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HIST2H2AC and KAT2A
Number of citations of the paper that reports this interaction (PMID
8684459
)
381
Data Source:
BioGRID
(enzymatic study, enzymatic study)
HIST2H2AC
KAT2A
Gene Name
histone cluster 2, H2ac
K(lysine) acetyltransferase 2A
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleosome
Nucleus
Extracellular Vesicular Exosome
Extracellular Space
Nucleoplasm
Ada2/Gcn5/Ada3 Transcription Activator Complex
STAGA Complex
Transcription Factor TFTC Complex
Mitotic Spindle
Molecular Function
Molecular_function
DNA Binding
Protein Heterodimerization Activity
Chromatin Binding
Transcription Coactivator Activity
Histone Acetyltransferase Activity
Protein Binding
H3 Histone Acetyltransferase Activity
Histone Deacetylase Binding
Histone Acetyltransferase Activity (H4-K12 Specific)
Biological Process
Biological_process
In Utero Embryonic Development
Somitogenesis
Neural Tube Closure
Chromatin Organization
Chromatin Remodeling
Regulation Of Transcription From RNA Polymerase II Promoter
Transcription From RNA Polymerase II Promoter
Cell Proliferation
Viral Process
Histone Deubiquitination
Telencephalon Development
Metencephalon Development
Midbrain Development
Regulation Of Protein Stability
Multicellular Organism Growth
Positive Regulation Of Gluconeogenesis By Positive Regulation Of Transcription From RNA Polymerase II Promoter
Histone H3 Acetylation
Histone H4-K12 Acetylation
Histone H3-K14 Acetylation
Pathways
RNA Polymerase I Chain Elongation
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
Mitotic Prophase
Regulatory RNA pathways
RNA Polymerase I Promoter Clearance
Deposition of new CENPA-containing nucleosomes at the centromere
Cellular Senescence
Signaling by Wnt
HATs acetylate histones
M Phase
Amyloids
NoRC negatively regulates rRNA expression
Packaging Of Telomere Ends
Telomere Maintenance
Nucleosome assembly
RNF mutants show enhanced WNT signaling and proliferation
XAV939 inhibits tankyrase, stabilizing AXIN
DNA methylation
Transcriptional regulation by small RNAs
Meiotic recombination
DNA Damage/Telomere Stress Induced Senescence
Chromosome Maintenance
HDACs deacetylate histones
Chromatin organization
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
RNA Polymerase I Transcription
formation of the beta-catenin:TCF transactivating complex
Meiotic synapsis
Epigenetic regulation of gene expression
Senescence-Associated Secretory Phenotype (SASP)
Negative epigenetic regulation of rRNA expression
PRC2 methylates histones and DNA
Cell Cycle, Mitotic
RMTs methylate histone arginines
Chromatin modifying enzymes
Oxidative Stress Induced Senescence
TCF dependent signaling in response to WNT
RNA Polymerase I Promoter Opening
SIRT1 negatively regulates rRNA Expression
Signaling by WNT in cancer
Condensation of Prophase Chromosomes
Signaling by NOTCH1 HD Domain Mutants in Cancer
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
RNA Polymerase I Transcription Initiation
RNA Polymerase I Promoter Clearance
HATs acetylate histones
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
Generic Transcription Pathway
Pre-NOTCH Transcription and Translation
Signaling by NOTCH1
Pre-NOTCH Expression and Processing
Signaling by NOTCH1 in Cancer
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
FBXW7 Mutants and NOTCH1 in Cancer
Chromatin organization
RNA Polymerase I Transcription
Signaling by NOTCH
Notch-HLH transcription pathway
NOTCH1 Intracellular Domain Regulates Transcription
Chromatin modifying enzymes
Signaling by NOTCH1 PEST Domain Mutants in Cancer
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Drugs
Diseases
GWAS
Protein-Protein Interactions
65 interactors:
ANP32A
ATXN7L3
BAP1
BARD1
BAZ1B
BMI1
BRCA1
CDY1
CHFR
COPRS
CRP
CTCFL
CTDP1
DDB2
DNMT3L
EIF2AK2
EP300
GATAD2A
GATAD2B
HAT1
HDAC2
HIST1H2BA
HIST1H3A
HIST1H4A
HIST2H2BE
HIST2H4A
KAT2A
KAT2B
KAT5
KAT7
MSL2
MYSM1
NAP1L4
NCAPH
NCL
NPM1
PARP10
PBRM1
PELP1
PRMT5
PRMT7
RAG1
RBBP4
RCC1
RNF168
RNF2
RNF20
RNF8
SART3
SIRT7
SSRP1
TAF15
TAF1A
TAF1B
TCF20
TSPY1
TSSK6
UBC
UBE2B
UBR2
UIMC1
USP12
USP16
USP22
USP46
45 interactors:
ATXN7
BATF2
BRCA1
CDK2
CEBPB
COMMD1
CREBBP
CRX
CTNNB1
CUL2
DTL
EID1
EP300
GATA2
HIST1H1B
HIST1H3A
HIST1H4A
HIST2H2AC
HIST2H2BE
HIST2H3C
HIST2H4A
HIST3H3
HIST4H4
HSD11B2
IRF1
IRF2
IRF7
MYB
MYC
NOTCH1
PBX1
PPARG
PRKDC
PYGO2
RBPJ
RELA
SIRT2
SUMO1
TACC1
TACC2
TACC3
TADA2A
TCF3
TRRAP
XRCC6
Entrez ID
8338
2648
HPRD ID
09107
03807
Ensembl ID
ENSG00000184260
ENSG00000108773
Uniprot IDs
Q16777
Q92830
PDB IDs
1F68
1Z4R
3D7C
Enriched GO Terms of Interacting Partners
?
Chromatin Organization
Chromosome Organization
Chromatin Modification
Histone Modification
Organelle Organization
Regulation Of Gene Expression
Nucleobase-containing Compound Metabolic Process
Regulation Of RNA Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Protein Modification Process
Regulation Of RNA Biosynthetic Process
Cellular Nitrogen Compound Metabolic Process
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Histone Ubiquitination
Regulation Of Gene Expression, Epigenetic
Regulation Of Nitrogen Compound Metabolic Process
Nitrogen Compound Metabolic Process
DNA Metabolic Process
Transcription, DNA-templated
RNA Biosynthetic Process
Negative Regulation Of Gene Expression
Cellular Protein Metabolic Process
Gene Expression
Chromatin Remodeling
Regulation Of Metabolic Process
Chromatin Silencing
Cellular Metabolic Process
DNA Packaging
Nucleosome Organization
Protein Metabolic Process
Negative Regulation Of Transcription, DNA-templated
Chromatin Assembly Or Disassembly
Negative Regulation Of Nucleic Acid-templated Transcription
Histone H2A Ubiquitination
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Gene Expression, Epigenetic
Histone Acetylation
Nucleosome Assembly
RNA Metabolic Process
Protein-DNA Complex Assembly
Internal Peptidyl-lysine Acetylation
Negative Regulation Of Cellular Metabolic Process
Peptidyl-lysine Acetylation
Internal Protein Amino Acid Acetylation
Negative Regulation Of Biosynthetic Process
Cell Cycle
Histone Deubiquitination
Chromatin Assembly
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Gene Expression
Negative Regulation Of Biosynthetic Process
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Negative Regulation Of Cellular Metabolic Process
Regulation Of RNA Metabolic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Transcription, DNA-templated
Regulation Of Gene Expression
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Gene Expression
Positive Regulation Of Cellular Biosynthetic Process
Cellular Nitrogen Compound Metabolic Process
Chromosome Organization
Nitrogen Compound Metabolic Process
Positive Regulation Of Cellular Metabolic Process
Response To Stress
Gene Expression
Cell Cycle
Chromatin Organization
Transcription, DNA-templated
Negative Regulation Of Transcription From RNA Polymerase II Promoter
RNA Biosynthetic Process
Chromatin Silencing At RDNA
Regulation Of Cell Differentiation
Transcription From RNA Polymerase II Promoter
Positive Regulation Of Type I Interferon Production
Organelle Organization
Regulation Of Metabolic Process
Immune System Process
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Positive Regulation Of Metabolic Process
Regulation Of Type I Interferon Production
Negative Regulation Of Cell Differentiation
Chromatin Modification
DNA Methylation On Cytosine
Response To Abiotic Stimulus
Regulation Of Histone Modification
Chromatin Silencing
Regulation Of Chromosome Organization
Tagcloud
?
acetyltransferase
antiviral
correlates
cytoplasm
dispensable
enriched
establish
gcn5
h3k9
h3k9ac
hat
ifn
ifnb
immune
immunity
inhibiting
innate
instead
kat2b
pcaf
production
redundancy
regulators
repress
surprisingly
tbk1
triggers
turn
vast
Tagcloud (Difference)
?
acetyltransferase
antiviral
correlates
cytoplasm
dispensable
enriched
establish
gcn5
h3k9
h3k9ac
hat
ifn
ifnb
immune
immunity
inhibiting
innate
instead
kat2b
pcaf
production
redundancy
regulators
repress
surprisingly
tbk1
triggers
turn
vast
Tagcloud (Intersection)
?