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HIST2H2AC and RBBP4
Number of citations of the paper that reports this interaction (PMID
12628926
)
122
Data Source:
HPRD
(in vitro)
HIST2H2AC
RBBP4
Gene Name
histone cluster 2, H2ac
retinoblastoma binding protein 4
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleosome
Nucleus
Extracellular Vesicular Exosome
Nuclear Chromatin
Nucleus
Nucleoplasm
Sin3 Complex
NuRD Complex
NURF Complex
CAF-1 Complex
ESC/E(Z) Complex
Protein Complex
Molecular Function
Molecular_function
DNA Binding
Protein Heterodimerization Activity
RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding
RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding
Protein Binding
DNA-dependent ATPase Activity
Nucleosomal DNA Binding
Histone Binding
Histone Deacetylase Binding
Biological Process
Biological_process
G2/M Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle
DNA Replication
Chromatin Organization
Nucleosome Assembly
DNA Replication-dependent Nucleosome Assembly
DNA Replication-independent Nucleosome Assembly
Chromatin Remodeling
Transcription, DNA-templated
Regulation Of Transcription, DNA-templated
Negative Regulation Of Cell Proliferation
Gene Expression
Chromatin Assembly
CENP-A Containing Nucleosome Assembly
Regulation Of Gene Expression, Epigenetic
ATP-dependent Chromatin Remodeling
Negative Regulation Of Gene Expression, Epigenetic
Regulation Of Cell Cycle
Pathways
RNA Polymerase I Chain Elongation
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
Mitotic Prophase
Regulatory RNA pathways
RNA Polymerase I Promoter Clearance
Deposition of new CENPA-containing nucleosomes at the centromere
Cellular Senescence
Signaling by Wnt
HATs acetylate histones
M Phase
Amyloids
NoRC negatively regulates rRNA expression
Packaging Of Telomere Ends
Telomere Maintenance
Nucleosome assembly
RNF mutants show enhanced WNT signaling and proliferation
XAV939 inhibits tankyrase, stabilizing AXIN
DNA methylation
Transcriptional regulation by small RNAs
Meiotic recombination
DNA Damage/Telomere Stress Induced Senescence
Chromosome Maintenance
HDACs deacetylate histones
Chromatin organization
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
RNA Polymerase I Transcription
formation of the beta-catenin:TCF transactivating complex
Meiotic synapsis
Epigenetic regulation of gene expression
Senescence-Associated Secretory Phenotype (SASP)
Negative epigenetic regulation of rRNA expression
PRC2 methylates histones and DNA
Cell Cycle, Mitotic
RMTs methylate histone arginines
Chromatin modifying enzymes
Oxidative Stress Induced Senescence
TCF dependent signaling in response to WNT
RNA Polymerase I Promoter Opening
SIRT1 negatively regulates rRNA Expression
Signaling by WNT in cancer
Condensation of Prophase Chromosomes
Chromosome Maintenance
Chromatin organization
HDACs deacetylate histones
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
RNA Polymerase I Transcription Initiation
RNA Polymerase I Transcription
RNA Polymerase I Promoter Clearance
Deposition of new CENPA-containing nucleosomes at the centromere
Cellular Senescence
Epigenetic regulation of gene expression
G2/M Transition
G0 and Early G1
PRC2 methylates histones and DNA
Cell Cycle, Mitotic
Chromatin modifying enzymes
Nucleosome assembly
Oxidative Stress Induced Senescence
Mitotic G2-G2/M phases
Mitotic G1-G1/S phases
Polo-like kinase mediated events
Drugs
Diseases
GWAS
Protein-Protein Interactions
65 interactors:
ANP32A
ATXN7L3
BAP1
BARD1
BAZ1B
BMI1
BRCA1
CDY1
CHFR
COPRS
CRP
CTCFL
CTDP1
DDB2
DNMT3L
EIF2AK2
EP300
GATAD2A
GATAD2B
HAT1
HDAC2
HIST1H2BA
HIST1H3A
HIST1H4A
HIST2H2BE
HIST2H4A
KAT2A
KAT2B
KAT5
KAT7
MSL2
MYSM1
NAP1L4
NCAPH
NCL
NPM1
PARP10
PBRM1
PELP1
PRMT5
PRMT7
RAG1
RBBP4
RCC1
RNF168
RNF2
RNF20
RNF8
SART3
SIRT7
SSRP1
TAF15
TAF1A
TAF1B
TCF20
TSPY1
TSSK6
UBC
UBE2B
UBR2
UIMC1
USP12
USP16
USP22
USP46
50 interactors:
AEBP2
ANXA7
BCL11B
BRCA1
BRMS1
BRMS1L
CDKN1A
CHAF1B
CREB1
CREBBP
DHX30
EED
ESR1
EZH2
GATAD2B
HAT1
HDAC1
HDAC2
HDAC3
HDAC4
HIST1H1A
HIST2H2AC
HIST2H3C
HIST2H4A
HIST3H3
HMOX2
ING1
LINC00152
LMNA
MBD2
MBD3
MBD3L2
MTA1
MTA2
NR2E3
RB1
RBBP7
RBP1
RPN1
RPN2
SAP30
SIN3A
SMN1
SP1
SP3
SPEN
SUV39H1
TK1
TSSK3
XRCC6
Entrez ID
8338
5928
HPRD ID
09107
04232
Ensembl ID
ENSG00000184260
ENSG00000162521
Uniprot IDs
Q16777
Q09028
PDB IDs
2XU7
3GFC
Enriched GO Terms of Interacting Partners
?
Chromatin Organization
Chromosome Organization
Chromatin Modification
Histone Modification
Organelle Organization
Regulation Of Gene Expression
Nucleobase-containing Compound Metabolic Process
Regulation Of RNA Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Protein Modification Process
Regulation Of RNA Biosynthetic Process
Cellular Nitrogen Compound Metabolic Process
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Histone Ubiquitination
Regulation Of Gene Expression, Epigenetic
Regulation Of Nitrogen Compound Metabolic Process
Nitrogen Compound Metabolic Process
DNA Metabolic Process
Transcription, DNA-templated
RNA Biosynthetic Process
Negative Regulation Of Gene Expression
Cellular Protein Metabolic Process
Gene Expression
Chromatin Remodeling
Regulation Of Metabolic Process
Chromatin Silencing
Cellular Metabolic Process
DNA Packaging
Nucleosome Organization
Protein Metabolic Process
Negative Regulation Of Transcription, DNA-templated
Chromatin Assembly Or Disassembly
Negative Regulation Of Nucleic Acid-templated Transcription
Histone H2A Ubiquitination
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Gene Expression, Epigenetic
Histone Acetylation
Nucleosome Assembly
RNA Metabolic Process
Protein-DNA Complex Assembly
Internal Peptidyl-lysine Acetylation
Negative Regulation Of Cellular Metabolic Process
Peptidyl-lysine Acetylation
Internal Protein Amino Acid Acetylation
Negative Regulation Of Biosynthetic Process
Cell Cycle
Histone Deubiquitination
Chromatin Assembly
Chromatin Organization
Chromosome Organization
Negative Regulation Of Gene Expression
Regulation Of Gene Expression, Epigenetic
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Gene Expression, Epigenetic
Chromatin Modification
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Cellular Metabolic Process
Gene Expression
Regulation Of Transcription From RNA Polymerase II Promoter
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Regulation Of Gene Expression
Transcription, DNA-templated
Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Transcription, DNA-templated
Cellular Nitrogen Compound Metabolic Process
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
RNA Biosynthetic Process
Organelle Organization
Histone Modification
Regulation Of RNA Metabolic Process
Cellular Macromolecule Biosynthetic Process
Regulation Of Nitrogen Compound Metabolic Process
Macromolecule Biosynthetic Process
Nitrogen Compound Metabolic Process
RNA Metabolic Process
Cellular Metabolic Process
Chromatin Remodeling
Histone Deacetylation
Positive Regulation Of Transcription, DNA-templated
Protein Deacetylation
Biosynthetic Process
ATP-dependent Chromatin Remodeling
Positive Regulation Of Cellular Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Gene Expression
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Cellular Biosynthetic Process
Regulation Of Metabolic Process
Rhythmic Process
Chromatin Silencing
Histone H3-K9 Modification
Positive Regulation Of Metabolic Process
Metabolic Process
Tagcloud
?
bfls
borjeson
charged
coregulator
deacetylase
disordered
fog1
forssman
gal4
homeodomain
impair
implicates
insert
lehmann
lymphoblastic
mta1
nucleosome
nurd
nurf55
overlaps
pair
phf6
pocket
propeller
recognizing
remodeling
repression
su
top
Tagcloud (Difference)
?
bfls
borjeson
charged
coregulator
deacetylase
disordered
fog1
forssman
gal4
homeodomain
impair
implicates
insert
lehmann
lymphoblastic
mta1
nucleosome
nurd
nurf55
overlaps
pair
phf6
pocket
propeller
recognizing
remodeling
repression
su
top
Tagcloud (Intersection)
?