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HIST2H2AC and RNF168
Number of citations of the paper that reports this interaction (PMID
22980979
)
38
Data Source:
BioGRID
(enzymatic study)
HIST2H2AC
RNF168
Gene Name
histone cluster 2, H2ac
ring finger protein 168, E3 ubiquitin protein ligase
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleosome
Nucleus
Extracellular Vesicular Exosome
Ubiquitin Ligase Complex
Nucleus
Nucleoplasm
Cytoplasm
Site Of Double-strand Break
Molecular Function
Molecular_function
DNA Binding
Protein Heterodimerization Activity
Chromatin Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Ligase Activity
Nucleosome Binding
Histone Binding
Ubiquitin Binding
K63-linked Polyubiquitin Binding
Biological Process
Biological_process
Double-strand Break Repair
Ubiquitin-dependent Protein Catabolic Process
Cellular Response To DNA Damage Stimulus
Response To Ionizing Radiation
Protein Ubiquitination
Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter
Histone H2A Monoubiquitination
Interstrand Cross-link Repair
Histone H2A-K13 Ubiquitination
Histone H2A-K15 Ubiquitination
Isotype Switching
Positive Regulation Of DNA Repair
Protein K63-linked Ubiquitination
Histone H2A K63-linked Ubiquitination
Pathways
RNA Polymerase I Chain Elongation
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
Mitotic Prophase
Regulatory RNA pathways
RNA Polymerase I Promoter Clearance
Deposition of new CENPA-containing nucleosomes at the centromere
Cellular Senescence
Signaling by Wnt
HATs acetylate histones
M Phase
Amyloids
NoRC negatively regulates rRNA expression
Packaging Of Telomere Ends
Telomere Maintenance
Nucleosome assembly
RNF mutants show enhanced WNT signaling and proliferation
XAV939 inhibits tankyrase, stabilizing AXIN
DNA methylation
Transcriptional regulation by small RNAs
Meiotic recombination
DNA Damage/Telomere Stress Induced Senescence
Chromosome Maintenance
HDACs deacetylate histones
Chromatin organization
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
RNA Polymerase I Transcription
formation of the beta-catenin:TCF transactivating complex
Meiotic synapsis
Epigenetic regulation of gene expression
Senescence-Associated Secretory Phenotype (SASP)
Negative epigenetic regulation of rRNA expression
PRC2 methylates histones and DNA
Cell Cycle, Mitotic
RMTs methylate histone arginines
Chromatin modifying enzymes
Oxidative Stress Induced Senescence
TCF dependent signaling in response to WNT
RNA Polymerase I Promoter Opening
SIRT1 negatively regulates rRNA Expression
Signaling by WNT in cancer
Condensation of Prophase Chromosomes
Drugs
Diseases
GWAS
Fat distribution (HIV) (
21897333
)
Protein-Protein Interactions
65 interactors:
ANP32A
ATXN7L3
BAP1
BARD1
BAZ1B
BMI1
BRCA1
CDY1
CHFR
COPRS
CRP
CTCFL
CTDP1
DDB2
DNMT3L
EIF2AK2
EP300
GATAD2A
GATAD2B
HAT1
HDAC2
HIST1H2BA
HIST1H3A
HIST1H4A
HIST2H2BE
HIST2H4A
KAT2A
KAT2B
KAT5
KAT7
MSL2
MYSM1
NAP1L4
NCAPH
NCL
NPM1
PARP10
PBRM1
PELP1
PRMT5
PRMT7
RAG1
RBBP4
RCC1
RNF168
RNF2
RNF20
RNF8
SART3
SIRT7
SSRP1
TAF15
TAF1A
TAF1B
TCF20
TSPY1
TSSK6
UBC
UBE2B
UBR2
UIMC1
USP12
USP16
USP22
USP46
12 interactors:
H2AFX
HIST2H2AC
JMJD1C
KDM4A
KIAA0368
LAPTM5
RABGEF1
RNF11
UBC
UBE2D3
UBE2E1
UBE2G2
Entrez ID
8338
165918
HPRD ID
09107
08190
Ensembl ID
ENSG00000184260
ENSG00000163961
Uniprot IDs
Q16777
Q8IYW5
PDB IDs
3L11
4GB0
Enriched GO Terms of Interacting Partners
?
Chromatin Organization
Chromosome Organization
Chromatin Modification
Histone Modification
Organelle Organization
Regulation Of Gene Expression
Nucleobase-containing Compound Metabolic Process
Regulation Of RNA Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Protein Modification Process
Regulation Of RNA Biosynthetic Process
Cellular Nitrogen Compound Metabolic Process
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Histone Ubiquitination
Regulation Of Gene Expression, Epigenetic
Regulation Of Nitrogen Compound Metabolic Process
Nitrogen Compound Metabolic Process
DNA Metabolic Process
Transcription, DNA-templated
RNA Biosynthetic Process
Negative Regulation Of Gene Expression
Cellular Protein Metabolic Process
Gene Expression
Chromatin Remodeling
Regulation Of Metabolic Process
Chromatin Silencing
Cellular Metabolic Process
DNA Packaging
Nucleosome Organization
Protein Metabolic Process
Negative Regulation Of Transcription, DNA-templated
Chromatin Assembly Or Disassembly
Negative Regulation Of Nucleic Acid-templated Transcription
Histone H2A Ubiquitination
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Gene Expression, Epigenetic
Histone Acetylation
Nucleosome Assembly
RNA Metabolic Process
Protein-DNA Complex Assembly
Internal Peptidyl-lysine Acetylation
Negative Regulation Of Cellular Metabolic Process
Peptidyl-lysine Acetylation
Internal Protein Amino Acid Acetylation
Negative Regulation Of Biosynthetic Process
Cell Cycle
Histone Deubiquitination
Chromatin Assembly
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Protein Catabolic Process
Protein K48-linked Ubiquitination
Protein Polyubiquitination
Cellular Macromolecule Catabolic Process
Proteolysis
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Catabolic Process
Negative Regulation Of Cytokine Production
ER-associated Ubiquitin-dependent Protein Catabolic Process
Cell Cycle Checkpoint
Protein Monoubiquitination
Negative Regulation Of Type I Interferon Production
Cellular Protein Metabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress
Chromatin Organization
Cellular Protein Modification Process
Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Regulation Of DNA-templated Transcription In Response To Stress
Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
TRIF-dependent Toll-like Receptor Signaling Pathway
Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Negative Regulation Of Ubiquitin-protein Transferase Activity
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Negative Regulation Of Kit Signaling Pathway
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Ubiquitin-protein Transferase Activity
Positive Regulation Of Ligase Activity
Toll-like Receptor 4 Signaling Pathway
Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Regulation Of Ubiquitin-protein Transferase Activity
Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Cellular Response To Hypoxia
Cellular Response To Decreased Oxygen Levels
Negative Regulation Of Protein Ubiquitination
Chromosome Organization
Regulation Of Type I Interferon Production
Toll-like Receptor Signaling Pathway
Cellular Response To Oxygen Levels
Protein Metabolic Process
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Tagcloud
?
53bp1
atm
brca1
cdk1
comparatively
coordinates
cytosol
ddr
enables
exit
flanking
genotoxic
h2a
homologous
impairs
interphase
joining
kinetochores
ligases
localize
mitosis
mitotic
plk1
properly
recombination
rnf8
s1618
spatiotemporally
ubiquitinated
Tagcloud (Difference)
?
53bp1
atm
brca1
cdk1
comparatively
coordinates
cytosol
ddr
enables
exit
flanking
genotoxic
h2a
homologous
impairs
interphase
joining
kinetochores
ligases
localize
mitosis
mitotic
plk1
properly
recombination
rnf8
s1618
spatiotemporally
ubiquitinated
Tagcloud (Intersection)
?