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HIST2H2AC and BARD1
Number of citations of the paper that reports this interaction (PMID
19916563
)
2
Data Source:
BioGRID
(enzymatic study)
HIST2H2AC
BARD1
Gene Name
histone cluster 2, H2ac
BRCA1 associated RING domain 1
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleosome
Nucleus
Extracellular Vesicular Exosome
Ubiquitin Ligase Complex
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
BRCA1-BARD1 Complex
Intracellular Membrane-bounded Organelle
BRCA1-A Complex
Molecular Function
Molecular_function
DNA Binding
Protein Heterodimerization Activity
RNA Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Ligase Activity
Kinase Binding
Protein Homodimerization Activity
Protein Heterodimerization Activity
Biological Process
Biological_process
Tissue Homeostasis
DNA Repair
Cellular Response To DNA Damage Stimulus
Cell Cycle Arrest
Protein Ubiquitination
Negative Regulation Of MRNA 3'-end Processing
Regulation Of Phosphorylation
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of Protein Catabolic Process
Negative Regulation Of Protein Export From Nucleus
Protein K6-linked Ubiquitination
Pathways
RNA Polymerase I Chain Elongation
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
Mitotic Prophase
Regulatory RNA pathways
RNA Polymerase I Promoter Clearance
Deposition of new CENPA-containing nucleosomes at the centromere
Cellular Senescence
Signaling by Wnt
HATs acetylate histones
M Phase
Amyloids
NoRC negatively regulates rRNA expression
Packaging Of Telomere Ends
Telomere Maintenance
Nucleosome assembly
RNF mutants show enhanced WNT signaling and proliferation
XAV939 inhibits tankyrase, stabilizing AXIN
DNA methylation
Transcriptional regulation by small RNAs
Meiotic recombination
DNA Damage/Telomere Stress Induced Senescence
Chromosome Maintenance
HDACs deacetylate histones
Chromatin organization
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
RNA Polymerase I Transcription
formation of the beta-catenin:TCF transactivating complex
Meiotic synapsis
Epigenetic regulation of gene expression
Senescence-Associated Secretory Phenotype (SASP)
Negative epigenetic regulation of rRNA expression
PRC2 methylates histones and DNA
Cell Cycle, Mitotic
RMTs methylate histone arginines
Chromatin modifying enzymes
Oxidative Stress Induced Senescence
TCF dependent signaling in response to WNT
RNA Polymerase I Promoter Opening
SIRT1 negatively regulates rRNA Expression
Signaling by WNT in cancer
Condensation of Prophase Chromosomes
Drugs
Diseases
GWAS
Neuroblastoma (
22941191
21124317
)
Neuroblastoma (high-risk) (
19412175
)
Protein-Protein Interactions
65 interactors:
ANP32A
ATXN7L3
BAP1
BARD1
BAZ1B
BMI1
BRCA1
CDY1
CHFR
COPRS
CRP
CTCFL
CTDP1
DDB2
DNMT3L
EIF2AK2
EP300
GATAD2A
GATAD2B
HAT1
HDAC2
HIST1H2BA
HIST1H3A
HIST1H4A
HIST2H2BE
HIST2H4A
KAT2A
KAT2B
KAT5
KAT7
MSL2
MYSM1
NAP1L4
NCAPH
NCL
NPM1
PARP10
PBRM1
PELP1
PRMT5
PRMT7
RAG1
RBBP4
RCC1
RNF168
RNF2
RNF20
RNF8
SART3
SIRT7
SSRP1
TAF15
TAF1A
TAF1B
TCF20
TSPY1
TSSK6
UBC
UBE2B
UBR2
UIMC1
USP12
USP16
USP22
USP46
107 interactors:
ACP1
AKIP1
AP1B1
ASH2L
ATP1B1
ATP1B3
BCCIP
BCL3
BRCA1
BRD7
BRIP1
CAP1
CASC1
CCDC136
CEP70
CHD3
CNTN4
COL1A1
COMMD1
CRIPAK
CSTF1
DCC
DDX39B
EWSR1
EXOC5
FAM9B
FEZ1
FKBP1A
FKBP2
FKBP3
FUCA1
GIT1
GOLGA2
GPRASP2
H2AFX
HAP1
HIST2H2AC
HNRNPC
HNRNPLL
HSPA14
IDI1
IKBKAP
ING5
KAT5
KAT7
KBTBD7
KRT40
LDOC1
LGALS3
LGALS8
LRIF1
MDC1
MRPS22
MSH2
MSH3
MSH6
MT2A
ND1
NFKBIA
NPC2
OLA1
PCBP2
PDXK
PDZD8
PIAS1
PIAS4
POLR2A
POLR2H
POMZP3
POU2F1
PSMA7
PTN
RBBP8
RBMY2BP
RPS20
SELENBP1
SETDB1
SMCHD1
SNRNP200
SNX3
SPAG5
SRSF2
TCERG1
TMEM248
TOP1
TP53
TRAF1
TRAPPC11
TRAPPC8
TULP2
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2E2
UBE2E3
UBE2N
UBE2U
UBE2W
UBE3A
UBR5
UBXN1
WDR61
XRCC6
ZFP64
ZHX1
ZNF121
Entrez ID
8338
580
HPRD ID
09107
03354
Ensembl ID
ENSG00000184260
ENSG00000138376
Uniprot IDs
Q16777
Q99728
PDB IDs
1JM7
2NTE
2R1Z
3C5R
3FA2
Enriched GO Terms of Interacting Partners
?
Chromatin Organization
Chromosome Organization
Chromatin Modification
Histone Modification
Organelle Organization
Regulation Of Gene Expression
Nucleobase-containing Compound Metabolic Process
Regulation Of RNA Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Protein Modification Process
Regulation Of RNA Biosynthetic Process
Cellular Nitrogen Compound Metabolic Process
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Histone Ubiquitination
Regulation Of Gene Expression, Epigenetic
Regulation Of Nitrogen Compound Metabolic Process
Nitrogen Compound Metabolic Process
DNA Metabolic Process
Transcription, DNA-templated
RNA Biosynthetic Process
Negative Regulation Of Gene Expression
Cellular Protein Metabolic Process
Gene Expression
Chromatin Remodeling
Regulation Of Metabolic Process
Chromatin Silencing
Cellular Metabolic Process
DNA Packaging
Nucleosome Organization
Protein Metabolic Process
Negative Regulation Of Transcription, DNA-templated
Chromatin Assembly Or Disassembly
Negative Regulation Of Nucleic Acid-templated Transcription
Histone H2A Ubiquitination
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Gene Expression, Epigenetic
Histone Acetylation
Nucleosome Assembly
RNA Metabolic Process
Protein-DNA Complex Assembly
Internal Peptidyl-lysine Acetylation
Negative Regulation Of Cellular Metabolic Process
Peptidyl-lysine Acetylation
Internal Protein Amino Acid Acetylation
Negative Regulation Of Biosynthetic Process
Cell Cycle
Histone Deubiquitination
Chromatin Assembly
Cellular Response To DNA Damage Stimulus
DNA Repair
Protein Polyubiquitination
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Cellular Response To Stress
Nitrogen Compound Metabolic Process
Double-strand Break Repair
DNA Metabolic Process
Gene Expression
Chromosome Organization
Regulation Of Metabolic Process
Protein K48-linked Ubiquitination
Regulation Of Nitrogen Compound Metabolic Process
RNA Metabolic Process
Protein Modification By Small Protein Conjugation
RNA Biosynthetic Process
Transcription, DNA-templated
Regulation Of Protein Ubiquitination
Cellular Metabolic Process
Regulation Of Gene Expression
Positive Regulation Of Metabolic Process
Regulation Of RNA Metabolic Process
Response To Stress
Cell Cycle Checkpoint
DNA Recombination
Negative Regulation Of Cellular Metabolic Process
Regulation Of RNA Biosynthetic Process
Macromolecule Biosynthetic Process
Protein Ubiquitination
Positive Regulation Of Cellular Metabolic Process
Meiotic Mismatch Repair
Cellular Macromolecule Biosynthetic Process
Ubiquitin-dependent Protein Catabolic Process
Regulation Of Nucleic Acid-templated Transcription
Modification-dependent Protein Catabolic Process
Chromatin Organization
DNA Damage Checkpoint
Cellular Macromolecule Catabolic Process
Immune System Process
Viral Process
Cell Cycle
Proteolysis Involved In Cellular Protein Catabolic Process
Organelle Organization
Cellular Protein Catabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Regulation Of Transcription, DNA-templated
Tagcloud
?
10ng
agreed
atr
belonged
biosynthetic
biphenyls
brca2
dioxin
fancd2
figf
hands
immunoblots
impulses
kcnma1
lactational
mycn
ndl
neurobiological
npy4r
ontology
operator6
pcbs
performances
projection
rad51
scn1a
summation
transcriptomic
validating
Tagcloud (Difference)
?
10ng
agreed
atr
belonged
biosynthetic
biphenyls
brca2
dioxin
fancd2
figf
hands
immunoblots
impulses
kcnma1
lactational
mycn
ndl
neurobiological
npy4r
ontology
operator6
pcbs
performances
projection
rad51
scn1a
summation
transcriptomic
validating
Tagcloud (Intersection)
?