IKZF3 and NUDT16L1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		IKZF3	NUDT16L1
Description		IKAROS family zinc finger 3	nudix hydrolase 16 like 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleus
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Identical Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding Sequence-specific DNA Binding Metal Ion Binding Protein Heterodimerization Activity Promoter-specific Chromatin Binding	RNA Binding Protein Binding SnoRNA Binding Protein Homodimerization Activity 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] Hydrolase Activity Phosphodiesterase Decapping Endonuclease Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Mesoderm Development Response To Bacterium B Cell Differentiation T Cell Differentiation Regulation Of B Cell Proliferation B Cell Activation Regulation Of Apoptotic Process Regulation Of B Cell Differentiation Regulation Of Lymphocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II	MRNA Catabolic Process Sno(s)RNA Catabolic Process Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways
Drugs
Diseases
GWAS		Acute lymphoblastic leukemia (childhood) ( 29348612) Asthma ( 28461288 31959851 31619474) Asthma (moderate or severe) ( 30552067) Asthma and hay fever ( 24388013) Asthma or allergic disease (pleiotropy) ( 29785011) Asthma with severe exacerbations ( 32841424) Atopic march ( 26542096) Bronchial hyperresponsiveness in asthma ( 27439200) Crohn's disease ( 21102463 28067908) Eosinophil count ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Inflammatory bowel disease ( 23128233 28067908) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Lymphocyte count ( 29403010 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Marginal zone lymphoma or systemic lupus erythematosus ( 31407831) Multiple sclerosis ( 24076602 31604244) Neutrophil percentage of granulocytes ( 27863252) Pediatric autoimmune diseases ( 26301688) Polycystic ovary syndrome ( 30343302) Primary biliary cholangitis ( 20639880 23000144 30643196 28062665 19458352 26394269) Primary biliary cirrhosis ( 22961000) Refractive error ( 32231278) Rheumatoid arthritis ( 24390342 23143596 30423114) Rheumatoid arthritis (ACPA-positive) ( 24532676 23143596) Selective IgA deficiency ( 27723758) Self-reported allergy ( 23817569) Systemic lupus erythematosus ( 27399966 26502338) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic sclerosis ( 31672989) Type 1 diabetes ( 30659077 25751624) Ulcerative colitis ( 28067908 21297633 20228799)
Interacting Genes		157 interacting genes: ABLIM3 AIRIM AKAP10 AKAP9 ANKS1A AQP1 ARMC7 ARNT2 ATP6V0D1 ATP6V0D2 ATPAF2 ATXN7L2 BCAS2 BCL2L1 BLK BLZF1 BYSL CABP4 CABP5 CARD9 CATSPER1 CATSPERT CCDC102B CCDC187 CCDC24 CCDC57 CCHCR1 CDC37 CDC7 CDK4 CDKN1A CDKN2D CFAP206 CHCHD2 CHD3 CKS1B CLCNKA CRBN CRK CRYBA4 DGCR6 DTX2 EFHC1 EGLN3 EMC2 ENKD1 EXOC8 EXOSC5 FAM124B FANCG FANCL FARS2 FBF1 FHL3 FRS3 GEM GOLGA2 GOLGA6A GRAP2 GRB2 HNRNPF HNRNPLL HOXC8 HRAS IKZF1 IKZF4 IKZF5 ING5 KANK2 KAT5 KIF9 KIFC3 KLHL38 KRT19 LDOC1 LENG1 LGALS14 LMO1 LMO2 LMO4 LNX1 LONRF1 MAD2L2 MAGOHB MCM7 MCRS1 MID2 MISP MKRN3 MORN3 MRPL28 MRPL53 MYO15B NATD1 NEK6 NFKBID NME7 NOS3 NTAQ1 NUDT16L1 NXT2 OAZ3 OSGIN1 PCID2 PDZD4 PFDN5 PIK3R1 PIK3R2 PIN1 POLM POLR1C PPP1R16B PPP1R18 PRDM1 PRKAA1 PRKAA2 PRKAB2 PSMA1 PSMF1 RAD51D RBBP8 RCOR3 RHOA RNF6 RUNX1 SCNM1 SMARCB1 SMARCD1 SPG21 STAMBPL1 STK16 STK26 STX11 SUMO1 TBC1D22B TCAF1 TCAP TCEANC TCHP TEKT3 TEKT4 TFAP2D TLE5 TRAPPC6A TRIM42 TSEN15 TSGA10IP TSSK3 TSTD2 UBE2I USP2 VBP1 YES1 ZGPAT ZMYM2 ZNF587 ZNF76	52 interacting genes: APP CABP2 CEBPA ERBB2 FBXO7 HNRNPF HNRNPH1 IKZF3 INCA1 KRT31 LRRK1 METTL17 MIR122 MIR128-1 MIR128-2 MIR138-1 MIR141 MIR145 MIR18B MIR200C MIR21 MIR25 MIR31 MIR34A MIR34B MIR363 MIR451A MIR7-3 MIR9-1 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I NEDD4L NEK6 NTAQ1 PNMA1 RECK SMARCD1 TRAF2 TRAF4 TRIM68 ZRANB1
Entrez ID		22806	84309
HPRD ID		05869	15309
Ensembl ID		ENSG00000161405	ENSG00000168101
Uniprot IDs		Q9UKT9	B2RD96 K7ENA3 Q9BRJ7 W4VSQ8
PDB IDs			3KVH 5ZCJ 6CO1 6D0L 8U3S
Enriched GO Terms of Interacting Partners?		Protein Binding Nucleus Centrosome Microtubule-based Process Organelle Organization Cytoplasm Nucleoplasm Phosphotyrosine Residue Binding Cis-Golgi Network AMP-activated Protein Kinase Activity Microtubule Cytoskeleton Organization Lipid Droplet Disassembly Sperm Flagellum Microtubule Cytoskeleton Organization Involved In Mitosis Cytoskeleton Histone H2BS36 Kinase Activity [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Plasma Membrane Proton-transporting V-type ATPase Complex Axonemal A Tubule Inner Sheath Phosphatidylethanolamine Biosynthetic Process Protein K6-linked Ubiquitination Positive Regulation Of Lymphocyte Activation Regulation Of Mitotic Cell Cycle Nucleotide-activated Protein Kinase Complex Ephrin Receptor Binding Spindle Organization Microtubule Nucleation Cytoskeleton Organization Motile Cilium Regulation Of Autophagy Cyclin D2-CDK4 Complex Axonemal Microtubule Mitotic Spindle Organization Positive Regulation Of Lymphocyte Differentiation Positive Regulation Of Cell Activation Regulation Of Organelle Organization Regulation Of Mitotic Cell Cycle Phase Transition Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Regulation Of Cell Activation Regulation Of Lymphocyte Activation Hepatocyte Apoptotic Process Protein Localization To Lipid Droplet Organelle Assembly Regulation Of Cell Cycle	MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MiRNA-mediated Gene Silencing By MRNA Destabilization MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process MRNA Destabilization Negative Regulation Of Biosynthetic Process RNA Destabilization Negative Regulation Of Metabolic Process Positive Regulation Of MRNA Catabolic Process Extracellular Vesicle Regulation Of MRNA Stability Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Cell Migration Regulation Of RNA Stability Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Regulation Of Gene Expression Regulation Of Metabolic Process Positive Regulation Of Catabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Translation Regulation Of MRNA Metabolic Process Regulation Of Translation Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Interleukin-6-mediated Signaling Pathway Regulation Of Angiogenesis Regulation Of Vasculature Development Extracellular Space Regulation Of Signal Transduction Regulation Of Developmental Process Regulation Of Locomotion Regulation Of Cell Migration Negative Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Negative Regulation Of Multicellular Organismal Process Regulation Of Cell Motility Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Protein Metabolic Process Negative Regulation Of Cytokine Production Regulation Of Cellular Response To Growth Factor Stimulus
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