HIST2H2AC and BAP1

Number of citations of the paper that reports this interaction (PMID 20436459)
84

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		HIST2H2AC	BAP1
Gene Name		histone cluster 2, H2ac	BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleosome Nucleus Extracellular Vesicular Exosome	Nucleus Nucleoplasm Cytoplasm PR-DUB Complex
	Molecular Function	Molecular_function DNA Binding Protein Heterodimerization Activity	Chromatin Binding Ubiquitin-specific Protease Activity Protein Binding Peptidase Activity
	Biological Process	Biological_process	Regulation Of Cell Growth Cellular Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cell Proliferation Protein Deubiquitination Monoubiquitinated Protein Deubiquitination Monoubiquitinated Histone H2A Deubiquitination Regulation Of Cell Cycle Protein K48-linked Deubiquitination
Pathways		RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mitotic Prophase Regulatory RNA pathways RNA Polymerase I Promoter Clearance Deposition of new CENPA-containing nucleosomes at the centromere Cellular Senescence Signaling by Wnt HATs acetylate histones M Phase Amyloids NoRC negatively regulates rRNA expression Packaging Of Telomere Ends Telomere Maintenance Nucleosome assembly RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN DNA methylation Transcriptional regulation by small RNAs Meiotic recombination DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance HDACs deacetylate histones Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling RNA Polymerase I Transcription formation of the beta-catenin:TCF transactivating complex Meiotic synapsis Epigenetic regulation of gene expression Senescence-Associated Secretory Phenotype (SASP) Negative epigenetic regulation of rRNA expression PRC2 methylates histones and DNA Cell Cycle, Mitotic RMTs methylate histone arginines Chromatin modifying enzymes Oxidative Stress Induced Senescence TCF dependent signaling in response to WNT RNA Polymerase I Promoter Opening SIRT1 negatively regulates rRNA Expression Signaling by WNT in cancer Condensation of Prophase Chromosomes
Drugs
Diseases
GWAS			Bipolar disorder ( 21926972)
Protein-Protein Interactions		65 interactors: ANP32A ATXN7L3 BAP1 BARD1 BAZ1B BMI1 BRCA1 CDY1 CHFR COPRS CRP CTCFL CTDP1 DDB2 DNMT3L EIF2AK2 EP300 GATAD2A GATAD2B HAT1 HDAC2 HIST1H2BA HIST1H3A HIST1H4A HIST2H2BE HIST2H4A KAT2A KAT2B KAT5 KAT7 MSL2 MYSM1 NAP1L4 NCAPH NCL NPM1 PARP10 PBRM1 PELP1 PRMT5 PRMT7 RAG1 RBBP4 RCC1 RNF168 RNF2 RNF20 RNF8 SART3 SIRT7 SSRP1 TAF15 TAF1A TAF1B TCF20 TSPY1 TSSK6 UBC UBE2B UBR2 UIMC1 USP12 USP16 USP22 USP46	10 interactors: BRCA1 HIST2H2AA3 HIST2H2AC TRIM63 UBE2O USP15 USP2 USP21 USP28 YY1
Entrez ID		8338	8314
HPRD ID		09107	04366
Ensembl ID		ENSG00000184260	ENSG00000163930
Uniprot IDs		Q16777	Q92560
PDB IDs
Enriched GO Terms of Interacting Partners?		Chromatin Organization Chromosome Organization Chromatin Modification Histone Modification Organelle Organization Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Protein Modification Process Regulation Of RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Histone Ubiquitination Regulation Of Gene Expression, Epigenetic Regulation Of Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process DNA Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Negative Regulation Of Gene Expression Cellular Protein Metabolic Process Gene Expression Chromatin Remodeling Regulation Of Metabolic Process Chromatin Silencing Cellular Metabolic Process DNA Packaging Nucleosome Organization Protein Metabolic Process Negative Regulation Of Transcription, DNA-templated Chromatin Assembly Or Disassembly Negative Regulation Of Nucleic Acid-templated Transcription Histone H2A Ubiquitination Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression, Epigenetic Histone Acetylation Nucleosome Assembly RNA Metabolic Process Protein-DNA Complex Assembly Internal Peptidyl-lysine Acetylation Negative Regulation Of Cellular Metabolic Process Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Negative Regulation Of Biosynthetic Process Cell Cycle Histone Deubiquitination Chromatin Assembly	Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein Deubiquitination Protein Modification By Small Protein Removal Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Cellular Macromolecule Catabolic Process Regulation Of Protein Catabolic Process Response To Radiation Histone Deubiquitination Response To Abiotic Stimulus Cellular Protein Modification Process Regulation Of Proteolysis Proteolysis Cellular Response To UV Response To Light Stimulus Catabolic Process Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H4-K16 Acetylation Cellular Protein Metabolic Process Double-strand Break Repair Via Homologous Recombination Recombinational Repair Regulation Of Cellular Protein Metabolic Process Cellular Response To Light Stimulus Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Histone H3-K9 Acetylation Histone H2B Conserved C-terminal Lysine Deubiquitination Response To Prostaglandin F Signal Transduction By P53 Class Mediator Regulation Of Protein Metabolic Process Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation Response To UV Protein Ubiquitination Cellular Response To Radiation DNA Repair Response To Ionizing Radiation Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Protein Modification By Small Protein Conjugation Double-strand Break Repair DNA Damage Checkpoint Cellular Response To Indole-3-methanol Protein Metabolic Process Protein Polyubiquitination Negative Regulation Of Centriole Replication Skeletal Muscle Atrophy
Tagcloud ?			1000x abstracted arid1a cca cdkn2a cholangiocarcinoma entities extrahepatic fbxw7 fgfr gas hiseq hotspot idh1 illumina indolent intrahepatic introns kras mcl1 ngs pbrm1 pgm presentations radiologic sequencer smad4 targetable worse
Tagcloud (Difference) ?			1000x abstracted arid1a cca cdkn2a cholangiocarcinoma entities extrahepatic fbxw7 fgfr gas hiseq hotspot idh1 illumina indolent intrahepatic introns kras mcl1 ngs pbrm1 pgm presentations radiologic sequencer smad4 targetable worse
Tagcloud (Intersection) ?