RNF2 and CASP3

Number of citations of the paper that reports this interaction (PMID 17379327)
2

Data Source:
BioGRID (enzymatic study)

		RNF2	CASP3
Gene Name		ring finger protein 2	caspase 3, apoptosis-related cysteine peptidase
Image
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Euchromatin Sex Chromatin Nucleus Nucleoplasm Nuclear Body PcG Protein Complex PRC1 Complex MLL1 Complex	Nucleus Nucleoplasm Cytosol Plasma Membrane
	Molecular Function	Chromatin Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity RING-like Zinc Finger Domain Binding	Aspartic-type Endopeptidase Activity Cysteine-type Endopeptidase Activity Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Peptidase Activity Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Cell Cycle Gastrulation With Mouth Forming Second Transcription, DNA-templated Anterior/posterior Axis Specification Histone H2A Monoubiquitination Histone H2A-K119 Monoubiquitination	B Cell Homeostasis Release Of Cytochrome C From Mitochondria Apoptotic DNA Fragmentation Proteolysis Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cellular Response To DNA Damage Stimulus Heart Development Sensory Perception Of Sound Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Response To UV Response To Wounding Extracellular Matrix Disassembly Neuron Differentiation Extracellular Matrix Organization Keratinocyte Differentiation Erythrocyte Differentiation Platelet Formation Negative Regulation Of B Cell Proliferation Glial Cell Apoptotic Process Response To Tumor Necrosis Factor Hippo Signaling T Cell Homeostasis Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Cell Fate Commitment Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Activated T Cell Proliferation Neurotrophin TRK Receptor Signaling Pathway Neuron Apoptotic Process Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intrinsic Apoptotic Signaling Pathway Execution Phase Of Apoptosis Regulation Of Apoptotic DNA Fragmentation
Pathways		Oxidative Stress Induced Senescence Cellular Senescence	SMAC binds to IAPs SMAC-mediated dissociation of IAP:caspase complexes SMAC-mediated apoptotic response Cytochrome c-mediated apoptotic response Caspase-mediated cleavage of cytoskeletal proteins Degradation of the extracellular matrix Role of DCC in regulating apoptosis Activation of caspases through apoptosome-mediated cleavage Activation of DNA fragmentation factor Apoptotic factor-mediated response Programmed Cell Death Intrinsic Pathway for Apoptosis Signalling by NGF Apoptotic cleavage of cellular proteins Cell death signalling via NRAGE, NRIF and NADE Apoptotic execution phase p75 NTR receptor-mediated signalling Stimulation of the cell death response by PAK-2p34 Apoptotic cleavage of cell adhesion proteins Signaling by Hippo Apoptosis induced DNA fragmentation Extrinsic Pathway NADE modulates death signalling
Drugs			Minocycline 5-[4-(1-Carboxymethyl-2-Oxo-Propylcarbamoyl)-Benzylsulfamoyl]-2-Hydroxy-Benzoic Acid 2-HYDROXY-5-(2-MERCAPTO-ETHYLSULFAMOYL)-BENZOIC ACID methyl (3S)-3-[(tert-butoxycarbonyl)amino]-4-oxopentanoate 1-METHYL-5-(2-PHENOXYMETHYL-PYRROLIDINE-1-SULFONYL)-1H-INDOLE-2,3-DIONE [N-(3-DIBENZYLCARBAMOYL-OXIRANECARBONYL)-HYDRAZINO]-ACETIC ACID 4-[5-(2-CARBOXY-1-FORMYL-ETHYLCARBAMOYL)-PYRIDIN-3-YL]-BENZOIC ACID (1S)-2-oxo-1-phenyl-2-[(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-5-yl)amino]ethyl acetate (1S)-1-(3-chlorophenyl)-2-oxo-2-[(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-5-yl)amino]ethyl acetate N-[3-(2-fluoroethoxy)phenyl]-N\'-(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-6-yl)butanediamide
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		54 interactors: ABCB1 AMBRA1 BMI1 CASP3 CASP9 CBX4 CBX6 CBX7 CBX8 HIST1H2AB HIST2H2AA3 HIST2H2AC HIST3H3 KAT8 KMT2A L3MBTL2 MBD1 OTUD6A PCGF1 PCGF2 PCGF3 PCGF5 PCGF6 PGP PHB2 PHC1 PSMC4 RING1 RRM1 RYBP SMURF2 SSX2 TARDBP TFCP2 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2J1 UBE2K UBE2L3 UBE2U UBE2V1 UBE2V2 UBE2W UBE3A USP11 USP19 USP7 WASH1	153 interactors: ACIN1 ADD1 AIFM1 AKAP8 AKT1 APAF1 APP AR ARHGDIA ARHGDIB ATG4D ATN1 BCAP31 BCAR1 BCL2 BECN1 BID BIRC2 BIRC3 BIRC5 BIRC6 BIRC7 BLM BMX BRCA1 CAD CASP10 CASP2 CASP4 CASP6 CASP7 CASP8 CASP9 CAST CDC27 CDC42 CDH1 CDK11B CDKN1A CFLAR COPS6 CRYAB CTNNB1 CTTN DBNL DCC DCTN1 DEDD DFFA DSG3 EIF2AK2 EIF2S1 EIF3J EIF4B EIF4G2 FYN GATA1 GLRX GMNN GOLGA3 GORASP1 GRIPAP1 GSN GZMB HCLS1 HIP1 HMGB1 HNRNPU HSPD1 HSPE1 HTT IL16 IL18 KCNIP3 KRT18 LMNB1 LYN MAP4K1 MAPK8 MAPK8IP3 MAPK9 MAPT MCL1 MDC1 MDM2 MDM4 MEF2A MET MLH1 MYL3 NDUFS1 NEDD4 NFE2L2 NMT2 PAK2 PARG PARP1 PDE10A PDE5A PICALM PIP5K1A PKN1 PKN2 PLA2G4A PLA2G4B PPP3CA PRKCQ PRKCZ PRKDC PSEN1 PSEN2 PSIP1 PSME3 PTBP1 PTGES3 PTMA PXN RABEP1 RAC1 RAD51 RASA1 RB1 RFC1 RNF2 ROCK1 SARS2 SLK SOCS5 SP1 SPTAN1 SREBF2 SRF SRP72 STAT1 STK24 STK3 STK4 TFAP2A TGM2 THAP11 TNFSF10 TOP1 TRAF1 TRAF3 UBE4B USO1 VAV1 VIM WEE1 XIAP YWHAE YWHAG ZBTB16
Entrez ID		6045	836
HPRD ID		07028	02799
Ensembl ID		ENSG00000121481	ENSG00000164305
Uniprot IDs		B3KRH1 Q99496	A8MVM1 P42574
PDB IDs		2H0D 3GS2 3H8H 3IXS 3RPG	1CP3 1GFW 1I3O 1NME 1NMQ 1NMS 1PAU 1QX3 1RE1 1RHJ 1RHK 1RHM 1RHQ 1RHR 1RHU 2C1E 2C2K 2C2M 2C2O 2CDR 2CJX 2CJY 2CNK 2CNL 2CNN 2CNO 2DKO 2H5I 2H5J 2H65 2J30 2J31 2J32 2J33 2XYG 2XYH 2XYP 2XZD 2XZT 2Y0B 3DEH 3DEI 3DEJ 3DEK 3EDQ 3GJQ 3GJR 3GJS 3GJT 3H0E 3ITN 3KJF 3PCX 3PD0 3PD1 4DCJ 4DCO 4DCP 4EHA 4EHD 4EHF 4EHH 4EHK 4EHL 4EHN 4JJE 4JQY 4JQZ 4JR0
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein Polyubiquitination Protein K48-linked Ubiquitination Cellular Protein Modification Process Histone Ubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Protein K11-linked Ubiquitination Cellular Protein Catabolic Process Chromatin Modification Cellular Macromolecule Catabolic Process Protein Catabolic Process Cellular Metabolic Process Chromatin Organization Cellular Protein Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Transcription, DNA-templated Chromosome Organization Histone Modification RNA Biosynthetic Process Protein Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Proteolysis Protein Monoubiquitination Negative Regulation Of RNA Biosynthetic Process Nitrogen Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Catabolic Process Cellular Macromolecule Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Protein K63-linked Ubiquitination Macromolecule Biosynthetic Process Metabolic Process Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Gene Expression Regulation Of Nucleic Acid-templated Transcription Gene Expression Regulation Of Metabolic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process RNA Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression	Cell Death Programmed Cell Death Apoptotic Process Death Regulation Of Cell Death Regulation Of Apoptotic Process Execution Phase Of Apoptosis Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Regulation Of Protein Metabolic Process Cellular Response To Stimulus Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Cell Communication Positive Regulation Of Cell Death Positive Regulation Of Programmed Cell Death Response To Stimulus Regulation Of Catalytic Activity Response To Stress Signal Transduction Positive Regulation Of Cellular Metabolic Process Signaling Positive Regulation Of Apoptotic Process Regulation Of Metabolic Process Regulation Of Signal Transduction Apoptotic Signaling Pathway Intracellular Signal Transduction Negative Regulation Of Programmed Cell Death Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Signaling Positive Regulation Of Catalytic Activity Regulation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Cell Death Regulation Of Endopeptidase Activity Negative Regulation Of Apoptotic Process Regulation Of Cellular Component Organization Regulation Of Peptidase Activity Positive Regulation Of Signal Transduction Regulation Of Cellular Process Regulation Of Proteolysis Cellular Response To Stress Immune System Process Multicellular Organismal Development Anatomical Structure Development Developmental Process Response To Organic Substance System Development Cell Differentiation Intrinsic Apoptotic Signaling Pathway
Tagcloud ?		aldrich ambra1 arp2 associates autophagy becn1 cul4a ddb1 e3 elusive endosomal impairs impede interactor k48 k63 ligase linkage pik3c3 potentiates scar sorting starvation suppresses ubiquitinate ubiquitination wash wasp wiskott	abeta1 accelerated amyloid apoe4 bace1 becomes deposits event hallmark hyperphosphorylation increasingly later losses nonetheless nonsynonymous nontransgenic oxys picalm posits precede proof psen1 psen2 snps sorl1 sporadic triggers turn unlikely
Tagcloud (Difference) ?		aldrich ambra1 arp2 associates autophagy becn1 cul4a ddb1 e3 elusive endosomal impairs impede interactor k48 k63 ligase linkage pik3c3 potentiates scar sorting starvation suppresses ubiquitinate ubiquitination wash wasp wiskott	abeta1 accelerated amyloid apoe4 bace1 becomes deposits event hallmark hyperphosphorylation increasingly later losses nonetheless nonsynonymous nontransgenic oxys picalm posits precede proof psen1 psen2 snps sorl1 sporadic triggers turn unlikely
Tagcloud (Intersection) ?