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HIST2H2AC and PBRM1
Number of citations of the paper that reports this interaction (PMID
20368734
)
7
Data Source:
BioGRID
(unspecified method)
HIST2H2AC
PBRM1
Gene Name
histone cluster 2, H2ac
polybromo 1
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleosome
Nucleus
Extracellular Vesicular Exosome
Nuclear Chromosome
Kinetochore
Molecular Function
Molecular_function
DNA Binding
Protein Heterodimerization Activity
DNA Binding
Chromatin Binding
Protein Binding
Biological Process
Biological_process
Placenta Development
Chromatin Remodeling
Transcription, DNA-templated
Regulation Of Transcription, DNA-templated
Mitotic Nuclear Division
Heart Development
Negative Regulation Of Cell Proliferation
Pathways
RNA Polymerase I Chain Elongation
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
Mitotic Prophase
Regulatory RNA pathways
RNA Polymerase I Promoter Clearance
Deposition of new CENPA-containing nucleosomes at the centromere
Cellular Senescence
Signaling by Wnt
HATs acetylate histones
M Phase
Amyloids
NoRC negatively regulates rRNA expression
Packaging Of Telomere Ends
Telomere Maintenance
Nucleosome assembly
RNF mutants show enhanced WNT signaling and proliferation
XAV939 inhibits tankyrase, stabilizing AXIN
DNA methylation
Transcriptional regulation by small RNAs
Meiotic recombination
DNA Damage/Telomere Stress Induced Senescence
Chromosome Maintenance
HDACs deacetylate histones
Chromatin organization
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
RNA Polymerase I Transcription
formation of the beta-catenin:TCF transactivating complex
Meiotic synapsis
Epigenetic regulation of gene expression
Senescence-Associated Secretory Phenotype (SASP)
Negative epigenetic regulation of rRNA expression
PRC2 methylates histones and DNA
Cell Cycle, Mitotic
RMTs methylate histone arginines
Chromatin modifying enzymes
Oxidative Stress Induced Senescence
TCF dependent signaling in response to WNT
RNA Polymerase I Promoter Opening
SIRT1 negatively regulates rRNA Expression
Signaling by WNT in cancer
Condensation of Prophase Chromosomes
Chromatin modifying enzymes
Chromatin organization
RMTs methylate histone arginines
Drugs
Diseases
GWAS
Bipolar disorder (
21926972
)
Bipolar disorder (mood-incongruent) (
23092984
)
Major mood disorders (
20081856
)
Protein-Protein Interactions
65 interactors:
ANP32A
ATXN7L3
BAP1
BARD1
BAZ1B
BMI1
BRCA1
CDY1
CHFR
COPRS
CRP
CTCFL
CTDP1
DDB2
DNMT3L
EIF2AK2
EP300
GATAD2A
GATAD2B
HAT1
HDAC2
HIST1H2BA
HIST1H3A
HIST1H4A
HIST2H2BE
HIST2H4A
KAT2A
KAT2B
KAT5
KAT7
MSL2
MYSM1
NAP1L4
NCAPH
NCL
NPM1
PARP10
PBRM1
PELP1
PRMT5
PRMT7
RAG1
RBBP4
RCC1
RNF168
RNF2
RNF20
RNF8
SART3
SIRT7
SSRP1
TAF15
TAF1A
TAF1B
TCF20
TSPY1
TSSK6
UBC
UBE2B
UBR2
UIMC1
USP12
USP16
USP22
USP46
9 interactors:
APP
HIST1H3A
HIST1H4A
HIST2H2AC
HIST2H2BE
PTS
SMARCA4
ZDHHC17
ZNF512B
Entrez ID
8338
55193
HPRD ID
09107
07302
Ensembl ID
ENSG00000184260
ENSG00000163939
Uniprot IDs
Q16777
Q86U86
PDB IDs
2KTB
3G0J
3HMF
3IU5
3IU6
3K2J
3LJW
3MB4
3TLP
Enriched GO Terms of Interacting Partners
?
Chromatin Organization
Chromosome Organization
Chromatin Modification
Histone Modification
Organelle Organization
Regulation Of Gene Expression
Nucleobase-containing Compound Metabolic Process
Regulation Of RNA Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Protein Modification Process
Regulation Of RNA Biosynthetic Process
Cellular Nitrogen Compound Metabolic Process
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Histone Ubiquitination
Regulation Of Gene Expression, Epigenetic
Regulation Of Nitrogen Compound Metabolic Process
Nitrogen Compound Metabolic Process
DNA Metabolic Process
Transcription, DNA-templated
RNA Biosynthetic Process
Negative Regulation Of Gene Expression
Cellular Protein Metabolic Process
Gene Expression
Chromatin Remodeling
Regulation Of Metabolic Process
Chromatin Silencing
Cellular Metabolic Process
DNA Packaging
Nucleosome Organization
Protein Metabolic Process
Negative Regulation Of Transcription, DNA-templated
Chromatin Assembly Or Disassembly
Negative Regulation Of Nucleic Acid-templated Transcription
Histone H2A Ubiquitination
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Gene Expression, Epigenetic
Histone Acetylation
Nucleosome Assembly
RNA Metabolic Process
Protein-DNA Complex Assembly
Internal Peptidyl-lysine Acetylation
Negative Regulation Of Cellular Metabolic Process
Peptidyl-lysine Acetylation
Internal Protein Amino Acid Acetylation
Negative Regulation Of Biosynthetic Process
Cell Cycle
Histone Deubiquitination
Chromatin Assembly
DNA Methylation On Cytosine
Nucleosome Organization
Chromatin Assembly Or Disassembly
Chromatin Silencing
DNA Methylation
Negative Regulation Of Gene Expression, Epigenetic
DNA Modification
DNA Replication-dependent Nucleosome Assembly
Gene Silencing
Nucleosome Assembly
Chromatin Assembly
Chromatin Silencing At RDNA
Protein-DNA Complex Assembly
DNA Packaging
Regulation Of Gene Expression, Epigenetic
Chromatin Organization
DNA Conformation Change
ATP-dependent Chromatin Remodeling
Chromosome Organization
Methylation
Negative Regulation Of Transcription From RNA Polymerase II Promoter During Mitosis
Synaptic Growth At Neuromuscular Junction
Collateral Sprouting In Absence Of Injury
Histone H4-K20 Demethylation
Cellular Macromolecular Complex Assembly
DNA Methylation On Cytosine Within A CG Sequence
Negative Regulation Of Megakaryocyte Differentiation
Collateral Sprouting
Axon Midline Choice Point Recognition
Chromatin Remodeling
Negative Regulation Of Cell Differentiation
Smooth Endoplasmic Reticulum Calcium Ion Homeostasis
Definitive Erythrocyte Differentiation
Aortic Smooth Muscle Cell Differentiation
Axon Choice Point Recognition
Tetrahydrobiopterin Biosynthetic Process
Glial Cell Fate Determination
Methylation-dependent Chromatin Silencing
Regulation Of Mitotic Cell Cycle Phase Transition
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Regulation Of Cell Cycle Phase Transition
Negative Regulation Of Hematopoietic Progenitor Cell Differentiation
Neuron Remodeling
Cellular Component Assembly
Positive Regulation By Host Of Viral Transcription
Cellular Nitrogen Compound Metabolic Process
Regulation Of Binding
Central Nervous System Development
Developmental Growth
Tagcloud
?
1000x
abstracted
arid1a
bap1
cca
cdkn2a
cholangiocarcinoma
entities
extrahepatic
fbxw7
fgfr
gas
hiseq
hotspot
idh1
illumina
indolent
intrahepatic
introns
kras
mcl1
ngs
pgm
presentations
radiologic
sequencer
smad4
targetable
worse
Tagcloud (Difference)
?
1000x
abstracted
arid1a
bap1
cca
cdkn2a
cholangiocarcinoma
entities
extrahepatic
fbxw7
fgfr
gas
hiseq
hotspot
idh1
illumina
indolent
intrahepatic
introns
kras
mcl1
ngs
pgm
presentations
radiologic
sequencer
smad4
targetable
worse
Tagcloud (Intersection)
?