TRIM37 and FAM124B

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		TRIM37	FAM124B
Gene Name		tripartite motif containing 37	family with sequence similarity 124B
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Peroxisome Cytosol Aggresome ESC/E(Z) Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Chromatin Binding Ubiquitin-protein Transferase Activity Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Ligase Activity Ubiquitin Protein Ligase Binding Protein Homodimerization Activity Ubiquitin Protein Ligase Activity	Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of NF-kappaB Transcription Factor Activity Histone H2A Monoubiquitination Histone H2A-K119 Monoubiquitination Negative Regulation Of Centriole Replication Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Autoubiquitination Aggresome Assembly
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS		Testicular germ cell tumor ( 23666239)
Protein-Protein Interactions		59 interactors: ANKRD11 APEX2 APTX ARNT2 BYSL CCDC33 CDC20B CDK5RAP2 COPB1 CWF19L2 DDX6 DLGAP5 EWSR1 FAM107A FAM124B FAM161A FAM50B FXR2 KAT5 KIAA0408 KIF9 LTBR MAGEB18 MCM10 MCRS1 NGFR NUDT18 PBK PNKP PRC1 RASD1 RHPN1 RIBC2 RPL9 SCNM1 SSX2IP TANK TCEB3B TNFRSF1B TRAF1 TRAF2 TRAF3 TRAF4 TRAF5 TRAF6 UBASH3A UBB UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2U ZMAT2 ZNF329 ZNF417 ZNF655	29 interactors: ADAMTSL4 AES BIRC7 CARD9 CCDC85B EFEMP2 GOLGA2 KCTD6 KCTD9 KIAA1958 KRT19 KRT31 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-9 KRTAP5-9 LZTS2 MDFI MKRN3 NOTCH2NL RBPMS RINT1 SSX2IP TCF4 TRIM37 TRIM54 TRIP6 USHBP1
Entrez ID		4591	79843
HPRD ID		05463	08663
Ensembl ID		ENSG00000108395	ENSG00000124019
Uniprot IDs		A8K0V9 A8K8U4 F8WEE6 O94972	Q9H5Z6
PDB IDs		3LRQ
Enriched GO Terms of Interacting Partners?		Protein Polyubiquitination TRIF-dependent Toll-like Receptor Signaling Pathway Protein K48-linked Ubiquitination MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Protein Ubiquitination Protein Modification By Small Protein Conjugation Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Cellular Macromolecule Catabolic Process Regulation Of Innate Immune Response Protein K11-linked Ubiquitination Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Protein K63-linked Ubiquitination Cellular Response To Stress Catabolic Process Polynucleotide 3' Dephosphorylation Apoptotic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Protein Catabolic Process Immune Response-regulating Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of DNA-templated Transcription In Response To Stress Programmed Cell Death I-kappaB Kinase/NF-kappaB Signaling Regulation Of Mitotic Cell Cycle Phase Transition Cellular Response To DNA Damage Stimulus Regulation Of Cell Cycle Phase Transition Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteolysis Cell Death Death Activation Of NF-kappaB-inducing Kinase Activity Modification-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of NIK/NF-kappaB Signaling Cellular Protein Catabolic Process DNA Repair Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Proteolysis Regulation Of Stress-activated MAPK Cascade NIK/NF-kappaB Signaling Regulation Of NIK/NF-kappaB Signaling Regulation Of Metabolic Process	Negative Regulation Of Wnt Signaling Pathway Regulation Of Protein Localization To Nucleus Regulation Of Nucleocytoplasmic Transport Regulation Of Intracellular Transport Regulation Of Binding Regulation Of Intracellular Protein Transport Negative Regulation Of Binding Regulation Of Signal Transduction Positive Regulation Of Nucleocytoplasmic Transport Regulation Of Wnt Signaling Pathway Positive Regulation Of JNK Cascade Cellular Component Assembly Regulation Of Signaling Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of Cellular Localization Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Protein Binding Cell Differentiation Involved In Embryonic Placenta Development Positive Regulation Of Intracellular Protein Transport Regulation Of JNK Cascade Activation Of JUN Kinase Activity Regulation Of Protein Import Into Nucleus Regulation Of Stress-activated MAPK Cascade Regulation Of Protein Localization Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Natural Killer Cell Apoptotic Process Regulation Of Signal Transduction Involved In Mitotic G2 DNA Damage Checkpoint Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Protein Binding Positive Regulation Of Intracellular Transport Negative Regulation Of Fat Cell Differentiation Catenin Import Into Nucleus Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of JUN Kinase Activity Wnt Signaling Pathway Regulation Of Protein Transport Negative Regulation Of Protein Localization To Nucleus Regulation Of JUN Kinase Activity Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Histone H2A-K119 Monoubiquitination JNK Cascade Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Transcription Factor Import Into Nucleus Regulation Of Establishment Of Protein Localization Negative Regulation Of RNA Biosynthetic Process Maintenance Of DNA Repeat Elements
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