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HIST2H2AC and CRP
Number of citations of the paper that reports this interaction (PMID
1989977
)
15
Data Source:
BioGRID
(pull down)
HIST2H2AC
CRP
Gene Name
histone cluster 2, H2ac
C-reactive protein, pentraxin-related
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleosome
Nucleus
Extracellular Vesicular Exosome
Extracellular Region
Extracellular Space
Filopodium
Growth Cone
Extracellular Vesicular Exosome
Molecular Function
Molecular_function
DNA Binding
Protein Heterodimerization Activity
Complement Component C1q Binding
Calcium Ion Binding
Protein Binding
Cholesterol Binding
Low-density Lipoprotein Particle Binding
Choline Binding
Protein Homodimerization Activity
Virion Binding
Low-density Lipoprotein Particle Receptor Binding
Biological Process
Biological_process
Response To Hypoxia
Acute-phase Response
Inflammatory Response
Complement Activation, Classical Pathway
Aging
Opsonization
Response To Lead Ion
Positive Regulation Of Gene Expression
Negative Regulation Of Macrophage Derived Foam Cell Differentiation
Negative Regulation Of Lipid Storage
Positive Regulation Of Superoxide Anion Generation
Wound Healing
Response To Ethanol
Negative Regulation Of Vasodilation
Defense Response To Gram-positive Bacterium
Protein Polymerization
Cellular Response To Calcium Ion
Positive Regulation Of Dendrite Development
Regulation Of Interleukin-8 Secretion
Pathways
RNA Polymerase I Chain Elongation
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
Mitotic Prophase
Regulatory RNA pathways
RNA Polymerase I Promoter Clearance
Deposition of new CENPA-containing nucleosomes at the centromere
Cellular Senescence
Signaling by Wnt
HATs acetylate histones
M Phase
Amyloids
NoRC negatively regulates rRNA expression
Packaging Of Telomere Ends
Telomere Maintenance
Nucleosome assembly
RNF mutants show enhanced WNT signaling and proliferation
XAV939 inhibits tankyrase, stabilizing AXIN
DNA methylation
Transcriptional regulation by small RNAs
Meiotic recombination
DNA Damage/Telomere Stress Induced Senescence
Chromosome Maintenance
HDACs deacetylate histones
Chromatin organization
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
RNA Polymerase I Transcription
formation of the beta-catenin:TCF transactivating complex
Meiotic synapsis
Epigenetic regulation of gene expression
Senescence-Associated Secretory Phenotype (SASP)
Negative epigenetic regulation of rRNA expression
PRC2 methylates histones and DNA
Cell Cycle, Mitotic
RMTs methylate histone arginines
Chromatin modifying enzymes
Oxidative Stress Induced Senescence
TCF dependent signaling in response to WNT
RNA Polymerase I Promoter Opening
SIRT1 negatively regulates rRNA Expression
Signaling by WNT in cancer
Condensation of Prophase Chromosomes
Classical antibody-mediated complement activation
Creation of C4 and C2 activators
Complement cascade
Initial triggering of complement
Innate Immune System
Drugs
Phosphocholine
Diseases
GWAS
C-reactive protein (
22492993
19567438
21647738
18439548
18439552
21196492
21300955
22939635
)
Inflammatory biomarkers (
22291609
)
Lung cancer (
18385676
)
Metabolic traits (
19060910
)
Protein quantitative trait loci (
18464913
)
Select biomarker traits (
17903293
)
Protein-Protein Interactions
65 interactors:
ANP32A
ATXN7L3
BAP1
BARD1
BAZ1B
BMI1
BRCA1
CDY1
CHFR
COPRS
CRP
CTCFL
CTDP1
DDB2
DNMT3L
EIF2AK2
EP300
GATAD2A
GATAD2B
HAT1
HDAC2
HIST1H2BA
HIST1H3A
HIST1H4A
HIST2H2BE
HIST2H4A
KAT2A
KAT2B
KAT5
KAT7
MSL2
MYSM1
NAP1L4
NCAPH
NCL
NPM1
PARP10
PBRM1
PELP1
PRMT5
PRMT7
RAG1
RBBP4
RCC1
RNF168
RNF2
RNF20
RNF8
SART3
SIRT7
SSRP1
TAF15
TAF1A
TAF1B
TCF20
TSPY1
TSSK6
UBC
UBE2B
UBR2
UIMC1
USP12
USP16
USP22
USP46
20 interactors:
APCS
C1QA
CFH
DGCR14
FCGR1A
FCGR2A
FCGR2B
FN1
GLUD1
GMPPA
GP6
HIST1H1A
HIST1H2AL
HIST2H2AC
LAMC3
LEP
MAPK1
MAPK3
RPL13A
SNRNP70
Entrez ID
8338
1401
HPRD ID
09107
00422
Ensembl ID
ENSG00000184260
ENSG00000132693
Uniprot IDs
Q16777
P02741
PDB IDs
1B09
1CRV
1GNH
1LJ7
3L2Y
3PVN
3PVO
Enriched GO Terms of Interacting Partners
?
Chromatin Organization
Chromosome Organization
Chromatin Modification
Histone Modification
Organelle Organization
Regulation Of Gene Expression
Nucleobase-containing Compound Metabolic Process
Regulation Of RNA Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Protein Modification Process
Regulation Of RNA Biosynthetic Process
Cellular Nitrogen Compound Metabolic Process
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Histone Ubiquitination
Regulation Of Gene Expression, Epigenetic
Regulation Of Nitrogen Compound Metabolic Process
Nitrogen Compound Metabolic Process
DNA Metabolic Process
Transcription, DNA-templated
RNA Biosynthetic Process
Negative Regulation Of Gene Expression
Cellular Protein Metabolic Process
Gene Expression
Chromatin Remodeling
Regulation Of Metabolic Process
Chromatin Silencing
Cellular Metabolic Process
DNA Packaging
Nucleosome Organization
Protein Metabolic Process
Negative Regulation Of Transcription, DNA-templated
Chromatin Assembly Or Disassembly
Negative Regulation Of Nucleic Acid-templated Transcription
Histone H2A Ubiquitination
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Gene Expression, Epigenetic
Histone Acetylation
Nucleosome Assembly
RNA Metabolic Process
Protein-DNA Complex Assembly
Internal Peptidyl-lysine Acetylation
Negative Regulation Of Cellular Metabolic Process
Peptidyl-lysine Acetylation
Internal Protein Amino Acid Acetylation
Negative Regulation Of Biosynthetic Process
Cell Cycle
Histone Deubiquitination
Chromatin Assembly
Immune System Process
Innate Immune Response
Immune Response
Regulation Of Immune System Process
Defense Response
Regulation Of Golgi Inheritance
Regulation Of Immune Response
Positive Regulation Of Immune System Process
Caveolin-mediated Endocytosis
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Fc-gamma Receptor Signaling Pathway
Fc Receptor Mediated Stimulatory Signaling Pathway
Positive Regulation Of Immune Response
JAK-STAT Cascade
Regulation Of Golgi Organization
Platelet Activation
Response To Stress
Regulation Of Early Endosome To Late Endosome Transport
Phagocytosis
Fc Receptor Signaling Pathway
Immune Response-activating Cell Surface Receptor Signaling Pathway
Cellular Response To Cytokine Stimulus
JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway
Growth Hormone Receptor Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Cellular Response To Growth Hormone Stimulus
Response To Cytokine
Response To Epidermal Growth Factor
Regulation Of Cellular Response To Heat
Blood Coagulation
Hemostasis
Lipopolysaccharide-mediated Signaling Pathway
Acute-phase Response
Immune Response-regulating Signaling Pathway
Response To Growth Hormone
Response To Exogenous DsRNA
Leukocyte Migration
Negative Regulation Of Formation Of Translation Preinitiation Complex
Positive Regulation Of Luteinizing Hormone Secretion
Negative Regulation Of Glutamine Transport
Negative Regulation Of Apolipoprotein Binding
Cellular Response To L-ascorbic Acid
Toll-like Receptor 5 Signaling Pathway
Viral Process
Toll-like Receptor 10 Signaling Pathway
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor 2 Signaling Pathway
Regulation Of Body Fluid Levels
Toll-like Receptor 9 Signaling Pathway
Tagcloud
?
antibiotic
appropriate
children
chosen
circulating
cutoff
detectable
febrile
fell
fever
greatly
helpful
il
involving
lasting
necrosis
none
pediatric
pg
pneumonia
probable
rather
remained
sequential
syndrome
tnf
tool
uti
viral
Tagcloud (Difference)
?
antibiotic
appropriate
children
chosen
circulating
cutoff
detectable
febrile
fell
fever
greatly
helpful
il
involving
lasting
necrosis
none
pediatric
pg
pneumonia
probable
rather
remained
sequential
syndrome
tnf
tool
uti
viral
Tagcloud (Intersection)
?