Wiki-Pi
About
Search
People
Updates
Search
H2AC20 and HDAC2
Number of citations of the paper that reports this interaction (PubMedID
12626569
)
0
Data Source:
BioGRID
(enzymatic study)
H2AC20
HDAC2
Description
H2A clustered histone 20
histone deacetylase 2
Image
GO Annotations
Cellular Component
Nucleosome
Nucleus
Chromosome
Extracellular Exosome
Histone Deacetylase Complex
Chromosome, Telomeric Region
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
NuRD Complex
Protein-containing Complex
ESC/E(Z) Complex
Sin3-type Complex
Molecular Function
DNA Binding
Structural Constituent Of Chromatin
Protein Heterodimerization Activity
Transcription Coregulator Binding
Chromatin Binding
RNA Binding
Histone Deacetylase Activity
Protein Binding
Hydrolase Activity
Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides
Deacetylase Activity
Enzyme Binding
Heat Shock Protein Binding
Nucleosomal DNA Binding
Protein Lysine Deacetylase Activity
Histone Binding
Histone Deacetylase Binding
NF-kappaB Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
DNA-binding Transcription Factor Binding
Histone Deacetylase Activity, Hydrolytic Mechanism
Protein Decrotonylase Activity
Histone Decrotonylase Activity
Protein De-2-hydroxyisobutyrylase Activity
Protein Lysine Delactylase Activity
Promoter-specific Chromatin Binding
Biological Process
Heterochromatin Formation
Negative Regulation Of Transcription By RNA Polymerase II
Response To Amphetamine
Cardiac Muscle Hypertrophy
Chromatin Organization
Chromatin Remodeling
Positive Regulation Of Cell Population Proliferation
Response To Xenobiotic Stimulus
Epidermal Cell Differentiation
Positive Regulation Of Epithelial To Mesenchymal Transition
Negative Regulation Of Transcription By Competitive Promoter Binding
Negative Regulation Of Neuron Projection Development
Dendrite Development
Negative Regulation Of Cell Migration
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Response To Caffeine
Heterochromatin Formation
Response To Lipopolysaccharide
Positive Regulation Of Interleukin-1 Production
Positive Regulation Of Tumor Necrosis Factor Production
Circadian Regulation Of Gene Expression
Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway
Cellular Response To Heat
Response To Nicotine
Protein Modification Process
Response To Cocaine
Odontogenesis Of Dentin-containing Tooth
Regulation Of Cell Fate Specification
Embryonic Digit Morphogenesis
Negative Regulation Of Apoptotic Process
Positive Regulation Of Proteolysis
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Behavioral Response To Ethanol
Rhythmic Process
Positive Regulation Of Oligodendrocyte Differentiation
Progesterone Receptor Signaling Pathway
Response To Hyperoxia
Hair Follicle Placode Formation
Negative Regulation Of Dendritic Spine Development
Eyelid Development In Camera-type Eye
Fungiform Papilla Formation
Cellular Response To Hydrogen Peroxide
Cellular Response To Retinoic Acid
Cellular Response To Transforming Growth Factor Beta Stimulus
Response To Alcohol
Positive Regulation Of Male Mating Behavior
Negative Regulation Of Stem Cell Population Maintenance
Positive Regulation Of Stem Cell Population Maintenance
Cellular Response To Dopamine
Response To Amyloid-beta
Regulation Of Stem Cell Differentiation
Pathways
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Recognition and association of DNA glycosylase with site containing an affected purine
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Cleavage of the damaged purine
Meiotic synapsis
Packaging Of Telomere Ends
Pre-NOTCH Transcription and Translation
Formation of the beta-catenin:TCF transactivating complex
Formation of the beta-catenin:TCF transactivating complex
PRC2 methylates histones and DNA
Condensation of Prophase Chromosomes
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
HDACs deacetylate histones
HATs acetylate histones
HATs acetylate histones
RMTs methylate histone arginines
SIRT1 negatively regulates rRNA expression
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
NoRC negatively regulates rRNA expression
NoRC negatively regulates rRNA expression
B-WICH complex positively regulates rRNA expression
DNA methylation
Transcriptional regulation by small RNAs
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
UCH proteinases
Ub-specific processing proteases
Metalloprotease DUBs
Deposition of new CENPA-containing nucleosomes at the centromere
Assembly of the ORC complex at the origin of replication
RNA Polymerase I Promoter Opening
RNA Polymerase I Promoter Escape
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Estrogen-dependent gene expression
Meiotic recombination
HCMV Early Events
HCMV Late Events
Transcriptional regulation of granulopoiesis
Inhibition of DNA recombination at telomere
Defective pyroptosis
Negative Regulation of CDH1 Gene Transcription
Amyloid fiber formation
Chromatin modifications during the maternal to zygotic transition (MZT)
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Regulation of endogenous retroelements by KRAB-ZFP proteins
Regulation of endogenous retroelements by KRAB-ZFP proteins
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)
Regulation of PD-L1(CD274) transcription
p75NTR negatively regulates cell cycle via SC1
NOTCH1 Intracellular Domain Regulates Transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
HDACs deacetylate histones
Notch-HLH transcription pathway
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
NoRC negatively regulates rRNA expression
SUMOylation of chromatin organization proteins
Regulation of TP53 Activity through Acetylation
RNA Polymerase I Transcription Initiation
Regulation of PTEN gene transcription
Regulation of PTEN gene transcription
Regulation of MECP2 expression and activity
MECP2 regulates neuronal receptors and channels
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
EGR2 and SOX10-mediated initiation of Schwann cell myelination
EGR2 and SOX10-mediated initiation of Schwann cell myelination
Potential therapeutics for SARS
STAT3 nuclear events downstream of ALK signaling
Negative Regulation of CDH1 Gene Transcription
Factors involved in megakaryocyte development and platelet production
Regulation of endogenous retroelements by KRAB-ZFP proteins
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)
Drugs
Pravastatin
Lovastatin
Theophylline
Valproic acid
Valproic acid
Simvastatin
Atorvastatin
Fluvastatin
Aminophylline
Decitabine
Oxtriphylline
Vorinostat
Vorinostat
Belinostat
Pracinostat
Romidepsin
Romidepsin
Panobinostat
Phenylbutyric acid
Tixocortol
Mocetinostat
Entinostat
Abexinostat
Givinostat
Pyroxamide
Diseases
GWAS
Event free survival in diffuse large B-cell lymphoma treated with immunochemotherapy (
26460308
)
Metabolite levels (
23823483
)
Interacting Genes
72 interacting genes:
ANP32A
APP
ATXN7L3
BAP1
BARD1
BMI1
BRCA1
CDY1
CEBPA
CRP
CSTF1
CTCFL
DDB2
DNMT3L
EIF2AK2
EP300
ESR1
FBL
GATAD2A
GATAD2B
H2BC1
H4C14
HAT1
HDAC2
KAT2A
KAT2B
KAT5
KAT7
MSL2
MYSM1
NAA40
NAP1L4
NCAPH
NCL
NPM1
PARP10
PBRM1
PELP1
POT1
PRMT5
PRMT7
RAG1
RBBP4
RCC1
RNF168
RNF2
RNF20
RNF8
SART3
SIRT7
STK38
TAF15
TAF1A
TAF1B
TCF20
TRIM37
TSPY1
TSSK6
UBC
UBE2B
UBE2H
UBR2
UIMC1
USP10
USP12
USP16
USP2
USP22
USP46
USP51
USP7
USP8
97 interacting genes:
ANTXR1
APPL1
ARID4A
AURKA
BRCA1
BRMS1
BRMS1L
BUB3
CDC20
CDH1
CDKN1A
CDYL
CEBPA
CHFR
CIRSR
CSNK2A1
CSNK2A2
CTBP1
CUL4B
CYTOR
DAXX
DDX20
DMAP1
DNMT1
DNMT3B
EED
EID2
ERCC6
FKBP3
GATA3
H2AC1
H2AC20
H2BC21
H3-4
H3C1
HDAC1
HDAC10
HDAC7
HIF1A
HIF1AN
HOPX
IFRD1
IKZF1
IKZF4
ING1
JUP
MAD1L1
MBD2
MTA1
MXD1
NACC2
NRIP1
PA2G4
PADI4
PHB2
PHF21A
PIAS4
PML
PPARD
PPP1R8
PTMA
RBBP4
RBBP7
RBP1
RCOR1
RELA
RFX5
RUNX3
SALL1
SAP30
SETDB1
SIN3A
SMAD2
SMARCA5
SMYD1
SNW1
SP1
SP3
SPEN
SS18L1
STAT3
SUMO2
SUV39H1
SYK
TFCP2
THRA
THRB
TMEM132D
TOP2A
TOP2B
TP53
UBC
USP4
VHL
YY1
ZBTB16
ZNF461
Entrez ID
8338
3066
HPRD ID
09107
05521
Ensembl ID
ENSG00000184260
ENSG00000196591
Uniprot IDs
Q16777
Q92769
PDB IDs
6Y5E
7U0G
7U0I
7U0J
8DK5
8EVG
8EVH
8EVI
8EVJ
8SPS
8SPU
8SYP
3MAX
4LXZ
4LY1
5IWG
5IX0
6G3O
6WBW
6WBZ
6WHN
6WHO
6WHQ
6WHZ
6WI3
6XDM
6XEB
6XEC
7JS8
7KBG
7KBH
7LTG
7LTK
7LTL
7MOS
7MOT
7MOX
7MOY
7MOZ
7ZZO
7ZZP
7ZZR
7ZZS
7ZZT
7ZZU
7ZZW
8A0B
8BPA
8BPB
8BPC
8C60
9DTQ
Enriched GO Terms of Interacting Partners
?
Chromatin Organization
Chromatin Remodeling
Nucleus
Histone Binding
Nucleoplasm
Epigenetic Regulation Of Gene Expression
Chromatin Binding
Chromosome
Protein Modification Process
Macromolecule Metabolic Process
Post-translational Protein Modification
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Protein Metabolic Process
Regulation Of RNA Metabolic Process
Regulation Of DNA Repair
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Cellular Response To Stress
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Metabolic Process
Regulation Of Cell Cycle
Regulation Of Primary Metabolic Process
Regulation Of Gene Expression
Histone H4 Acetyltransferase Activity
Cysteine-type Deubiquitinase Activity
Negative Regulation Of Metabolic Process
Positive Regulation Of Metabolic Process
Histone H2A Deubiquitinase Activity
Protein Deubiquitination
Regulation Of DNA Metabolic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Histone Acetyltransferase Activity
DNA Damage Response
Protein Modification By Small Protein Removal
Negative Regulation Of Biosynthetic Process
Transferase Activity
Nucleic Acid Metabolic Process
DNA Metabolic Process
Negative Regulation Of Gene Expression, Epigenetic
Cysteine-type Peptidase Activity
Protein-containing Complex
Positive Regulation Of DNA-templated Transcription
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Metabolic Process
Regulation Of RNA Biosynthetic Process
Negative Regulation Of Transcription By RNA Polymerase II
Nucleus
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Regulation Of RNA Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Chromatin Organization
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Gene Expression
Regulation Of Macromolecule Metabolic Process
Nucleoplasm
Regulation Of Primary Metabolic Process
Regulation Of Metabolic Process
Chromatin Remodeling
DNA Binding
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of Macromolecule Metabolic Process
Transcription Corepressor Activity
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of DNA-templated Transcription
Sin3-type Complex
Histone Deacetylase Binding
Chromatin Binding
Positive Regulation Of Metabolic Process
Regulation Of Developmental Process
Positive Regulation Of Macromolecule Biosynthetic Process
Histone Deacetylase Complex
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Developmental Process
Negative Regulation Of Stem Cell Population Maintenance
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Epigenetic Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Transcription Repressor Complex
Negative Regulation Of Developmental Process
Negative Regulation Of Gene Expression, Epigenetic
Heterochromatin Formation
Protein-containing Complex
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Regulation Of Cell Differentiation
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?