 PCGF3 PCGF5 PCGF6 PGP PHB2 PHC1 PSMC4 RING1 RRM1 RYBP SMURF2 SSX2 TARDBP TFCP2 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2J1 UBE2K UBE2L3 UBE2U UBE2V1 UBE2V2 UBE2W UBE3A USP11 USP19 USP7 WASH1	7 interactors: CBLC RBCK1 RNF2 TRIM39 TRIM46 TRIM5 UBC
Entrez ID		6045	139562
HPRD ID		07028	13681
Ensembl ID		ENSG00000121481	ENSG00000189401
Uniprot IDs		B3KRH1 Q99496	Q7L8S5
PDB IDs		2H0D 3GS2 3H8H 3IXS 3RPG
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein Polyubiquitination Protein K48-linked Ubiquitination Cellular Protein Modification Process Histone Ubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Protein K11-linked Ubiquitination Cellular Protein Catabolic Process Chromatin Modification Cellular Macromolecule Catabolic Process Protein Catabolic Process Cellular Metabolic Process Chromatin Organization Cellular Protein Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Transcription, DNA-templated Chromosome Organization Histone Modification RNA Biosynthetic Process Protein Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Proteolysis Protein Monoubiquitination Negative Regulation Of RNA Biosynthetic Process Nitrogen Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Catabolic Process Cellular Macromolecule Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Protein K63-linked Ubiquitination Macromolecule Biosynthetic Process Metabolic Process Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Gene Expression Regulation Of Nucleic Acid-templated Transcription Gene Expression Regulation Of Metabolic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process RNA Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression	Protein Ubiquitination Protein Modification By Small Protein Conjugation Positive Regulation Of NF-kappaB Transcription Factor Activity Cellular Protein Modification Process Protein Polyubiquitination Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cellular Protein Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Immune Response-regulating Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Protein Metabolic Process Regulation Of ERBB Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Signaling Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Viral Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Negative Regulation Of Protein Ubiquitination Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death T Cell Receptor Signaling Pathway Protein Catabolic Process Positive Regulation Of Cell Death Regulation Of MAPK Cascade Positive Regulation Of Immune Response Regulation Of Intracellular Signal Transduction Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Histone H2A-K119 Monoubiquitination Antigen Receptor-mediated Signaling Pathway Activation Of Innate Immune Response Protein Linear Polyubiquitination Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Cellular Macromolecule Catabolic Process Positive Regulation Of Innate Immune Response Regulation Of Immune Response Negative Regulation Of Protein Metabolic Process Positive Regulation Of Immune System Process Regulation Of Metabolic Process Positive Regulation Of Apoptotic Signaling Pathway
Tagcloud ?		aldrich ambra1 arp2 associates autophagy becn1 cul4a ddb1 e3 elusive endosomal impairs impede interactor k48 k63 ligase linkage pik3c3 potentiates scar sorting starvation suppresses ubiquitinate ubiquitination wash wasp wiskott
Tagcloud (Difference) ?		aldrich ambra1 arp2 associates autophagy becn1 cul4a ddb1 e3 elusive endosomal impairs impede interactor k48 k63 ligase linkage pik3c3 potentiates scar sorting starvation suppresses ubiquitinate ubiquitination wash wasp wiskott
Tagcloud (Intersection) ?