RNF2 and UBE2E3

Number of citations of the paper that reports this interaction (PMID 19549727)
40

Data Source:
BioGRID (two hybrid)

		RNF2	UBE2E3
Gene Name		ring finger protein 2	ubiquitin-conjugating enzyme E2E 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Euchromatin Sex Chromatin Nucleus Nucleoplasm Nuclear Body PcG Protein Complex PRC1 Complex MLL1 Complex	Nucleus Cytoplasm
	Molecular Function	Chromatin Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity RING-like Zinc Finger Domain Binding	Ubiquitin-protein Transferase Activity ATP Binding Ligase Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Cell Cycle Gastrulation With Mouth Forming Second Transcription, DNA-templated Anterior/posterior Axis Specification Histone H2A Monoubiquitination Histone H2A-K119 Monoubiquitination	Regulation Of Growth Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination
Pathways		Oxidative Stress Induced Senescence Cellular Senescence	Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)	Celiac disease ( 20190752) Obesity ( 21552555)
Protein-Protein Interactions		54 interactors: ABCB1 AMBRA1 BMI1 CASP3 CASP9 CBX4 CBX6 CBX7 CBX8 HIST1H2AB HIST2H2AA3 HIST2H2AC HIST3H3 KAT8 KMT2A L3MBTL2 MBD1 OTUD6A PCGF1 PCGF2 PCGF3 PCGF5 PCGF6 PGP PHB2 PHC1 PSMC4 RING1 RRM1 RYBP SMURF2 SSX2 TARDBP TFCP2 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2J1 UBE2K UBE2L3 UBE2U UBE2V1 UBE2V2 UBE2W UBE3A USP11 USP19 USP7 WASH1	75 interactors: ACVR1 ARID3A ARIH2 ATXN1 BARD1 BRCA1 CADPS2 CHFR CHUK CNOT4 CUL1 CUL3 CUL4A DTX3 DTX3L DZIP3 HERC4 HTT IPO11 ITCH KLHL42 MARCH5 MDM2 MID1 MID2 MKRN3 MUL1 NEDD4L NFKBIA RBX1 RCBTB1 RCBTB2 RFWD3 RING1 RMND5B RNF10 RNF11 RNF111 RNF114 RNF115 RNF13 RNF130 RNF14 RNF150 RNF165 RNF166 RNF167 RNF181 RNF185 RNF2 RNF25 RNF4 RNF43 RNF5 RNF8 SAE1 SIAH1 SPOP STUB1 TGFBR1 TRIM2 TRIM27 TRIM32 TRIM37 TRIM38 TRIM39 TRIM45 TRIM50 UBA1 UBC UBOX5 UFM1 WWP2 ZNRF1 ZNRF4
Entrez ID		6045	10477
HPRD ID		07028	05000
Ensembl ID		ENSG00000121481	ENSG00000170035
Uniprot IDs		B3KRH1 Q99496	Q969T4
PDB IDs		2H0D 3GS2 3H8H 3IXS 3RPG
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein Polyubiquitination Protein K48-linked Ubiquitination Cellular Protein Modification Process Histone Ubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Protein K11-linked Ubiquitination Cellular Protein Catabolic Process Chromatin Modification Cellular Macromolecule Catabolic Process Protein Catabolic Process Cellular Metabolic Process Chromatin Organization Cellular Protein Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Transcription, DNA-templated Chromosome Organization Histone Modification RNA Biosynthetic Process Protein Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Proteolysis Protein Monoubiquitination Negative Regulation Of RNA Biosynthetic Process Nitrogen Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Catabolic Process Cellular Macromolecule Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Protein K63-linked Ubiquitination Macromolecule Biosynthetic Process Metabolic Process Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Gene Expression Regulation Of Nucleic Acid-templated Transcription Gene Expression Regulation Of Metabolic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process RNA Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression See more	Protein Modification By Small Protein Conjugation Protein Ubiquitination Cellular Protein Modification Process Protein Polyubiquitination Cellular Protein Metabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Metabolic Process Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Protein Autoubiquitination Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Cellular Metabolic Process Catabolic Process Protein K63-linked Ubiquitination Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein K48-linked Ubiquitination Protein Monoubiquitination Metabolic Process Regulation Of Signal Transduction Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Cell Cycle Regulation Of Cell Cycle Negative Regulation Of Signal Transduction Regulation Of Signaling Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Protein Catabolic Process Negative Regulation Of Signaling Histone Ubiquitination Histone H2A Ubiquitination Regulation Of Protein Catabolic Process Cell Cycle Histone Monoubiquitination Response To Stress Apoptotic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Type I Interferon Production Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Programmed Cell Death Cellular Response To Stress Protein K6-linked Ubiquitination Cell Cycle Process Regulation Of Gene Expression Positive Regulation Of Metabolic Process Mitotic Cell Cycle See more
Tagcloud ?		aldrich ambra1 arp2 associates autophagy becn1 cul4a ddb1 e3 elusive endosomal impairs impede interactor k48 k63 ligase linkage pik3c3 potentiates scar sorting starvation suppresses ubiquitinate ubiquitination wash wasp wiskott	conjugating cytoprotective degraded extracting govern homeostasis imp import importin keap1 locales localizes mitochondria nrf2 outer p45 partitioning perinuclear prematurely relocalizes repressive restore restrict restricting subcellular tightly transcriptionally unresolved
Tagcloud (Difference) ?		aldrich ambra1 arp2 associates autophagy becn1 cul4a ddb1 e3 elusive endosomal impairs impede interactor k48 k63 ligase linkage pik3c3 potentiates scar sorting starvation suppresses ubiquitinate ubiquitination wash wasp wiskott	conjugating cytoprotective degraded extracting govern homeostasis imp import importin keap1 locales localizes mitochondria nrf2 outer p45 partitioning perinuclear prematurely relocalizes repressive restore restrict restricting subcellular tightly transcriptionally unresolved
Tagcloud (Intersection) ?