TRIM37 and H2AC20

Number of citations of the paper that reports this interaction (PubMedID 25470042)
42

Data Source:
BioGRID (enzymatic study)

		TRIM37	H2AC20
Description		tripartite motif containing 37	H2A clustered histone 20
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GO Annotations	Cellular Component	Chromosome Cytoplasm Peroxisome Peroxisomal Membrane Cytosol Membrane Aggresome ESC/E(Z) Complex Perinuclear Region Of Cytoplasm	Nucleosome Nucleus Chromosome Extracellular Exosome
	Molecular Function	Chromatin Binding Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Transferase Activity Enzyme Binding Ubiquitin Protein Ligase Binding Protein Homodimerization Activity Metal Ion Binding Ubiquitin Protein Ligase Activity Histone H2AK119 Ubiquitin Ligase Activity	DNA Binding Structural Constituent Of Chromatin Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Monoubiquitination Protein Import Into Peroxisome Matrix Protein Ubiquitination Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of DNA-templated Transcription Negative Regulation Of Centriole Replication Protein Stabilization Protein Autoubiquitination Aggresome Assembly	Heterochromatin Formation
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence HDACs deacetylate histones HATs acetylate histones HATs acetylate histones RMTs methylate histone arginines SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 UCH proteinases Ub-specific processing proteases Metalloprotease DUBs Deposition of new CENPA-containing nucleosomes at the centromere Assembly of the ORC complex at the origin of replication RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Inhibition of DNA recombination at telomere Defective pyroptosis Negative Regulation of CDH1 Gene Transcription Amyloid fiber formation Chromatin modifications during the maternal to zygotic transition (MZT) MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Regulation of PD-L1(CD274) transcription
Drugs
Diseases
GWAS		Cognitive function ( 25644384) General cognitive ability ( 29844566) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Refractive error ( 32231278) Testicular germ cell tumor ( 23666239)
Interacting Genes		76 interacting genes: ANKRD11 APEX2 APTX AQP1 ARNT2 AXIN1 BASP1 BYSL CCDC33 CDC20B CDC7 CDK5RAP2 CDKL3 COPB1 CWF19L2 DDX6 DLGAP5 DSCAM DTNB DZIP1L ELOA ELOA2 EWSR1 FAM107A FAM124B FAM161A FAM50B FXR2 H2AC20 H2AC4 IKBKG KAT5 KIAA0408 KIF9 LTBR MAGEB18 MCM10 MCRS1 NGFR NUDT18 PABPC4 PBK PNKP PRC1 RASD1 RHPN1 RIBC2 RNF6 RPL9 RXRB SCNM1 SYTL4 TCEANC TNFRSF1B TRAF1 TRAF2 TRAF3 TRAF4 TRAF5 TRAF6 UBASH3A UBB UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2U ZBTB24 ZMAT2 ZNF329 ZNF417 ZNF587 ZNF655	72 interacting genes: ANP32A APP ATXN7L3 BAP1 BARD1 BMI1 BRCA1 CDY1 CEBPA CRP CSTF1 CTCFL DDB2 DNMT3L EIF2AK2 EP300 ESR1 FBL GATAD2A GATAD2B H2BC1 H4C14 HAT1 HDAC2 KAT2A KAT2B KAT5 KAT7 MSL2 MYSM1 NAA40 NAP1L4 NCAPH NCL NPM1 PARP10 PBRM1 PELP1 POT1 PRMT5 PRMT7 RAG1 RBBP4 RCC1 RNF168 RNF2 RNF20 RNF8 SART3 SIRT7 STK38 TAF15 TAF1A TAF1B TCF20 TRIM37 TSPY1 TSSK6 UBC UBE2B UBE2H UBR2 UIMC1 USP10 USP12 USP16 USP2 USP22 USP46 USP51 USP7 USP8
Entrez ID		4591	8338
HPRD ID		05463	09107
Ensembl ID		ENSG00000108395	ENSG00000184260
Uniprot IDs		O94972	Q16777
PDB IDs		3LRQ	6Y5E 7U0G 7U0I 7U0J 8DK5 8EVG 8EVH 8EVI 8EVJ 8SPS 8SPU 8SYP
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Nucleus Thioesterase Binding Protein K48-linked Ubiquitination Signaling Adaptor Activity Protein Polyubiquitination Tumor Necrosis Factor Receptor Binding Ubiquitin-protein Transferase Activity Ubiquitin Protein Ligase Binding CD40 Receptor Complex Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Macromolecule Metabolic Process Modification-dependent Protein Catabolic Process Zinc Ion Binding Protein Binding Protein Ubiquitination Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Polynucleotide 3'-phosphatase Activity Regulation Of Gene Expression Positive Regulation Of NF-kappaB Transcription Factor Activity Protein K11-linked Ubiquitination Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process DNA Damage Response Macromolecule Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Nucleoplasm Post-translational Protein Modification Regulation Of Canonical NF-kappaB Signal Transduction Protein Monoubiquitination Elongin Complex Tumor Necrosis Factor Receptor Superfamily Complex ISG15 Transferase Activity Positive Regulation Of Protein Ubiquitination Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of DNA-binding Transcription Factor Activity Ubiquitin Protein Ligase Activity Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Proteasomal Protein Catabolic Process Protein Autoubiquitination	Chromatin Organization Chromatin Remodeling Nucleus Histone Binding Nucleoplasm Epigenetic Regulation Of Gene Expression Chromatin Binding Chromosome Protein Modification Process Macromolecule Metabolic Process Post-translational Protein Modification Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Protein Metabolic Process Regulation Of RNA Metabolic Process Regulation Of DNA Repair Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Cellular Response To Stress Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Regulation Of Cell Cycle Regulation Of Primary Metabolic Process Regulation Of Gene Expression Histone H4 Acetyltransferase Activity Cysteine-type Deubiquitinase Activity Negative Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Histone H2A Deubiquitinase Activity Protein Deubiquitination Regulation Of DNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Histone Acetyltransferase Activity DNA Damage Response Protein Modification By Small Protein Removal Negative Regulation Of Biosynthetic Process Transferase Activity Nucleic Acid Metabolic Process DNA Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Cysteine-type Peptidase Activity Protein-containing Complex Positive Regulation Of DNA-templated Transcription
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