H2AC20 and CSTF1

Number of citations of the paper that reports this interaction (PubMedID 29180510)
66

Data Source:
BioGRID (pull down)

		H2AC20	CSTF1
Description		H2A clustered histone 20	cleavage stimulation factor subunit 1
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GO Annotations	Cellular Component	Nucleosome Nucleus Chromosome Extracellular Exosome	Nucleus Nucleoplasm MRNA Cleavage Stimulating Factor Complex
	Molecular Function	DNA Binding Structural Constituent Of Chromatin Protein Heterodimerization Activity	RNA Binding Protein Binding
	Biological Process	Heterochromatin Formation	MRNA Processing MRNA 3'-end Processing
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence HDACs deacetylate histones HATs acetylate histones HATs acetylate histones RMTs methylate histone arginines SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 UCH proteinases Ub-specific processing proteases Metalloprotease DUBs Deposition of new CENPA-containing nucleosomes at the centromere Assembly of the ORC complex at the origin of replication RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Inhibition of DNA recombination at telomere Defective pyroptosis Negative Regulation of CDH1 Gene Transcription Amyloid fiber formation Chromatin modifications during the maternal to zygotic transition (MZT) MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Regulation of PD-L1(CD274) transcription	mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs
Drugs
Diseases
GWAS			Cognitive decline (age-related) ( 28078323)
Interacting Genes		72 interacting genes: ANP32A APP ATXN7L3 BAP1 BARD1 BMI1 BRCA1 CDY1 CEBPA CRP CSTF1 CTCFL DDB2 DNMT3L EIF2AK2 EP300 ESR1 FBL GATAD2A GATAD2B H2BC1 H4C14 HAT1 HDAC2 KAT2A KAT2B KAT5 KAT7 MSL2 MYSM1 NAA40 NAP1L4 NCAPH NCL NPM1 PARP10 PBRM1 PELP1 POT1 PRMT5 PRMT7 RAG1 RBBP4 RCC1 RNF168 RNF2 RNF20 RNF8 SART3 SIRT7 STK38 TAF15 TAF1A TAF1B TCF20 TRIM37 TSPY1 TSSK6 UBC UBE2B UBE2H UBR2 UIMC1 USP10 USP12 USP16 USP2 USP22 USP46 USP51 USP7 USP8	12 interacting genes: BARD1 BRCA1 CSTF3 H2AC20 MIR140 MIR206 MIR92A2 MIRLET7A3 MIRLET7I POLR2A VCP WEE2-AS1
Entrez ID		8338	1477
HPRD ID		09107	02653
Ensembl ID		ENSG00000184260	ENSG00000101138
Uniprot IDs		Q16777	Q05048
PDB IDs		6Y5E 7U0G 7U0I 7U0J 8DK5 8EVG 8EVH 8EVI 8EVJ 8SPS 8SPU 8SYP	6B3X
Enriched GO Terms of Interacting Partners?		Chromatin Organization Chromatin Remodeling Nucleus Histone Binding Nucleoplasm Epigenetic Regulation Of Gene Expression Chromatin Binding Chromosome Protein Modification Process Macromolecule Metabolic Process Post-translational Protein Modification Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Protein Metabolic Process Regulation Of RNA Metabolic Process Regulation Of DNA Repair Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Cellular Response To Stress Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Regulation Of Cell Cycle Regulation Of Primary Metabolic Process Regulation Of Gene Expression Histone H4 Acetyltransferase Activity Cysteine-type Deubiquitinase Activity Negative Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Histone H2A Deubiquitinase Activity Protein Deubiquitination Regulation Of DNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Histone Acetyltransferase Activity DNA Damage Response Protein Modification By Small Protein Removal Negative Regulation Of Biosynthetic Process Transferase Activity Nucleic Acid Metabolic Process DNA Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Cysteine-type Peptidase Activity Protein-containing Complex Positive Regulation Of DNA-templated Transcription	RISC Complex MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex BRCA1-B Complex Negative Regulation Of Gene Expression Nuclear Ubiquitin Ligase Complex BRCA1-C Complex MRNA Base-pairing Post-transcriptional Repressor Activity BRCA1-A Complex Ubiquitin-modified Histone Reader Activity Post-transcriptional Regulation Of Gene Expression DNA Strand Resection Involved In Replication Fork Processing Negative Regulation Of Macromolecule Metabolic Process MRNA 3'-UTR Binding Regulation Of DNA Damage Checkpoint Negative Regulation Of Metabolic Process Protein K6-linked Ubiquitination Negative Regulation Of Macromolecule Biosynthetic Process Postreplication Repair Homologous Recombination Negative Regulation Of Biosynthetic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Macromolecule Metabolic Process Positive Regulation Of Catabolic Process Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Interleukin-6 Production Mitotic G2/M Transition Checkpoint Negative Regulation Of MRNA 3'-end Processing Flavin Adenine Dinucleotide Catabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process Negative Regulation Of Lipid Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Ubiquitin Protein Ligase Binding Negative Regulation Of Cell Cycle G2/M Phase Transition Cellular Response To Ionizing Radiation Regulation Of MRNA Metabolic Process MRNA Cleavage Stimulating Factor Complex VCP-NSFL1C Complex Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Positive Regulation Of Protein K63-linked Deubiquitination Positive Regulation Of Muscle Cell Differentiation Negative Regulation Of Intracellular Signal Transduction RNA-directed RNA Polymerase Activity
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