HIST2H2AC and ANP32A

Number of citations of the paper that reports this interaction (PMID 15136563)
33

Data Source:
BioGRID (pull down)

		HIST2H2AC	ANP32A
Gene Name		histone cluster 2, H2ac	acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleosome Nucleus Extracellular Vesicular Exosome	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Perinuclear Region Of Cytoplasm
	Molecular Function	Molecular_function DNA Binding Protein Heterodimerization Activity	Protein Binding Poly(A) RNA Binding
	Biological Process	Biological_process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Nucleocytoplasmic Transport Gene Expression Intracellular Signal Transduction
Pathways		RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mitotic Prophase Regulatory RNA pathways RNA Polymerase I Promoter Clearance Deposition of new CENPA-containing nucleosomes at the centromere Cellular Senescence Signaling by Wnt HATs acetylate histones M Phase Amyloids NoRC negatively regulates rRNA expression Packaging Of Telomere Ends Telomere Maintenance Nucleosome assembly RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN DNA methylation Transcriptional regulation by small RNAs Meiotic recombination DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance HDACs deacetylate histones Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling RNA Polymerase I Transcription formation of the beta-catenin:TCF transactivating complex Meiotic synapsis Epigenetic regulation of gene expression Senescence-Associated Secretory Phenotype (SASP) Negative epigenetic regulation of rRNA expression PRC2 methylates histones and DNA Cell Cycle, Mitotic RMTs methylate histone arginines Chromatin modifying enzymes Oxidative Stress Induced Senescence TCF dependent signaling in response to WNT RNA Polymerase I Promoter Opening SIRT1 negatively regulates rRNA Expression Signaling by WNT in cancer Condensation of Prophase Chromosomes	Regulation of mRNA stability by proteins that bind AU-rich elements HuR stabilizes mRNA
Drugs
Diseases
GWAS			Esophageal cancer ( 21642993)
Protein-Protein Interactions		65 interactors: ANP32A ATXN7L3 BAP1 BARD1 BAZ1B BMI1 BRCA1 CDY1 CHFR COPRS CRP CTCFL CTDP1 DDB2 DNMT3L EIF2AK2 EP300 GATAD2A GATAD2B HAT1 HDAC2 HIST1H2BA HIST1H3A HIST1H4A HIST2H2BE HIST2H4A KAT2A KAT2B KAT5 KAT7 MSL2 MYSM1 NAP1L4 NCAPH NCL NPM1 PARP10 PBRM1 PELP1 PRMT5 PRMT7 RAG1 RBBP4 RCC1 RNF168 RNF2 RNF20 RNF8 SART3 SIRT7 SSRP1 TAF15 TAF1A TAF1B TCF20 TSPY1 TSSK6 UBC UBE2B UBR2 UIMC1 USP12 USP16 USP22 USP46	27 interactors: ADAP1 APEX1 ATXN1 AXIN1 CHAF1A E4F1 ELAVL1 HIST1H3A HIST1H4A HIST2H2AC HIST2H2BE HIST3H3 HIST4H4 HSPB3 KPNA1 KPNA5 KPNA6 MAP1B NSFL1C PCBP1 PGR PPARG PTPRC SET TAF1A THRB XPO1
Entrez ID		8338	8125
HPRD ID		09107	09014
Ensembl ID		ENSG00000184260	ENSG00000140350
Uniprot IDs		Q16777	P39687
PDB IDs			2JE0 2JE1
Enriched GO Terms of Interacting Partners?		Chromatin Organization Chromosome Organization Chromatin Modification Histone Modification Organelle Organization Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Protein Modification Process Regulation Of RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Histone Ubiquitination Regulation Of Gene Expression, Epigenetic Regulation Of Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process DNA Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Negative Regulation Of Gene Expression Cellular Protein Metabolic Process Gene Expression Chromatin Remodeling Regulation Of Metabolic Process Chromatin Silencing Cellular Metabolic Process DNA Packaging Nucleosome Organization Protein Metabolic Process Negative Regulation Of Transcription, DNA-templated Chromatin Assembly Or Disassembly Negative Regulation Of Nucleic Acid-templated Transcription Histone H2A Ubiquitination Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression, Epigenetic Histone Acetylation Nucleosome Assembly RNA Metabolic Process Protein-DNA Complex Assembly Internal Peptidyl-lysine Acetylation Negative Regulation Of Cellular Metabolic Process Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Negative Regulation Of Biosynthetic Process Cell Cycle Histone Deubiquitination Chromatin Assembly	DNA Replication-dependent Nucleosome Assembly Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromatin Silencing At RDNA Nucleosome Assembly Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Chromatin Assembly Negative Regulation Of Transcription, DNA-templated Nucleocytoplasmic Transport Nuclear Transport Nucleosome Organization Chromatin Assembly Or Disassembly Protein-DNA Complex Assembly DNA Packaging Chromatin Silencing Negative Regulation Of Cellular Metabolic Process DNA Methylation On Cytosine Cytoplasmic Transport DNA Conformation Change Gene Expression DNA Metabolic Process Negative Regulation Of Gene Expression, Epigenetic NLS-bearing Protein Import Into Nucleus Telomere Maintenance Regulation Of Nitrogen Compound Metabolic Process DNA Modification Regulation Of Gene Expression, Epigenetic Nucleobase-containing Compound Metabolic Process Cellular Macromolecular Complex Assembly Gene Silencing Regulation Of Metabolic Process Histone H4-K20 Demethylation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Chromosome Organization Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Megakaryocyte Differentiation Regulation Of RNA Metabolic Process Intracellular Transport Protein Localization To Nucleus DNA Methylation Nitrogen Compound Metabolic Process Demethylation Negative Regulation Of Hematopoietic Progenitor Cell Differentiation Organelle Organization
Tagcloud ?			achn brdu capg capping chd4 chromodomain coded constrast cyclind1 helicase icpl illustrated isotope judged lentivirus lysates miapaca2 p53wt pp32 pp32r1 pp32r1y140h proteome r248w reside reverted shuttling transduced untransduced
Tagcloud (Difference) ?			achn brdu capg capping chd4 chromodomain coded constrast cyclind1 helicase icpl illustrated isotope judged lentivirus lysates miapaca2 p53wt pp32 pp32r1 pp32r1y140h proteome r248w reside reverted shuttling transduced untransduced
Tagcloud (Intersection) ?