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HIST2H2AC and KAT2B
Number of citations of the paper that reports this interaction (PMID
8684459
)
381
Data Source:
BioGRID
(enzymatic study)
HIST2H2AC
KAT2B
Gene Name
histone cluster 2, H2ac
K(lysine) acetyltransferase 2B
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleosome
Nucleus
Extracellular Vesicular Exosome
PCAF Complex
Kinetochore
Nucleus
Nucleoplasm
Ada2/Gcn5/Ada3 Transcription Activator Complex
A Band
I Band
Actomyosin
Molecular Function
Molecular_function
DNA Binding
Protein Heterodimerization Activity
Transcription Cofactor Activity
Transcription Coactivator Activity
Histone Acetyltransferase Activity
Lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor
Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity
Protein Binding
Transcription Factor Binding
Acetyltransferase Activity
Protein Kinase Binding
Protein Complex Binding
Histone Deacetylase Binding
Biological Process
Biological_process
Chromatin Organization
Chromatin Remodeling
Transcription From RNA Polymerase I Promoter
Transcription Initiation From RNA Polymerase I Promoter
Transcription Initiation From RNA Polymerase II Promoter
Protein Acetylation
Cell Cycle Arrest
Notch Signaling Pathway
Negative Regulation Of Cell Proliferation
Gene Expression
Regulation Of Protein ADP-ribosylation
Viral Process
N-terminal Peptidyl-lysine Acetylation
Internal Peptidyl-lysine Acetylation
Peptidyl-lysine Acetylation
Cellular Response To Insulin Stimulus
Positive Regulation Of Gluconeogenesis By Positive Regulation Of Transcription From RNA Polymerase II Promoter
Histone H3 Acetylation
Histone H3-K9 Acetylation
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Rhythmic Process
Pathways
RNA Polymerase I Chain Elongation
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
Mitotic Prophase
Regulatory RNA pathways
RNA Polymerase I Promoter Clearance
Deposition of new CENPA-containing nucleosomes at the centromere
Cellular Senescence
Signaling by Wnt
HATs acetylate histones
M Phase
Amyloids
NoRC negatively regulates rRNA expression
Packaging Of Telomere Ends
Telomere Maintenance
Nucleosome assembly
RNF mutants show enhanced WNT signaling and proliferation
XAV939 inhibits tankyrase, stabilizing AXIN
DNA methylation
Transcriptional regulation by small RNAs
Meiotic recombination
DNA Damage/Telomere Stress Induced Senescence
Chromosome Maintenance
HDACs deacetylate histones
Chromatin organization
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
RNA Polymerase I Transcription
formation of the beta-catenin:TCF transactivating complex
Meiotic synapsis
Epigenetic regulation of gene expression
Senescence-Associated Secretory Phenotype (SASP)
Negative epigenetic regulation of rRNA expression
PRC2 methylates histones and DNA
Cell Cycle, Mitotic
RMTs methylate histone arginines
Chromatin modifying enzymes
Oxidative Stress Induced Senescence
TCF dependent signaling in response to WNT
RNA Polymerase I Promoter Opening
SIRT1 negatively regulates rRNA Expression
Signaling by WNT in cancer
Condensation of Prophase Chromosomes
Signaling by NOTCH1 HD Domain Mutants in Cancer
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
RNA Polymerase I Transcription Initiation
RNA Polymerase I Promoter Clearance
HATs acetylate histones
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
Generic Transcription Pathway
Pre-NOTCH Transcription and Translation
Signaling by NOTCH1
Pre-NOTCH Expression and Processing
Signaling by NOTCH1 in Cancer
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
FBXW7 Mutants and NOTCH1 in Cancer
Chromatin organization
RNA Polymerase I Transcription
Signaling by NOTCH
Notch-HLH transcription pathway
NOTCH1 Intracellular Domain Regulates Transcription
Chromatin modifying enzymes
Signaling by NOTCH1 PEST Domain Mutants in Cancer
YAP1- and WWTR1 (TAZ)-stimulated gene expression
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Drugs
Diseases
GWAS
Protein-Protein Interactions
65 interactors:
ANP32A
ATXN7L3
BAP1
BARD1
BAZ1B
BMI1
BRCA1
CDY1
CHFR
COPRS
CRP
CTCFL
CTDP1
DDB2
DNMT3L
EIF2AK2
EP300
GATAD2A
GATAD2B
HAT1
HDAC2
HIST1H2BA
HIST1H3A
HIST1H4A
HIST2H2BE
HIST2H4A
KAT2A
KAT2B
KAT5
KAT7
MSL2
MYSM1
NAP1L4
NCAPH
NCL
NPM1
PARP10
PBRM1
PELP1
PRMT5
PRMT7
RAG1
RBBP4
RCC1
RNF168
RNF2
RNF20
RNF8
SART3
SIRT7
SSRP1
TAF15
TAF1A
TAF1B
TCF20
TSPY1
TSSK6
UBC
UBE2B
UBR2
UIMC1
USP12
USP16
USP22
USP46
116 interactors:
ACTN1
ACTN2
AKT1
AR
ARNTL
ATF4
ATXN3
BRCA2
CCNA2
CCND1
CCNT1
CDC25B
CDCA4
CDK2
CDKN1B
CDT1
CEBPB
CEP250
CIITA
CLOCK
CNTN2
CREBBP
CTBP1
CTNNB1
CUX1
DACH2
DEK
EP300
ESRRA
ETV1
GATAD2A
GATAD2B
H3F3A
HIPK2
HIST1H1A
HIST1H1B
HIST1H2AB
HIST1H2BB
HIST1H3A
HIST1H4A
HIST2H2AC
HIST2H2BE
HIST2H3C
HIST3H3
HIST4H4
HMGA1
HMGN2
HNF1A
HNRNPU
HSD11B2
HTT
ING1
IRF1
IRF2
IRF7
JDP2
KLF10
KLF13
KLF2
MAPK14
MAPRE1
MDM2
MECOM
MYC
MYOD1
NCOA1
NCOA3
NCOA4
NFATC1
NFE2
NFE4
NOTCH1
NOTCH3
NPAS2
NR1H3
NR4A1
NRIP1
ONECUT1
PARP1
PDK1
PGR
PLAGL1
PNMA1
POLR2A
PTF1A
RAB11A
RARA
RB1
RBPJ
RELA
RPS6KB1
RPS6KB2
SAT2
SATB1
SERBP1
SERTAD1
SERTAD2
SIRT2
SMAD1
SMAD2
SMAD3
SRC
SRCAP
TACC2
TAL1
TCF3
TMF1
TP53
TP63
TP73
TTF1
TWIST1
UBE2D1
UBE2D3
XRCC6
YY1
Entrez ID
8338
8850
HPRD ID
09107
06780
Ensembl ID
ENSG00000184260
ENSG00000114166
Uniprot IDs
Q16777
Q92831
PDB IDs
1CM0
1JM4
1N72
1WUG
1WUM
1ZS5
2RNW
2RNX
3GG3
Enriched GO Terms of Interacting Partners
?
Chromatin Organization
Chromosome Organization
Chromatin Modification
Histone Modification
Organelle Organization
Regulation Of Gene Expression
Nucleobase-containing Compound Metabolic Process
Regulation Of RNA Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Protein Modification Process
Regulation Of RNA Biosynthetic Process
Cellular Nitrogen Compound Metabolic Process
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Histone Ubiquitination
Regulation Of Gene Expression, Epigenetic
Regulation Of Nitrogen Compound Metabolic Process
Nitrogen Compound Metabolic Process
DNA Metabolic Process
Transcription, DNA-templated
RNA Biosynthetic Process
Negative Regulation Of Gene Expression
Cellular Protein Metabolic Process
Gene Expression
Chromatin Remodeling
Regulation Of Metabolic Process
Chromatin Silencing
Cellular Metabolic Process
DNA Packaging
Nucleosome Organization
Protein Metabolic Process
Negative Regulation Of Transcription, DNA-templated
Chromatin Assembly Or Disassembly
Negative Regulation Of Nucleic Acid-templated Transcription
Histone H2A Ubiquitination
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Gene Expression, Epigenetic
Histone Acetylation
Nucleosome Assembly
RNA Metabolic Process
Protein-DNA Complex Assembly
Internal Peptidyl-lysine Acetylation
Negative Regulation Of Cellular Metabolic Process
Peptidyl-lysine Acetylation
Internal Protein Amino Acid Acetylation
Negative Regulation Of Biosynthetic Process
Cell Cycle
Histone Deubiquitination
Chromatin Assembly
Positive Regulation Of Gene Expression
Positive Regulation Of Macromolecule Biosynthetic Process
Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Positive Regulation Of Transcription, DNA-templated
Regulation Of RNA Biosynthetic Process
Regulation Of Gene Expression
RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Positive Regulation Of Cellular Biosynthetic Process
Regulation Of Transcription, DNA-templated
Gene Expression
Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Cellular Metabolic Process
Regulation Of Nitrogen Compound Metabolic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Cellular Macromolecule Biosynthetic Process
Negative Regulation Of Transcription, DNA-templated
Macromolecule Biosynthetic Process
RNA Metabolic Process
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of Gene Expression
Negative Regulation Of RNA Biosynthetic Process
Positive Regulation Of Metabolic Process
Transcription From RNA Polymerase II Promoter
Negative Regulation Of Biosynthetic Process
Cellular Nitrogen Compound Metabolic Process
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Regulation Of Metabolic Process
Nitrogen Compound Metabolic Process
Biosynthetic Process
Negative Regulation Of Cellular Metabolic Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Organ Development
Chromosome Organization
Chromatin Organization
Response To Stress
Regulation Of Cell Differentiation
Response To Organic Substance
Regulation Of Cell Proliferation
Regulation Of Cellular Process
Regulation Of Cell Cycle
Cellular Response To Organic Substance
Organelle Organization
System Development
Developmental Process
Cellular Metabolic Process
Anatomical Structure Development
Tagcloud
?
accumbens
brn2
decondensed
dmnt1
dnmt3a
erg1
exceptionally
fox3
foxg1
gadd45a
gadd45b
hdac11
homer1
kat3a
kat3b
kat5
multilineage
multipotent
nef1
neg
neun
neurobiol
neurobiology
neuroplasticity
nfl
nuclei
periodicals
pons
syt1
Tagcloud (Difference)
?
accumbens
brn2
decondensed
dmnt1
dnmt3a
erg1
exceptionally
fox3
foxg1
gadd45a
gadd45b
hdac11
homer1
kat3a
kat3b
kat5
multilineage
multipotent
nef1
neg
neun
neurobiol
neurobiology
neuroplasticity
nfl
nuclei
periodicals
pons
syt1
Tagcloud (Intersection)
?