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HIST2H2AC and KAT5
Number of citations of the paper that reports this interaction (PMID
10096020
)
46
Data Source:
HPRD
(in vitro)
HIST2H2AC
KAT5
Gene Name
histone cluster 2, H2ac
K(lysine) acetyltransferase 5
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleosome
Nucleus
Extracellular Vesicular Exosome
Swr1 Complex
Nucleus
Nucleoplasm
Transcription Factor Complex
Nucleolus
Cytosol
Piccolo NuA4 Histone Acetyltransferase Complex
NuA4 Histone Acetyltransferase Complex
Perinuclear Region Of Cytoplasm
Molecular Function
Molecular_function
DNA Binding
Protein Heterodimerization Activity
Transcription Coactivator Activity
Histone Acetyltransferase Activity
Protein Binding
Protein Complex Binding
Metal Ion Binding
Androgen Receptor Binding
Repressing Transcription Factor Binding
Biological Process
Biological_process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Double-strand Break Repair
Chromatin Organization
Transcription, DNA-templated
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator
Response To Ionizing Radiation
Viral Process
Histone Acetylation
Androgen Receptor Signaling Pathway
Negative Regulation Of Interleukin-2 Production
Regulation Of Growth
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Cellular Response To Estradiol Stimulus
Positive Regulation Of Protein Acetylation
Pathways
RNA Polymerase I Chain Elongation
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
Mitotic Prophase
Regulatory RNA pathways
RNA Polymerase I Promoter Clearance
Deposition of new CENPA-containing nucleosomes at the centromere
Cellular Senescence
Signaling by Wnt
HATs acetylate histones
M Phase
Amyloids
NoRC negatively regulates rRNA expression
Packaging Of Telomere Ends
Telomere Maintenance
Nucleosome assembly
RNF mutants show enhanced WNT signaling and proliferation
XAV939 inhibits tankyrase, stabilizing AXIN
DNA methylation
Transcriptional regulation by small RNAs
Meiotic recombination
DNA Damage/Telomere Stress Induced Senescence
Chromosome Maintenance
HDACs deacetylate histones
Chromatin organization
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
RNA Polymerase I Transcription
formation of the beta-catenin:TCF transactivating complex
Meiotic synapsis
Epigenetic regulation of gene expression
Senescence-Associated Secretory Phenotype (SASP)
Negative epigenetic regulation of rRNA expression
PRC2 methylates histones and DNA
Cell Cycle, Mitotic
RMTs methylate histone arginines
Chromatin modifying enzymes
Oxidative Stress Induced Senescence
TCF dependent signaling in response to WNT
RNA Polymerase I Promoter Opening
SIRT1 negatively regulates rRNA Expression
Signaling by WNT in cancer
Condensation of Prophase Chromosomes
Chromatin modifying enzymes
Chromatin organization
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
TCF dependent signaling in response to WNT
RNF mutants show enhanced WNT signaling and proliferation
formation of the beta-catenin:TCF transactivating complex
XAV939 inhibits tankyrase, stabilizing AXIN
Signaling by Wnt
Signaling by WNT in cancer
HATs acetylate histones
Drugs
Diseases
GWAS
Chronic kidney disease (
20383146
)
Protein-Protein Interactions
65 interactors:
ANP32A
ATXN7L3
BAP1
BARD1
BAZ1B
BMI1
BRCA1
CDY1
CHFR
COPRS
CRP
CTCFL
CTDP1
DDB2
DNMT3L
EIF2AK2
EP300
GATAD2A
GATAD2B
HAT1
HDAC2
HIST1H2BA
HIST1H3A
HIST1H4A
HIST2H2BE
HIST2H4A
KAT2A
KAT2B
KAT5
KAT7
MSL2
MYSM1
NAP1L4
NCAPH
NCL
NPM1
PARP10
PBRM1
PELP1
PRMT5
PRMT7
RAG1
RBBP4
RCC1
RNF168
RNF2
RNF20
RNF8
SART3
SIRT7
SSRP1
TAF15
TAF1A
TAF1B
TCF20
TSPY1
TSSK6
UBC
UBE2B
UBR2
UIMC1
USP12
USP16
USP22
USP46
136 interactors:
ALOX12
APBB1
APLP1
APLP2
APP
AR
ARIH2
ATM
ATXN1
BARD1
BCL3
BMI1
BRCA1
C1orf174
CBX8
CCDC106
CCDC136
CCNB1
CCT7
CDC42
CDK1
CDK5RAP2
CDKN2A
CREB1
CREBBP
CRELD1
CSTF2
DLEU1
DUSP23
E2F1
EDNRA
EFNA1
EP300
ESR1
ESR2
ETV6
FAM101B
FAM135B
FAM173A
GADD45G
GAPDH
GEMIN7
GET4
GMCL1
GMCL1P1
GOLGA2
GSTO1
H2AFX
H3F3B
HABP4
HAP1
HDAC1
HDAC7
HIST1H3A
HIST1H4A
HIST2H2AC
HIST2H3C
HIST2H4A
HIST3H3
HMBOX1
HNRNPH3
IK
IKZF3
IL9R
KIAA1377
KLF4
KRT40
KRTAP10-3
KRTAP10-9
LMNA
LONRF1
LRIF1
LRP1
LZTS2
MAD2L1BP
MAPRE1
MDFI
MDM2
MEOX2
MTUS2
MYC
MYOD1
NAP1L5
NDUFA4L2
NDUFV2
NFKB1
NINL
NR3C1
ODC1
OGFOD2
PDCD5
PHC2
PIH1D3
PITX2
PLA2G4A
PLEKHA4
PML
POLE2
POLR3F
PPARG
PTPN4
PTPRS
RB1
RCHY1
RELA
RGL2
RRM1
RRM2
SAT1
SNAPIN
SNRPD2
SOX5
SRF
SSX2IP
STAT3
STX11
SYN1
TBX5
TELO2
TMCC2
TNNT1
TP53
TRIB3
TRIM23
TRIM27
TRIM29
TRIM37
TUFT1
UHRF1
USP7
YWHAG
ZBTB14
ZBTB8A
ZEB1
ZNF24
ZNF513
Entrez ID
8338
10524
HPRD ID
09107
03245
Ensembl ID
ENSG00000184260
ENSG00000172977
Uniprot IDs
Q16777
Q92993
PDB IDs
2EKO
2OU2
Enriched GO Terms of Interacting Partners
?
Chromatin Organization
Chromosome Organization
Chromatin Modification
Histone Modification
Organelle Organization
Regulation Of Gene Expression
Nucleobase-containing Compound Metabolic Process
Regulation Of RNA Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Protein Modification Process
Regulation Of RNA Biosynthetic Process
Cellular Nitrogen Compound Metabolic Process
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Histone Ubiquitination
Regulation Of Gene Expression, Epigenetic
Regulation Of Nitrogen Compound Metabolic Process
Nitrogen Compound Metabolic Process
DNA Metabolic Process
Transcription, DNA-templated
RNA Biosynthetic Process
Negative Regulation Of Gene Expression
Cellular Protein Metabolic Process
Gene Expression
Chromatin Remodeling
Regulation Of Metabolic Process
Chromatin Silencing
Cellular Metabolic Process
DNA Packaging
Nucleosome Organization
Protein Metabolic Process
Negative Regulation Of Transcription, DNA-templated
Chromatin Assembly Or Disassembly
Negative Regulation Of Nucleic Acid-templated Transcription
Histone H2A Ubiquitination
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Gene Expression, Epigenetic
Histone Acetylation
Nucleosome Assembly
RNA Metabolic Process
Protein-DNA Complex Assembly
Internal Peptidyl-lysine Acetylation
Negative Regulation Of Cellular Metabolic Process
Peptidyl-lysine Acetylation
Internal Protein Amino Acid Acetylation
Negative Regulation Of Biosynthetic Process
Cell Cycle
Histone Deubiquitination
Chromatin Assembly
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Gene Expression
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Cellular Metabolic Process
Nucleobase-containing Compound Metabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Heterocycle Metabolic Process
Regulation Of Gene Expression
Cellular Nitrogen Compound Metabolic Process
Regulation Of Nitrogen Compound Metabolic Process
Cellular Aromatic Compound Metabolic Process
Nitrogen Compound Metabolic Process
Regulation Of RNA Metabolic Process
Positive Regulation Of Gene Expression
Transcription, DNA-templated
Gene Expression
Regulation Of Transcription, DNA-templated
Positive Regulation Of Cellular Metabolic Process
Regulation Of Nucleic Acid-templated Transcription
RNA Biosynthetic Process
Regulation Of RNA Biosynthetic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
RNA Metabolic Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Developmental Process
Organ Development
Regulation Of Metabolic Process
Positive Regulation Of Transcription, DNA-templated
Multicellular Organismal Development
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Cellular Biosynthetic Process
Chromatin Organization
Positive Regulation Of Metabolic Process
Mitotic Cell Cycle
Chromosome Organization
Anatomical Structure Development
Cellular Macromolecule Biosynthetic Process
System Development
Tissue Development
Cell Cycle
Macromolecule Biosynthetic Process
Regulation Of Cell Proliferation
Cell Death
Apoptotic Process
Death
Organelle Organization
Programmed Cell Death
Biosynthetic Process
Tagcloud
?
accumbens
brn2
decondensed
dmnt1
dnmt3a
erg1
exceptionally
fox3
foxg1
gadd45a
gadd45b
hdac11
homer1
kat2b
kat3a
kat3b
multilineage
multipotent
nef1
neg
neun
neurobiol
neurobiology
neuroplasticity
nfl
nuclei
periodicals
pons
syt1
Tagcloud (Difference)
?
accumbens
brn2
decondensed
dmnt1
dnmt3a
erg1
exceptionally
fox3
foxg1
gadd45a
gadd45b
hdac11
homer1
kat2b
kat3a
kat3b
multilineage
multipotent
nef1
neg
neun
neurobiol
neurobiology
neuroplasticity
nfl
nuclei
periodicals
pons
syt1
Tagcloud (Intersection)
?