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HIST2H2AC and TAF1A
Number of citations of the paper that reports this interaction (PMID
15136563
)
33
Data Source:
BioGRID
(pull down)
HIST2H2AC
TAF1A
Gene Name
histone cluster 2, H2ac
TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa
Image
No pdb structure
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleosome
Nucleus
Extracellular Vesicular Exosome
RNA Polymerase I Transcription Factor Complex
Nucleus
Nucleoplasm
Microtubule Cytoskeleton
Intracellular Membrane-bounded Organelle
Molecular Function
Molecular_function
DNA Binding
Protein Heterodimerization Activity
DNA Binding
Protein Binding
Biological Process
Biological_process
Chromatin Silencing At RDNA
Transcription From RNA Polymerase I Promoter
Transcription Initiation From RNA Polymerase I Promoter
Transcription Elongation From RNA Polymerase I Promoter
Termination Of RNA Polymerase I Transcription
Transcription From RNA Polymerase II Promoter
Gene Expression
Regulation Of Gene Expression, Epigenetic
Negative Regulation Of Gene Expression, Epigenetic
Pathways
RNA Polymerase I Chain Elongation
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
Mitotic Prophase
Regulatory RNA pathways
RNA Polymerase I Promoter Clearance
Deposition of new CENPA-containing nucleosomes at the centromere
Cellular Senescence
Signaling by Wnt
HATs acetylate histones
M Phase
Amyloids
NoRC negatively regulates rRNA expression
Packaging Of Telomere Ends
Telomere Maintenance
Nucleosome assembly
RNF mutants show enhanced WNT signaling and proliferation
XAV939 inhibits tankyrase, stabilizing AXIN
DNA methylation
Transcriptional regulation by small RNAs
Meiotic recombination
DNA Damage/Telomere Stress Induced Senescence
Chromosome Maintenance
HDACs deacetylate histones
Chromatin organization
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
RNA Polymerase I Transcription
formation of the beta-catenin:TCF transactivating complex
Meiotic synapsis
Epigenetic regulation of gene expression
Senescence-Associated Secretory Phenotype (SASP)
Negative epigenetic regulation of rRNA expression
PRC2 methylates histones and DNA
Cell Cycle, Mitotic
RMTs methylate histone arginines
Chromatin modifying enzymes
Oxidative Stress Induced Senescence
TCF dependent signaling in response to WNT
RNA Polymerase I Promoter Opening
SIRT1 negatively regulates rRNA Expression
Signaling by WNT in cancer
Condensation of Prophase Chromosomes
NoRC negatively regulates rRNA expression
RNA Polymerase I Chain Elongation
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
RNA Polymerase I Transcription Initiation
RNA Polymerase I Transcription
RNA Polymerase I Transcription Termination
RNA Polymerase I Promoter Escape
RNA Polymerase I Promoter Clearance
Epigenetic regulation of gene expression
SIRT1 negatively regulates rRNA Expression
Negative epigenetic regulation of rRNA expression
Drugs
Diseases
GWAS
Protein-Protein Interactions
65 interactors:
ANP32A
ATXN7L3
BAP1
BARD1
BAZ1B
BMI1
BRCA1
CDY1
CHFR
COPRS
CRP
CTCFL
CTDP1
DDB2
DNMT3L
EIF2AK2
EP300
GATAD2A
GATAD2B
HAT1
HDAC2
HIST1H2BA
HIST1H3A
HIST1H4A
HIST2H2BE
HIST2H4A
KAT2A
KAT2B
KAT5
KAT7
MSL2
MYSM1
NAP1L4
NCAPH
NCL
NPM1
PARP10
PBRM1
PELP1
PRMT5
PRMT7
RAG1
RBBP4
RCC1
RNF168
RNF2
RNF20
RNF8
SART3
SIRT7
SSRP1
TAF15
TAF1A
TAF1B
TCF20
TSPY1
TSSK6
UBC
UBE2B
UBR2
UIMC1
USP12
USP16
USP22
USP46
21 interactors:
ANP32A
C11orf57
CD3EAP
ESR1
HIST1H3A
HIST1H4A
HIST2H2AC
HIST2H2BE
HIST3H3
HIST4H4
JMJD6
RRN3
RUNX2
SET
TAF12
TAF1B
TAF1C
TAF1D
TBP
TP53
UBTF
Entrez ID
8338
9015
HPRD ID
09107
05362
Ensembl ID
ENSG00000184260
ENSG00000143498
Uniprot IDs
Q16777
A8K4K5
B4DS21
Q15573
PDB IDs
Enriched GO Terms of Interacting Partners
?
Chromatin Organization
Chromosome Organization
Chromatin Modification
Histone Modification
Organelle Organization
Regulation Of Gene Expression
Nucleobase-containing Compound Metabolic Process
Regulation Of RNA Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Protein Modification Process
Regulation Of RNA Biosynthetic Process
Cellular Nitrogen Compound Metabolic Process
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Histone Ubiquitination
Regulation Of Gene Expression, Epigenetic
Regulation Of Nitrogen Compound Metabolic Process
Nitrogen Compound Metabolic Process
DNA Metabolic Process
Transcription, DNA-templated
RNA Biosynthetic Process
Negative Regulation Of Gene Expression
Cellular Protein Metabolic Process
Gene Expression
Chromatin Remodeling
Regulation Of Metabolic Process
Chromatin Silencing
Cellular Metabolic Process
DNA Packaging
Nucleosome Organization
Protein Metabolic Process
Negative Regulation Of Transcription, DNA-templated
Chromatin Assembly Or Disassembly
Negative Regulation Of Nucleic Acid-templated Transcription
Histone H2A Ubiquitination
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Gene Expression, Epigenetic
Histone Acetylation
Nucleosome Assembly
RNA Metabolic Process
Protein-DNA Complex Assembly
Internal Peptidyl-lysine Acetylation
Negative Regulation Of Cellular Metabolic Process
Peptidyl-lysine Acetylation
Internal Protein Amino Acid Acetylation
Negative Regulation Of Biosynthetic Process
Cell Cycle
Histone Deubiquitination
Chromatin Assembly
Chromatin Silencing At RDNA
Negative Regulation Of Gene Expression, Epigenetic
Transcription Initiation From RNA Polymerase I Promoter
Transcription From RNA Polymerase I Promoter
Chromatin Silencing
DNA-templated Transcription, Initiation
Termination Of RNA Polymerase I Transcription
Transcription Elongation From RNA Polymerase I Promoter
Regulation Of Gene Expression, Epigenetic
DNA-templated Transcription, Elongation
Gene Silencing
Negative Regulation Of Gene Expression
Gene Expression
Nucleobase-containing Compound Metabolic Process
DNA-templated Transcription, Termination
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Chromatin Organization
Cellular Nitrogen Compound Metabolic Process
Chromosome Organization
Nitrogen Compound Metabolic Process
Chromatin Assembly
Regulation Of Gene Expression
Chromatin Assembly Or Disassembly
Transcription, DNA-templated
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Protein-DNA Complex Assembly
RNA Biosynthetic Process
Negative Regulation Of Transcription, DNA-templated
Regulation Of RNA Metabolic Process
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
DNA Packaging
Regulation Of Nitrogen Compound Metabolic Process
Negative Regulation Of Biosynthetic Process
Nucleosome Assembly
Cellular Macromolecule Biosynthetic Process
DNA Replication-dependent Nucleosome Assembly
Macromolecule Biosynthetic Process
DNA Conformation Change
Nucleosome Organization
RNA Metabolic Process
DNA Methylation On Cytosine
RRNA Transcription
Regulation Of Metabolic Process
Organelle Organization
Biosynthetic Process
Negative Regulation Of Cellular Metabolic Process
Tagcloud
?
analysed
blocking
c8
coding
crc
frameshift
gc
harboured
heterogeneity
instability
intratumoural
ith
microsatellite
mononucleotide
msi
mss
mutational
regional
ribosomal
rrna
somatic
strand
summary
taf1b
taf1c
tata
tbp
tumourigenesis
ubf
Tagcloud (Difference)
?
analysed
blocking
c8
coding
crc
frameshift
gc
harboured
heterogeneity
instability
intratumoural
ith
microsatellite
mononucleotide
msi
mss
mutational
regional
ribosomal
rrna
somatic
strand
summary
taf1b
taf1c
tata
tbp
tumourigenesis
ubf
Tagcloud (Intersection)
?