TFG and ARHGEF16

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		TFG	ARHGEF16
Gene Name		TRK-fused gene	Rho guanine nucleotide exchange factor (GEF) 16
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Extracellular Vesicular Exosome	Cytosol
	Molecular Function	Signal Transducer Activity Protein Binding Identical Protein Binding	Rho Guanyl-nucleotide Exchange Factor Activity Protein Binding Rho GTPase Binding PDZ Domain Binding Receptor Tyrosine Kinase Binding
	Biological Process	Signal Transduction Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling	Small GTPase Mediated Signal Transduction Activation Of Rac GTPase Activity Activation Of Cdc42 GTPase Activity Positive Regulation Of Apoptotic Process Neurotrophin TRK Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Cell Chemotaxis Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Apoptotic Signaling Pathway
Pathways			Rho GTPase cycle Signaling by GPCR GPCR downstream signaling Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE Signaling by Rho GTPases NRAGE signals death through JNK G alpha (12/13) signalling events p75 NTR receptor-mediated signalling
Drugs
Diseases
GWAS			Response to statin therapy ( 20339536)
Protein-Protein Interactions		30 interactors: ANXA11 ARHGEF16 ARL15 BOLL C14orf1 CEP55 CRMP1 CSTF2 EWSR1 GBP2 GPRASP1 GRB2 HNRNPF KIAA1377 MAGED1 MAPK1IP1L MED21 MYOT PEF1 PIN1 PLSCR1 PTPN6 RBPMS RIPPLY2 SEC24A SPG21 STAT5B TRIM25 TSSK2 VPS37C	4 interactors: LNX1 MAPK1IP1L TFG YWHAQ
Entrez ID		10342	27237
HPRD ID		03932	12478
Ensembl ID		ENSG00000114354	ENSG00000130762
Uniprot IDs		Q05BK6 Q92734	B3KTS4 B4DJM7 Q5VV41
PDB IDs			1X6B
Enriched GO Terms of Interacting Partners?		Response To Cytokine Cytokine-mediated Signaling Pathway Cell Separation After Cytokinesis Response To Interferon-beta JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Growth Hormone Receptor Signaling Pathway Interferon-gamma-mediated Signaling Pathway Cellular Response To Growth Hormone Stimulus Cellular Response To Cytokine Stimulus Regulation Of B Cell Differentiation Immune System Process Cellular Response To Interferon-gamma Defense Response Positive Regulation Of Immune Response Acute-phase Response Response To Growth Hormone Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Interferon-gamma Cellular Response To Organic Substance Mitotic Cytokinesis Negative Regulation Of Type I Interferon Production Platelet Activation JAK-STAT Cascade Positive Regulation Of T Cell Activation Regulation Of Pathway-restricted SMAD Protein Phosphorylation Response To Organic Substance Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Homotypic Cell-cell Adhesion Regulation Of Cell Activation Neurotrophin Signaling Pathway Innate Immune Response Cell Surface Receptor Signaling Pathway Abortive Mitotic Cell Cycle G-protein Coupled Receptor Catabolic Process Positive Regulation Of Cell-cell Adhesion Regulation Of Innate Immune Response Regulation Of Immune Response Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity Cytokinesis, Completion Of Separation Acute Inflammatory Response Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Signal Transduction Negative Regulation Of Viral Process Positive Regulation Of Immune System Process T Cell Costimulation Receptor Metabolic Process Cell Cycle Immune Response-activating Cell Surface Receptor Signaling Pathway Response To External Stimulus Regulation Of Body Fluid Levels
Tagcloud ?		architecture associate cargo carriers coat coated compartments concentrate copii cup en ergic exit export flexible interface interorganellar laden leave neighboring octameric polymers route slows submicron tight traverse trk uncoating
Tagcloud (Difference) ?		architecture associate cargo carriers coat coated compartments concentrate copii cup en ergic exit export flexible interface interorganellar laden leave neighboring octameric polymers route slows submicron tight traverse trk uncoating
Tagcloud (Intersection) ?