RNF2 and UBE2E1

Number of citations of the paper that reports this interaction (PubMedID 28073915)
47

Data Source:
BioGRID (affinity chromatography technology, pull down, pull down, two hybrid)

		RNF2	UBE2E1
Description		ring finger protein 2	ubiquitin conjugating enzyme E2 E1
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Euchromatin Heterochromatin Sex Chromatin Nucleus Nucleoplasm Chromosome Cytoplasm Nuclear Body PcG Protein Complex PRC1 Complex MLL1 Complex	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytosol
	Molecular Function	Chromatin Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity RING-like Zinc Finger Domain Binding Histone H2AK119 Ubiquitin Ligase Activity	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity ISG15 Transferase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Mitotic Cell Cycle Gastrulation With Mouth Forming Second Chromatin Organization Chromatin Remodeling Germ Cell Development Anterior/posterior Axis Specification Gene Expression Protein Ubiquitination Epigenetic Regulation Of Gene Expression Negative Regulation Of DNA-binding Transcription Factor Activity	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Negative Regulation Of Gene Expression Protein Ubiquitination ISG15-protein Conjugation Positive Regulation Of Transcription By RNA Polymerase II Protein K48-linked Ubiquitination
Pathways		Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6	ISG15 antiviral mechanism Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) Assembly of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Synthesis of active ubiquitin: roles of E1 and E2 enzymes E3 ubiquitin ligases ubiquitinate target proteins Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Clopidogrel active metabolite levels ( 28207573) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Obesity-related traits ( 23251661)	Academic attainment (English) ( 33594131) Acne (severe) ( 24927181) Extremely high intelligence ( 29520040) Metabolite levels ( 23823483)
Interacting Genes		65 interacting genes: ABCB1 AMBRA1 BAALC BMI1 CASP3 CASP9 CBX4 CBX6 CBX7 CBX8 CIP2A DYSF ERG GMNN H2AC18 H2AC20 H2AC4 H2BC3 H3-4 KAT8 KMT2A MBD1 MTNR1A OTUD6A PCGF1 PCGF2 PCGF6 PGP PHB2 PHC1 PHC2 PLK1 PSMC4 RING1 RRM1 RYBP SBDS SCMH1 SIK1 SMURF2 SSX2 TARDBP TFCP2 TMEM132D TSC22D2 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2J1 UBE2K UBE2L3 UBE2U UBE2V1 UBE2V2 UBE2W UBE3A USP11 USP19 WASHC1	116 interacting genes: ARIH2 ARK2C ASXL2 BARD1 BIRC7 BIRC8 BRCA1 CADPS2 CBL CHFR CNOT4 CUL3 DTX1 DTX3 DTX3L DZIP3 EPS15 F12 FBXO2 FBXO7 HDAC6 IPO11 ITCH JADE1 LRSAM1 MAP3K1 MARCHF2 MARCHF3 MARCHF5 MARCHF7 MDM2 MGRN1 MID1 MKRN3 MUL1 NEDD4 NEDD4L NHLRC1 PAEP PBX2 POLL POLM PRKN RBX1 RELA RFWD3 RLIM RMND5B RNF10 RNF103 RNF11 RNF111 RNF114 RNF115 RNF122 RNF128 RNF13 RNF130 RNF14 RNF150 RNF152 RNF166 RNF167 RNF168 RNF169 RNF181 RNF185 RNF2 RNF20 RNF26 RNF31 RNF34 RNF4 RNF43 RNF5 RNF8 STUB1 TOPORS TRAF6 TRIM13 TRIM17 TRIM2 TRIM21 TRIM23 TRIM27 TRIM28 TRIM29 TRIM3 TRIM32 TRIM33 TRIM37 TRIM38 TRIM39 TRIM45 TRIM50 TRIM69 TRIM7 UBA1 UBA6 UBA7 UBASH3B UBC UBE2G1 UBE3A UBOX5 UBR5 UBR7 UFM1 USP7 UVSSA WWP2 XIAP ZNG1E ZNRF1 ZNRF2 ZNRF4
Entrez ID		6045	7324
HPRD ID		07028	04225
Ensembl ID		ENSG00000121481	ENSG00000170142
Uniprot IDs		Q99496	B7Z306 P51965
PDB IDs		2H0D 3GS2 3H8H 3IXS 3RPG 4R8P 4S3O 6WI7 6WI8 7ND1 8GRM 8PP7 9DBY 9DDE 9DGG	1XR9 3BZH 4JJQ 5LBN 6FGA 8IYA
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity PRC1 Complex PcG Protein Complex Post-translational Protein Modification Protein Polyubiquitination Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein Modification Process Nucleus Protein K48-linked Ubiquitination Ubiquitin-protein Transferase Activity Negative Regulation Of Biosynthetic Process Chromatin Organization Negative Regulation Of Macromolecule Biosynthetic Process Protein K11-linked Ubiquitination Nucleoplasm Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Proteolysis Negative Regulation Of Macromolecule Metabolic Process Chromatin Remodeling Protein Metabolic Process Modification-dependent Protein Catabolic Process Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Ubiquitin-dependent Protein Catabolic Process Ubiquitin-protein Transferase Activator Activity Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Macromolecule Catabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Protein Ubiquitination Chromatin Binding Positive Regulation Of Post-translational Protein Modification Regulation Of Protein Ubiquitination Transferase Activity Heterochromatin Formation Heterochromatin Proteasomal Protein Catabolic Process Sex Chromatin Protein Monoubiquitination Negative Regulation Of Transcription By RNA Polymerase II	Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Modification Process Protein Polyubiquitination Transferase Activity Protein Metabolic Process Zinc Ion Binding Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Proteolysis Metal Ion Binding Macromolecule Metabolic Process Protein Autoubiquitination Catabolic Process Protein K48-linked Ubiquitination Protein K63-linked Ubiquitination Proteasomal Protein Catabolic Process Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Ubiquitin Ligase Complex Cellular Response To Stress Ubiquitin Protein Ligase Binding Response To Stress Regulation Of Post-translational Protein Modification Cytoplasm Positive Regulation Of Catabolic Process Ubiquitin Binding Positive Regulation Of Post-translational Protein Modification Positive Regulation Of Protein Ubiquitination Positive Regulation Of Autophagy DNA Damage Response Positive Regulation Of Protein Metabolic Process Regulation Of Protein Ubiquitination Protein K6-linked Ubiquitination Negative Regulation Of Signal Transduction Innate Immune Response Regulation Of Signal Transduction Immune System Process Positive Regulation Of Metabolic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Protein Catabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Signaling
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