TRIM37 and MAGEB18

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		TRIM37	MAGEB18
Gene Name		tripartite motif containing 37	melanoma antigen family B, 18
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Peroxisome Cytosol Aggresome ESC/E(Z) Complex Perinuclear Region Of Cytoplasm	Cytoplasm
	Molecular Function	Chromatin Binding Ubiquitin-protein Transferase Activity Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Ligase Activity Ubiquitin Protein Ligase Binding Protein Homodimerization Activity Ubiquitin Protein Ligase Activity	Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of NF-kappaB Transcription Factor Activity Histone H2A Monoubiquitination Histone H2A-K119 Monoubiquitination Negative Regulation Of Centriole Replication Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Autoubiquitination Aggresome Assembly
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS		Testicular germ cell tumor ( 23666239)	Erectile dysfunction and prostate cancer treatment ( 20932654)
Protein-Protein Interactions		59 interactors: ANKRD11 APEX2 APTX ARNT2 BYSL CCDC33 CDC20B CDK5RAP2 COPB1 CWF19L2 DDX6 DLGAP5 EWSR1 FAM107A FAM124B FAM161A FAM50B FXR2 KAT5 KIAA0408 KIF9 LTBR MAGEB18 MCM10 MCRS1 NGFR NUDT18 PBK PNKP PRC1 RASD1 RHPN1 RIBC2 RPL9 SCNM1 SSX2IP TANK TCEB3B TNFRSF1B TRAF1 TRAF2 TRAF3 TRAF4 TRAF5 TRAF6 UBASH3A UBB UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2U ZMAT2 ZNF329 ZNF417 ZNF655	8 interactors: ATXN1 CTAGE5 GABPB1 HTT LNX1 TNIP1 TP53 TRIM37
Entrez ID		4591	286514
HPRD ID		05463	06647
Ensembl ID		ENSG00000108395	ENSG00000176774
Uniprot IDs		A8K0V9 A8K8U4 F8WEE6 O94972	Q96M61
PDB IDs		3LRQ
Enriched GO Terms of Interacting Partners?		Protein Polyubiquitination TRIF-dependent Toll-like Receptor Signaling Pathway Protein K48-linked Ubiquitination MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Protein Ubiquitination Protein Modification By Small Protein Conjugation Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Cellular Macromolecule Catabolic Process Regulation Of Innate Immune Response Protein K11-linked Ubiquitination Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Protein K63-linked Ubiquitination Cellular Response To Stress Catabolic Process Polynucleotide 3' Dephosphorylation Apoptotic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Protein Catabolic Process Immune Response-regulating Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of DNA-templated Transcription In Response To Stress Programmed Cell Death I-kappaB Kinase/NF-kappaB Signaling Regulation Of Mitotic Cell Cycle Phase Transition Cellular Response To DNA Damage Stimulus Regulation Of Cell Cycle Phase Transition Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteolysis Cell Death Death Activation Of NF-kappaB-inducing Kinase Activity Modification-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of NIK/NF-kappaB Signaling Cellular Protein Catabolic Process DNA Repair Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Proteolysis Regulation Of Stress-activated MAPK Cascade NIK/NF-kappaB Signaling Regulation Of NIK/NF-kappaB Signaling Regulation Of Metabolic Process	Determination Of Adult Lifespan Regulation Of Mitochondrial Membrane Permeability Positive Regulation Of Gene Expression Regulation Of Membrane Permeability Nucleocytoplasmic Transport Multicellular Organismal Aging Nuclear Transport Negative Regulation Of Neural Precursor Cell Proliferation Regulation Of Transcription From RNA Polymerase II Promoter Neuron Apoptotic Process Response To Light Stimulus Mitochondrial Membrane Organization Visual Learning Positive Regulation Of Metabolic Process Neuron Death Positive Regulation Of Transcription From RNA Polymerase II Promoter Visual Behavior Mitochondrion Organization Cell Aging Negative Regulation Of Signal Transduction Protein Oligomerization Associative Learning Neural Plate Formation Modulation By Symbiont Of Host I-kappaB Kinase/NF-kappaB Cascade Response To Radiation Negative Regulation Of Signaling Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Macromitophagy Serotonin Uptake Oligodendrocyte Apoptotic Process Lactate Biosynthetic Process From Pyruvate Protein Import Into Nucleus Nuclear Import Behavior Regulation Of Phosphorus Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Learning Negative Regulation Of Cerebellar Granule Cell Precursor Proliferation Negative Regulation Of Helicase Activity Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Regulation Of Protein Phosphatase Type 2A Activity Histone H2A-K119 Monoubiquitination Mitochondrial Transport Protein Import Positive Regulation Of Cellular Biosynthetic Process Cytoplasmic Transport Quinolinate Biosynthetic Process Negative Regulation Of Synaptic Transmission, Dopaminergic Protein Localization To Nucleus
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