RNF2 and H2AC4

Number of citations of the paper that reports this interaction (PubMedID 34321665)
80

Data Source:
BioGRID (enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study)

		RNF2	H2AC4
Description		ring finger protein 2	H2A clustered histone 4
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Euchromatin Heterochromatin Sex Chromatin Nucleus Nucleoplasm Chromosome Cytoplasm Nuclear Body PcG Protein Complex PRC1 Complex MLL1 Complex	Nucleosome Nucleus Chromosome CENP-A Containing Nucleosome Extracellular Exosome
	Molecular Function	Chromatin Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity RING-like Zinc Finger Domain Binding Histone H2AK119 Ubiquitin Ligase Activity	DNA Binding Protein Binding Structural Constituent Of Chromatin Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Mitotic Cell Cycle Gastrulation With Mouth Forming Second Chromatin Organization Chromatin Remodeling Germ Cell Development Anterior/posterior Axis Specification Gene Expression Protein Ubiquitination Epigenetic Regulation Of Gene Expression Negative Regulation Of DNA-binding Transcription Factor Activity	Chromatin Organization Negative Regulation Of Cell Population Proliferation Heterochromatin Formation Protein Localization To CENP-A Containing Chromatin
Pathways		Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6	Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence HDACs deacetylate histones HATs acetylate histones HATs acetylate histones RMTs methylate histone arginines SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 UCH proteinases Ub-specific processing proteases Metalloprotease DUBs Deposition of new CENPA-containing nucleosomes at the centromere Assembly of the ORC complex at the origin of replication RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Inhibition of DNA recombination at telomere Defective pyroptosis Negative Regulation of CDH1 Gene Transcription Amyloid fiber formation Chromatin modifications during the maternal to zygotic transition (MZT) MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Regulation of PD-L1(CD274) transcription
Drugs
Diseases
GWAS		Clopidogrel active metabolite levels ( 28207573) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Obesity-related traits ( 23251661)
Interacting Genes		65 interacting genes: ABCB1 AMBRA1 BAALC BMI1 CASP3 CASP9 CBX4 CBX6 CBX7 CBX8 CIP2A DYSF ERG GMNN H2AC18 H2AC20 H2AC4 H2BC3 H3-4 KAT8 KMT2A MBD1 MTNR1A OTUD6A PCGF1 PCGF2 PCGF6 PGP PHB2 PHC1 PHC2 PLK1 PSMC4 RING1 RRM1 RYBP SBDS SCMH1 SIK1 SMURF2 SSX2 TARDBP TFCP2 TMEM132D TSC22D2 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2J1 UBE2K UBE2L3 UBE2U UBE2V1 UBE2V2 UBE2W UBE3A USP11 USP19 WASHC1	49 interacting genes: ACE2 ANAPC11 BAP1 BARD1 BMI1 BRCA1 CDK1 CDK2 CHD4 COMMD4 CREBBP DTX3L EIF2AK2 EP300 EZH2 FANCD2 H2BC15 KAT2A KAT2B KAT5 KMT2A KMT2C KMT2D MAP4K1 MYB PCGF1 PRMT5 PSMD4 PTEN RAD18 RING1 RNF168 RNF169 RNF2 RNF20 RNF40 RNF8 RPL6 TP53BP1 TRIM37 TSPYL5 UBE2D3 UBE2N UFL1 UHRF1 USP16 USP2 USP22 USP51
Entrez ID		6045	8335
HPRD ID		07028	09105
Ensembl ID		ENSG00000121481	ENSG00000278463
Uniprot IDs		Q99496	P04908 Q08AJ9
PDB IDs		2H0D 3GS2 3H8H 3IXS 3RPG 4R8P 4S3O 6WI7 6WI8 7ND1 8GRM 8PP7 9DBY 9DDE 9DGG	2CV5 2RVQ 3A6N 3AFA 3AN2 3AV1 3AV2 3AYW 3AZE 3AZF 3AZG 3AZH 3AZI 3AZJ 3AZK 3AZL 3AZM 3AZN 3W96 3W97 3W98 3W99 3WKJ 3WTP 3X1S 3X1V 4YM5 4YM6 4Z5T 5AV5 5AV6 5AV8 5AV9 5AVB 5AVC 5AY8 5B0Y 5B0Z 5B24 5B2I 5B2J 5B31 5B32 5B40 5CPI 5CPJ 5CPK 5GSE 5GTC 5GXQ 5JRG 5X7X 5XF3 5XF4 5XF5 5Y0C 5Y0D 5Z23 5ZBX 6A5L 6A5O 6A5P 6A5R 6A5T 6A5U 6ACL 6AEE 6BUZ 6E0C 6E0P 6HKT 6HTS 6INQ 6IPU 6IQ4 6IR9 6J4W 6J4X 6J4Y 6J4Z 6J50 6J51 6JR0 6JR1 6JXD 6KE9 6KXV 6L49 6L4A 6L9H 6L9Z 6LA2 6LA8 6LA9 6LAB 6LE9 6LER 6M3V 6M44 6O1D 6R8Y 6R8Z 6R90 6R91 6R92 6R93 6R94 6T79 6T7A 6T7B 6T7C 6T7D 6T90 6T93 6USJ 6V2K 6V92 6YOV 7BWD 7BXT 7BY0 7C0M 7CCQ 7CCR 7COW 7D1Z 7D20 7DBP 7K5X 7K5Y 7K60 7K61 7K63 7LYA 7LYB 7LYC 7NL0 7PET 7PEU 7PEV 7PEW 7PEX 7PEY 7PEZ 7PF0 7PF2 7PF3 7PF4 7PF5 7PF6 7PFA 7PFC 7PFD 7PFE 7PFF 7PFT 7PFU 7PFV 7PFW 7PFX 7SCY 7SCZ 7V90 7V96 7V99 7V9C 7V9J 7V9K 7V9S 7VA4 7VCL 7VZ4 7W9V 7WBV 7WBW 7WBX 7XCR 7XCT 7XD0 7XD1 7XSE 7XSX 7XSZ 7XT7 7XTD 7XTI 7XVL 7XVM 7XX5 7XX6 7XZX 7XZY 7XZZ 7Y00 7Y7I 7ZI4 8G57 8GRM 8H0V 8H0W 8HAG 8HAH 8HAI 8HAJ 8HAK 8HAL 8HAM 8HAN 8HE5 8HQY 8HR1 8I17 8IEG 8IEJ 8IHL 8JBX 8JCC 8JCD 8JH2 8JH3 8JH4 8JHG 8JL9 8JLA 8JLB 8JLD 8JND 8JNE 8JNF 8KB5 8KCY 8KD1 8KE0 8OSJ 8OSK 8OSL 8OTS 8OTT 8Q36 8Q3E 8Q3M 8Q3X 8RGM 8SMW 8SMX 8SMY 8SMZ 8SN0 8SN1 8SN2 8SN3 8SN4 8SN5 8SN6 8SN7 8SN8 8SN9 8SNA 8TXV 8TXW 8TXX 8U13 8U14 8UPF 8UQ8 8UQ9 8UQA 8UQB 8UQC 8UQD 8UQE 8VFX 8VFY 8VFZ 8VG0 8VG1 8VG2 8VLR 8W9D 8W9E 8W9F 8WG5 8X7I 8XBT 8XBU 8Y3C 8Y3D 8Y3E 8Y3F 8YBJ 8YBK 8YNY 8YTI 8YV8 9IPU 9J0N 9J0O 9J0P 9J8M 9J8N 9J8O
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity PRC1 Complex PcG Protein Complex Post-translational Protein Modification Protein Polyubiquitination Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein Modification Process Nucleus Protein K48-linked Ubiquitination Ubiquitin-protein Transferase Activity Negative Regulation Of Biosynthetic Process Chromatin Organization Negative Regulation Of Macromolecule Biosynthetic Process Protein K11-linked Ubiquitination Nucleoplasm Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Proteolysis Negative Regulation Of Macromolecule Metabolic Process Chromatin Remodeling Protein Metabolic Process Modification-dependent Protein Catabolic Process Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Ubiquitin-dependent Protein Catabolic Process Ubiquitin-protein Transferase Activator Activity Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Macromolecule Catabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Protein Ubiquitination Chromatin Binding Positive Regulation Of Post-translational Protein Modification Regulation Of Protein Ubiquitination Transferase Activity Heterochromatin Formation Heterochromatin Proteasomal Protein Catabolic Process Sex Chromatin Protein Monoubiquitination Negative Regulation Of Transcription By RNA Polymerase II	Chromatin Remodeling Chromatin Organization Protein Modification Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Protein Metabolic Process Post-translational Protein Modification Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Regulation Of RNA Metabolic Process Transferase Activity Regulation Of Cell Cycle Chromatin Binding Nucleus DNA Repair Regulation Of Primary Metabolic Process DNA Damage Response Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Ubiquitin-protein Transferase Activity Negative Regulation Of Metabolic Process Negative Regulation Of Cell Cycle Process Epigenetic Regulation Of Gene Expression Ubiquitin Protein Ligase Activity Regulation Of Gene Expression Regulation Of Cell Cycle Process Double-strand Break Repair DNA Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of DNA Repair Cellular Response To Stress Regulation Of Macromolecule Biosynthetic Process Zinc Ion Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Ubiquitin Ligase Complex Negative Regulation Of Cell Cycle Regulation Of Cellular Response To Stress Positive Regulation Of Metabolic Process Transcription Coactivator Activity Histone Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein Modification By Small Protein Conjugation Regulation Of DNA Metabolic Process Protein Ubiquitination
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