RNF2 and AMBRA1

Number of citations of the paper that reports this interaction (PubMedID 24980959)
53

Data Source:
BioGRID (two hybrid, affinity chromatography technology, pull down, enzymatic study)

		RNF2	AMBRA1
Description		ring finger protein 2	autophagy and beclin 1 regulator 1
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Euchromatin Heterochromatin Sex Chromatin Nucleus Nucleoplasm Chromosome Cytoplasm Nuclear Body PcG Protein Complex PRC1 Complex MLL1 Complex	Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Autophagosome Endoplasmic Reticulum Cytosol Cytoskeleton Focal Adhesion Axoneme Cytoplasmic Vesicle Intracellular Membrane-bounded Organelle Phagocytic Vesicle Perinuclear Region Of Cytoplasm Anchoring Junction Cul4-RING E3 Ubiquitin Ligase Complex
	Molecular Function	Chromatin Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity RING-like Zinc Finger Domain Binding Histone H2AK119 Ubiquitin Ligase Activity	Protein Binding Protein Phosphatase Binding Ubiquitin Protein Ligase Binding GTPase Binding Protein Phosphatase Activator Activity Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Mitotic Cell Cycle Gastrulation With Mouth Forming Second Chromatin Organization Chromatin Remodeling Germ Cell Development Anterior/posterior Axis Specification Gene Expression Protein Ubiquitination Epigenetic Regulation Of Gene Expression Negative Regulation Of DNA-binding Transcription Factor Activity	Autophagosome Assembly G1/S Transition Of Mitotic Cell Cycle Protein Polyubiquitination Mitophagy Regulation Of Transcription By RNA Polymerase II Autophagy Nervous System Development Negative Regulation Of Cell Population Proliferation Cellular Response To Starvation Positive Regulation Of Autophagy Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Protein Ubiquitination Neural Tube Development Cell Differentiation Response To Nutrient Levels Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Regulatory T Cell Differentiation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Response To Mitochondrial Depolarisation Positive Regulation Of Mitophagy Positive Regulation Of Free Ubiquitin Chain Polymerization Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6	Macroautophagy
Drugs
Diseases
GWAS		Clopidogrel active metabolite levels ( 28207573) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Obesity-related traits ( 23251661)	Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 28552196) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Hypertrophic cardiomyopathy (sarcomere positive) ( 33495597) Immunoglobulin A ( 20694011) Insulin-related traits (multivariate analysis) ( 32002517) Normal facial asymmetry (angle of deformation score) ( 30631343) Schizophrenia ( 28991256 29483656 30285260) Selective IgA deficiency ( 27723758)
Interacting Genes		65 interacting genes: ABCB1 AMBRA1 BAALC BMI1 CASP3 CASP9 CBX4 CBX6 CBX7 CBX8 CIP2A DYSF ERG GMNN H2AC18 H2AC20 H2AC4 H2BC3 H3-4 KAT8 KMT2A MBD1 MTNR1A OTUD6A PCGF1 PCGF2 PCGF6 PGP PHB2 PHC1 PHC2 PLK1 PSMC4 RING1 RRM1 RYBP SBDS SCMH1 SIK1 SMURF2 SSX2 TARDBP TFCP2 TMEM132D TSC22D2 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2J1 UBE2K UBE2L3 UBE2U UBE2V1 UBE2V2 UBE2W UBE3A USP11 USP19 WASHC1	15 interacting genes: AKT1 BECN1 CCND1 CHUK GABARAP GABARAPL1 GABARAPL2 MAP1LC3A MAP1LC3B MAP1LC3C MTOR RNF2 SNCA UBC UBE2D3
Entrez ID		6045	55626
HPRD ID		07028	10975
Ensembl ID		ENSG00000121481	ENSG00000110497
Uniprot IDs		Q99496	A0A075B6T1 Q9C0C7
PDB IDs		2H0D 3GS2 3H8H 3IXS 3RPG 4R8P 4S3O 6WI7 6WI8 7ND1 8GRM 8PP7 9DBY 9DDE 9DGG	8WQR
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity PRC1 Complex PcG Protein Complex Post-translational Protein Modification Protein Polyubiquitination Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein Modification Process Nucleus Protein K48-linked Ubiquitination Ubiquitin-protein Transferase Activity Negative Regulation Of Biosynthetic Process Chromatin Organization Negative Regulation Of Macromolecule Biosynthetic Process Protein K11-linked Ubiquitination Nucleoplasm Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Proteolysis Negative Regulation Of Macromolecule Metabolic Process Chromatin Remodeling Protein Metabolic Process Modification-dependent Protein Catabolic Process Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Ubiquitin-dependent Protein Catabolic Process Ubiquitin-protein Transferase Activator Activity Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Macromolecule Catabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Protein Ubiquitination Chromatin Binding Positive Regulation Of Post-translational Protein Modification Regulation Of Protein Ubiquitination Transferase Activity Heterochromatin Formation Heterochromatin Proteasomal Protein Catabolic Process Sex Chromatin Protein Monoubiquitination Negative Regulation Of Transcription By RNA Polymerase II	Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding Autophagosome Assembly Autophagosome Maturation Autophagosome Organization Mitophagy Cellular Response To Starvation Response To Starvation Autophagy Of Mitochondrion Autophagosome Cellular Response To Nutrient Levels Macroautophagy Vacuole Organization Autophagosome Membrane Phospholipid Binding Response To Nutrient Levels Protein-containing Complex Disassembly Autophagy Ubiquitin Protein Ligase Binding Response To Iron(II) Ion Response To Iron Ion Cellular Response To Stress Beta-tubulin Binding Cellular Response To Amino Acid Starvation GABA Receptor Binding Response To Amino Acid Starvation Organelle Assembly Cellular Response To Copper Ion Cytoplasmic Vesicle Negative Regulation Of Catabolic Process Catabolic Process Negative Regulation Of Lysosome Organization Cellular Response To Oxygen-glucose Deprivation Negative Regulation Of Autophagy Response To Copper Ion Negative Regulation Of Macroautophagy Microtubule Binding Organelle Organization Endomembrane System Regulation Of Generation Of Precursor Metabolites And Energy Response To Stress Organelle Membrane Cellular Response To Decreased Oxygen Levels Response To Vitamin E Generation Of Precursor Metabolites And Energy Cellular Response To Oxygen Levels Response To Metal Ion Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Mitochondrial ATP Synthesis Coupled Electron Transport Microtubule
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