RNF2 and CBX7

Number of citations of the paper that reports this interaction (PMID 21282530)
11

Data Source:
BioGRID (pull down, affinity chromatography technology)

		RNF2	CBX7
Gene Name		ring finger protein 2	chromobox homolog 7
Image
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Euchromatin Sex Chromatin Nucleus Nucleoplasm Nuclear Body PcG Protein Complex PRC1 Complex MLL1 Complex	Nuclear Chromatin Heterochromatin Nucleus Nucleoplasm Cytoplasm PcG Protein Complex PRC1 Complex
	Molecular Function	Chromatin Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity RING-like Zinc Finger Domain Binding	Chromatin Binding Single-stranded RNA Binding Protein Binding Methylated Histone Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Cell Cycle Gastrulation With Mouth Forming Second Transcription, DNA-templated Anterior/posterior Axis Specification Histone H2A Monoubiquitination Histone H2A-K119 Monoubiquitination	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Chromatin Modification Sebaceous Gland Development
Pathways		Oxidative Stress Induced Senescence Cellular Senescence
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		54 interactors: ABCB1 AMBRA1 BMI1 CASP3 CASP9 CBX4 CBX6 CBX7 CBX8 HIST1H2AB HIST2H2AA3 HIST2H2AC HIST3H3 KAT8 KMT2A L3MBTL2 MBD1 OTUD6A PCGF1 PCGF2 PCGF3 PCGF5 PCGF6 PGP PHB2 PHC1 PSMC4 RING1 RRM1 RYBP SMURF2 SSX2 TARDBP TFCP2 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2J1 UBE2K UBE2L3 UBE2U UBE2V1 UBE2V2 UBE2W UBE3A USP11 USP19 USP7 WASH1	11 interactors: B3GNT5 BMI1 HIST3H3 PCGF1 PCGF2 PCGF3 PCGF5 PCGF6 RING1 RNF2 SUV39H2
Entrez ID		6045	23492
HPRD ID		07028	12234
Ensembl ID		ENSG00000121481	ENSG00000100307
Uniprot IDs		B3KRH1 Q99496	B0QYP2 O95931
PDB IDs		2H0D 3GS2 3H8H 3IXS 3RPG	2K1B 2L12 2L1B 3GS2
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein Polyubiquitination Protein K48-linked Ubiquitination Cellular Protein Modification Process Histone Ubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Protein K11-linked Ubiquitination Cellular Protein Catabolic Process Chromatin Modification Cellular Macromolecule Catabolic Process Protein Catabolic Process Cellular Metabolic Process Chromatin Organization Cellular Protein Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Transcription, DNA-templated Chromosome Organization Histone Modification RNA Biosynthetic Process Protein Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Proteolysis Protein Monoubiquitination Negative Regulation Of RNA Biosynthetic Process Nitrogen Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Catabolic Process Cellular Macromolecule Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Protein K63-linked Ubiquitination Macromolecule Biosynthetic Process Metabolic Process Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Gene Expression Regulation Of Nucleic Acid-templated Transcription Gene Expression Regulation Of Metabolic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process RNA Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression	Histone Ubiquitination Histone Modification Histone H2A Monoubiquitination Histone H2A Ubiquitination Transcription, DNA-templated RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Chromosome Organization Macromolecule Biosynthetic Process Histone Monoubiquitination Chromatin Modification Chromatin Organization RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Protein Monoubiquitination Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Gene Expression Cellular Nitrogen Compound Metabolic Process Protein Ubiquitination Negative Regulation Of Transcription, DNA-templated Anterior/posterior Pattern Specification Negative Regulation Of Nucleic Acid-templated Transcription Nitrogen Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Protein Modification By Small Protein Conjugation Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Pattern Specification Process Cellular Metabolic Process Organelle Organization Negative Regulation Of Cellular Metabolic Process Cellular Protein Modification Process Peptidyl-lysine Modification Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Histone H2A-K119 Monoubiquitination Cellular Protein Metabolic Process Histone Acetylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Positive Regulation Of Immature T Cell Proliferation In Thymus
Tagcloud ?		aldrich ambra1 arp2 associates autophagy becn1 cul4a ddb1 e3 elusive endosomal impairs impede interactor k48 k63 ligase linkage pik3c3 potentiates scar sorting starvation suppresses ubiquitinate ubiquitination wash wasp wiskott	able acquisition acts carcinomas chemokine contributing counteracts decreases encoding fact hmga1b inducing interacting interferes involves malignant member modulation osteopontin played polycomb progressively relation repressive spp1 suppose take transcriptional whose
Tagcloud (Difference) ?		aldrich ambra1 arp2 associates autophagy becn1 cul4a ddb1 e3 elusive endosomal impairs impede interactor k48 k63 ligase linkage pik3c3 potentiates scar sorting starvation suppresses ubiquitinate ubiquitination wash wasp wiskott	able acquisition acts carcinomas chemokine contributing counteracts decreases encoding fact hmga1b inducing interacting interferes involves malignant member modulation osteopontin played polycomb progressively relation repressive spp1 suppose take transcriptional whose
Tagcloud (Intersection) ?