HIST2H2AC and NCAPH

Number of citations of the paper that reports this interaction (PMID 21633354)
36

Data Source:
BioGRID (pull down, affinity chromatography technology)

		HIST2H2AC	NCAPH
Gene Name		histone cluster 2, H2ac	non-SMC condensin I complex, subunit H
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleosome Nucleus Extracellular Vesicular Exosome	Condensin Complex Nucleus Cytoplasm Cytosol Membrane
	Molecular Function	Molecular_function DNA Binding Protein Heterodimerization Activity	Protein Binding
	Biological Process	Biological_process	Mitotic Cell Cycle Mitotic Chromosome Condensation Cell Division
Pathways		RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mitotic Prophase Regulatory RNA pathways RNA Polymerase I Promoter Clearance Deposition of new CENPA-containing nucleosomes at the centromere Cellular Senescence Signaling by Wnt HATs acetylate histones M Phase Amyloids NoRC negatively regulates rRNA expression Packaging Of Telomere Ends Telomere Maintenance Nucleosome assembly RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN DNA methylation Transcriptional regulation by small RNAs Meiotic recombination DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance HDACs deacetylate histones Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling RNA Polymerase I Transcription formation of the beta-catenin:TCF transactivating complex Meiotic synapsis Epigenetic regulation of gene expression Senescence-Associated Secretory Phenotype (SASP) Negative epigenetic regulation of rRNA expression PRC2 methylates histones and DNA Cell Cycle, Mitotic RMTs methylate histone arginines Chromatin modifying enzymes Oxidative Stress Induced Senescence TCF dependent signaling in response to WNT RNA Polymerase I Promoter Opening SIRT1 negatively regulates rRNA Expression Signaling by WNT in cancer Condensation of Prophase Chromosomes	Mitotic Prometaphase Cell Cycle, Mitotic M Phase Condensation of Prometaphase Chromosomes
Drugs
Diseases
GWAS
Protein-Protein Interactions		65 interactors: ANP32A ATXN7L3 BAP1 BARD1 BAZ1B BMI1 BRCA1 CDY1 CHFR COPRS CRP CTCFL CTDP1 DDB2 DNMT3L EIF2AK2 EP300 GATAD2A GATAD2B HAT1 HDAC2 HIST1H2BA HIST1H3A HIST1H4A HIST2H2BE HIST2H4A KAT2A KAT2B KAT5 KAT7 MSL2 MYSM1 NAP1L4 NCAPH NCL NPM1 PARP10 PBRM1 PELP1 PRMT5 PRMT7 RAG1 RBBP4 RCC1 RNF168 RNF2 RNF20 RNF8 SART3 SIRT7 SSRP1 TAF15 TAF1A TAF1B TCF20 TSPY1 TSSK6 UBC UBE2B UBR2 UIMC1 USP12 USP16 USP22 USP46	6 interactors: AURKB CAPG CDK1 H2AFZ HIST2H2AC NCAPD2
Entrez ID		8338	23397
HPRD ID		09107	03820
Ensembl ID		ENSG00000184260	ENSG00000121152
Uniprot IDs		Q16777	B4DRG7 B4E189 Q15003
PDB IDs
Enriched GO Terms of Interacting Partners?		Chromatin Organization Chromosome Organization Chromatin Modification Histone Modification Organelle Organization Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Protein Modification Process Regulation Of RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Histone Ubiquitination Regulation Of Gene Expression, Epigenetic Regulation Of Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process DNA Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Negative Regulation Of Gene Expression Cellular Protein Metabolic Process Gene Expression Chromatin Remodeling Regulation Of Metabolic Process Chromatin Silencing Cellular Metabolic Process DNA Packaging Nucleosome Organization Protein Metabolic Process Negative Regulation Of Transcription, DNA-templated Chromatin Assembly Or Disassembly Negative Regulation Of Nucleic Acid-templated Transcription Histone H2A Ubiquitination Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression, Epigenetic Histone Acetylation Nucleosome Assembly RNA Metabolic Process Protein-DNA Complex Assembly Internal Peptidyl-lysine Acetylation Negative Regulation Of Cellular Metabolic Process Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Negative Regulation Of Biosynthetic Process Cell Cycle Histone Deubiquitination Chromatin Assembly	Chromosome Condensation Mitotic Nuclear Division Cell Division Protein Localization To Kinetochore Protein Localization To Chromosome, Centromeric Region DNA Packaging Mitotic Cell Cycle Process Mitotic Cell Cycle Mitotic Chromosome Condensation Chromosome Segregation Protein Localization To Chromosome DNA Conformation Change Histone Phosphorylation Chromosome Organization Cell Cycle Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cell Cycle Mitotic Sister Chromatid Segregation Sister Chromatid Segregation Negative Regulation Of Protein Complex Disassembly Pronuclear Fusion Regulation Of Protein Depolymerization Peptidyl-serine Phosphorylation Regulation Of Protein Complex Disassembly Negative Regulation Of Cytoskeleton Organization Histone H3-S28 Phosphorylation Spindle Stabilization Cell Cycle Checkpoint Abscission Protein Complex Assembly DNA Metabolic Process Mitotic Spindle Midzone Assembly Cleavage Furrow Formation Regulation Of Schwann Cell Differentiation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Mitotic Spindle Elongation Positive Regulation Of Cell Cycle Negative Regulation Of Cytokinesis Spindle Midzone Assembly Aging Negative Regulation Of B Cell Apoptotic Process Attachment Of Spindle Microtubules To Kinetochore Positive Regulation Of Protein Import Into Nucleus, Translocation Organelle Organization Histone Modification Histone-serine Phosphorylation Regulation Of Protein Import Into Nucleus, Translocation Mitotic G2 DNA Damage Checkpoint Regulation Of B Cell Apoptotic Process
Tagcloud ?			annotations birc5 cdca2 cdh3 cited1 dhfr esco2 gins1 gins4 hells mc1r melana melanocyte melanocytes melk msg ncapg ncapg2 nusap1 oca2 pax3 pbk rad54l recapitulate revolutionized segregating subclasses tyms unsupervised
Tagcloud (Difference) ?			annotations birc5 cdca2 cdh3 cited1 dhfr esco2 gins1 gins4 hells mc1r melana melanocyte melanocytes melk msg ncapg ncapg2 nusap1 oca2 pax3 pbk rad54l recapitulate revolutionized segregating subclasses tyms unsupervised
Tagcloud (Intersection) ?