IKZF3 and PFDN5

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		IKZF3	PFDN5
Gene Name		IKAROS family zinc finger 3 (Aiolos)	prefoldin subunit 5
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane	Nucleus Cytoplasm Prefoldin Complex
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding Metal Ion Binding Protein Heterodimerization Activity	Transcription Corepressor Activity Protein Binding Unfolded Protein Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Mesoderm Development Regulation Of B Cell Proliferation B Cell Activation Regulation Of Apoptotic Process Regulation Of B Cell Differentiation Regulation Of Lymphocyte Differentiation	Regulation Of Transcription, DNA-templated Protein Folding Cellular Protein Metabolic Process Negative Regulation Of Transcription, DNA-templated 'de Novo' Posttranslational Protein Folding Retina Development In Camera-type Eye Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways			Protein folding Prefoldin mediated transfer of substrate to CCT/TriC Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding Chaperonin-mediated protein folding
Drugs
Diseases
GWAS		Crohn's disease ( 21102463) Inflammatory bowel disease ( 23128233) Primary biliary cirrhosis ( 19458352 23000144 20639880) Rheumatoid arthritis ( 20453842) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Ulcerative colitis ( 21297633)
Protein-Protein Interactions		71 interactors: ABLIM3 AES AKAP9 AQP1 ARMC7 ARNT2 ATPAF2 BCAS2 BCL2L1 C1orf109 CABP5 CDKN1A CDKN2D CHCHD2 CHD3 DGCR6 EFHC1 EMC2 EXOC8 EXOSC5 FANCL FARS2 FBF1 GEM GRB2 HNRNPF HRAS IKZF1 IKZF4 IKZF5 ING5 KAT5 KRT19 LGALS14 LMO1 LMO2 MAGOHB MORN3 MRPL28 MRPL53 NATD1 NEK6 OAZ3 OSGIN1 PCID2 PFDN5 PIK3R2 PIN1 POLM POLR1C PPP1R16B PRKAA1 PRKAB2 PSMA1 RAD51D RBBP8 RCOR3 RHOA SPG21 STAMBPL1 STK16 STX11 TBC1D22B TCAF1 TEKT4 TRAPPC6A TRIM42 TSSK3 TSTD2 UBE2I ZGPAT	13 interactors: BRMS1 CALCOCO2 GLRX3 IKBKG IKZF3 ITSN1 MYC PFDN6 PSME3 TP73 TRIM28 TUBA1B TUBA3C
Entrez ID		22806	5204
HPRD ID		05869	05359
Ensembl ID			ENSG00000123349
Uniprot IDs		Q9UKT9	Q99471
PDB IDs
Enriched GO Terms of Interacting Partners?		Cell Cycle Cell Cycle Process Mitotic Cell Cycle Process Organelle Organization Gene Expression Mitotic Cell Cycle Negative Regulation Of Cellular Metabolic Process Cellular Response To Stress Cellular Response To DNA Damage Stimulus Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Cellular Nitrogen Compound Metabolic Process Response To Radiation Regulation Of Cell Cycle Positive Regulation Of Metabolic Process Cellular Response To Organonitrogen Compound Response To Hormone Nucleobase-containing Compound Metabolic Process Cell Cycle Checkpoint RNA Metabolic Process Response To Ionizing Radiation Cell Cycle Arrest Regulation Of Signal Transduction Insulin Receptor Signaling Pathway Response To Organic Substance Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Mitotic Cell Cycle Immune System Process Response To Stress Nitrogen Compound Metabolic Process Signal Transduction In Response To DNA Damage Negative Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Response To Hormone Stimulus Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Negative Regulation Of Cell Cycle Cellular Macromolecule Biosynthetic Process Transcription, DNA-templated Regulation Of Signaling Ammonium Transmembrane Transport Biosynthetic Process Macromolecule Biosynthetic Process Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Insulin Stimulus Cellular Response To Organic Substance Response To Organonitrogen Compound	'de Novo' Posttranslational Protein Folding Regulation Of Apoptotic Process 'de Novo' Protein Folding Regulation Of Cell Death Positive Regulation Of Response To DNA Damage Stimulus Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Response To DNA Damage Stimulus Cellular Response To DNA Damage Stimulus Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Protein Complex Assembly Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Neuron Death Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Positive Regulation Of Protein Metabolic Process Response To Gamma Radiation Regulation Of Neuron Death Protein Folding Cellular Response To UV Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Negative Regulation Of Transcription From RNA Polymerase II Promoter Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Transcription, DNA-templated Cellular Protein Complex Assembly Cellular Response To Stress DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Catalytic Activity RNA Biosynthetic Process Positive Regulation Of Metabolic Process Gene Expression Positive Regulation Of Protein Modification Process Negative Regulation Of DNA Demethylation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Fibroblast Apoptotic Process Signal Transduction In Response To DNA Damage Cellular Response To Light Stimulus Mitotic DNA Damage Checkpoint Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Tagcloud ?		17q12 amplicon cab2 ccct darpp32 endued gc han haplotype histogenesis immumohistochemical implied per1 perld1 ppp1r1b q21 rs11869286 rs1877031 rs881844 rs9972882 sequenom signet stard3 steroidogenic tcap titin tma top2a znfn1a3	auf1 autonomous becomes bidirectional cdc25c ddb1 deregulated deregulation grpr hspd1 hyperparathyroidism hyperplastic irreversible mandatory naca nodular oasl oligonucleotide parathyroid physiologic polb prdx2 repressed responds subtraction taldo1 tpd52 vil2 xrcc1
Tagcloud (Difference) ?		17q12 amplicon cab2 ccct darpp32 endued gc han haplotype histogenesis immumohistochemical implied per1 perld1 ppp1r1b q21 rs11869286 rs1877031 rs881844 rs9972882 sequenom signet stard3 steroidogenic tcap titin tma top2a znfn1a3	auf1 autonomous becomes bidirectional cdc25c ddb1 deregulated deregulation grpr hspd1 hyperparathyroidism hyperplastic irreversible mandatory naca nodular oasl oligonucleotide parathyroid physiologic polb prdx2 repressed responds subtraction taldo1 tpd52 vil2 xrcc1
Tagcloud (Intersection) ?