TRIM37 and BASP1

Number of citations: 0 (PubMedID 36961398)
Data Source: BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		TRIM37	BASP1
Name		tripartite motif containing 37	brain abundant membrane attached signal protein 1
Structure			No pdb structure
GO Annotations	Cellular Component	Chromosome Cytoplasm Peroxisome Peroxisomal Membrane Cytosol Membrane Aggresome ESC/E(Z) Complex Perinuclear Region Of Cytoplasm	Chromatin Nucleus Cytoplasm Cytoskeleton Plasma Membrane COP9 Signalosome Membrane Nuclear Matrix PML Body Nuclear Speck Cell Junction Growth Cone Vesicle Cell Projection Extracellular Exosome
	Molecular Function	Chromatin Binding Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Transferase Activity Enzyme Binding Ubiquitin Protein Ligase Binding Protein Homodimerization Activity Metal Ion Binding Ubiquitin Protein Ligase Activity Histone H2AK119 Ubiquitin Ligase Activity	Transcription Cis-regulatory Region Binding Transcription Corepressor Activity Protein Binding Calmodulin Binding Protein Domain Specific Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Monoubiquitination Protein Import Into Peroxisome Matrix Protein Ubiquitination Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of DNA-templated Transcription Negative Regulation Of Centriole Replication Protein Stabilization Protein Autoubiquitination Aggresome Assembly	Thorax And Anterior Abdomen Determination Gonad Development Substantia Nigra Development Negative Regulation Of DNA-templated Transcription Protein Homooligomerization Mesenchymal To Epithelial Transition Positive Regulation Of Heart Growth Diaphragm Development Metanephric Mesenchyme Development Podocyte Differentiation Supramolecular Fiber Organization Positive Regulation Of Metanephric Ureteric Bud Development
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	RHOF GTPase cycle
GWAS		Cognitive function ( 25644384 ) General cognitive ability ( 29844566 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Refractive error ( 32231278 ) Testicular germ cell tumor ( 23666239 )	Bipolar disorder with mood-incongruent psychosis ( 23092984 ) Melanoma ( 28212542 ) Obesity in adult survivors of childhood cancer exposed to cranial radiation ( 25963547 ) Plasma anti-thyroglobulin and anti-thyroid peroxidase levels (bivariate analysis) ( 29678681 )
Interacting Genes		76 interacting genes: ANKRD11 APEX2 APTX AQP1 ARNT2 AXIN1 BASP1 BYSL CCDC33 CDC20B CDC7 CDK5RAP2 CDKL3 COPB1 CWF19L2 DDX6 DLGAP5 DSCAM DTNB DZIP1L ELOA ELOA2 EWSR1 FAM107A FAM124B FAM161A FAM50B FXR2 H2AC20 H2AC4 IKBKG KAT5 KIAA0408 KIF9 LTBR MAGEB18 MCM10 MCRS1 NGFR NUDT18 PABPC4 PBK PNKP PRC1 RASD1 RHPN1 RIBC2 RNF6 RPL9 RXRB SCNM1 SYTL4 TCEANC TNFRSF1B TRAF1 TRAF2 TRAF3 TRAF4 TRAF5 TRAF6 UBASH3A UBB UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2U ZBTB24 ZMAT2 ZNF329 ZNF417 ZNF587 ZNF655	7 interacting genes: AGTR1 ATXN1 GAD1 GAD2 SERPINB5 SNCA TRIM37
Entrez ID		4591	10409
HPRD ID		05463	08389
Ensembl ID		ENSG00000108395	ENSG00000176788
Uniprot IDs		O94972	P80723
PDB IDs		3LRQ	Not available
GO Terms Enriched among Interactors		Ubiquitin Conjugating Enzyme Activity Nucleus Thioesterase Binding Protein K48-linked Ubiquitination Signaling Adaptor Activity Protein Polyubiquitination Tumor Necrosis Factor Receptor Binding Ubiquitin-protein Transferase Activity Ubiquitin Protein Ligase Binding CD40 Receptor Complex Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Macromolecule Metabolic Process Modification-dependent Protein Catabolic Process Zinc Ion Binding Protein Binding Protein Ubiquitination Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Polynucleotide 3'-phosphatase Activity Regulation Of Gene Expression Positive Regulation Of NF-kappaB Transcription Factor Activity Protein K11-linked Ubiquitination Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process DNA Damage Response Macromolecule Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Nucleoplasm Post-translational Protein Modification Regulation Of Canonical NF-kappaB Signal Transduction Protein Monoubiquitination Elongin Complex Tumor Necrosis Factor Receptor Superfamily Complex ISG15 Transferase Activity Positive Regulation Of Protein Ubiquitination Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of DNA-binding Transcription Factor Activity Ubiquitin Protein Ligase Activity Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Proteasomal Protein Catabolic Process Protein Autoubiquitination	Gamma-aminobutyrate Shunt Glutamate Decarboxylase Activity Gamma-aminobutyric Acid Biosynthetic Process L-glutamate Catabolic Process Gamma-aminobutyric Acid Metabolic Process Succinate Metabolic Process Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Carbon-carbon Lyase Activity Dicarboxylic Acid Catabolic Process Carboxy-lyase Activity Locomotory Behavior Glutamate Metabolic Process Trans-synaptic Signaling Social Behavior Pyridoxal Phosphate Binding Glutamine Family Amino Acid Metabolic Process Chemical Synaptic Transmission Axon Terminus Synaptic Signaling Excitatory Postsynaptic Potential Amino Acid Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Angiotensin Type I Receptor Activity Axon Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Proteinogenic Amino Acid Catabolic Process L-amino Acid Catabolic Process Adult Locomotory Behavior Dicarboxylic Acid Metabolic Process Monocarboxylic Acid Metabolic Process Regulation Of Postsynaptic Membrane Potential Bradykinin Receptor Binding Amino Acid Catabolic Process Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Phospholipase C-activating Angiotensin-activated Signaling Pathway Renin-angiotensin Regulation Of Aldosterone Production Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Negative Regulation Of Chaperone-mediated Autophagy Regulation Of Reactive Oxygen Species Metabolic Process Cell-cell Signaling Angiotensin Type II Receptor Activity Signaling Negative Regulation Of Cytoskeleton Organization