TRIM37 and UBE2E2

Number of citations of the paper that reports this interaction (PMID 21143188)
10

Data Source:
BioGRID (two hybrid)

		TRIM37	UBE2E2
Gene Name		tripartite motif containing 37	ubiquitin-conjugating enzyme E2E 2
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Gene Ontology Annotations	Cellular Component	Cytoplasm Peroxisome Cytosol Aggresome ESC/E(Z) Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Chromatin Binding Ubiquitin-protein Transferase Activity Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Ligase Activity Ubiquitin Protein Ligase Binding Protein Homodimerization Activity Ubiquitin Protein Ligase Activity	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ligase Activity ISG15 Transferase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of NF-kappaB Transcription Factor Activity Histone H2A Monoubiquitination Histone H2A-K119 Monoubiquitination Negative Regulation Of Centriole Replication Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Autoubiquitination Aggresome Assembly	Cellular Response To DNA Damage Stimulus ISG15-protein Conjugation Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System	Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS		Testicular germ cell tumor ( 23666239)
Protein-Protein Interactions		59 interactors: ANKRD11 APEX2 APTX ARNT2 BYSL CCDC33 CDC20B CDK5RAP2 COPB1 CWF19L2 DDX6 DLGAP5 EWSR1 FAM107A FAM124B FAM161A FAM50B FXR2 KAT5 KIAA0408 KIF9 LTBR MAGEB18 MCM10 MCRS1 NGFR NUDT18 PBK PNKP PRC1 RASD1 RHPN1 RIBC2 RPL9 SCNM1 SSX2IP TANK TCEB3B TNFRSF1B TRAF1 TRAF2 TRAF3 TRAF4 TRAF5 TRAF6 UBASH3A UBB UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2U ZMAT2 ZNF329 ZNF417 ZNF655	61 interactors: APP ARIH1 ARIH2 ARRDC3 BARD1 BRCA1 CHFR CUL3 CUL9 DAZAP2 DTX3 DTX3L DZIP3 FAM9B FHL1 IPO11 ISG15 MARCH3 MDM2 MID1 MID2 MKRN3 MUL1 NFE2L2 PCGF2 PRAM1 RING1 RLIM RNF10 RNF103 RNF11 RNF111 RNF114 RNF125 RNF14 RNF166 RNF185 RNF19A RNF2 RNF25 RNF4 RNF5 RNF8 SRPK1 SRPK2 STUB1 TRIM2 TRIM23 TRIM27 TRIM28 TRIM31 TRIM32 TRIM37 TRIM38 TRIM39 TRIM45 TRIM50 UBA1 UBOX5 XIAP ZNRF1
Entrez ID		4591	7325
HPRD ID		05463	06779
Ensembl ID		ENSG00000108395
Uniprot IDs		A8K0V9 A8K8U4 F8WEE6 O94972	Q96LR5
PDB IDs		3LRQ	1Y6L
Enriched GO Terms of Interacting Partners?		Protein Polyubiquitination TRIF-dependent Toll-like Receptor Signaling Pathway Protein K48-linked Ubiquitination MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Protein Ubiquitination Protein Modification By Small Protein Conjugation Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Cellular Macromolecule Catabolic Process Regulation Of Innate Immune Response Protein K11-linked Ubiquitination Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Protein K63-linked Ubiquitination Cellular Response To Stress Catabolic Process Polynucleotide 3' Dephosphorylation Apoptotic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Protein Catabolic Process Immune Response-regulating Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of DNA-templated Transcription In Response To Stress Programmed Cell Death I-kappaB Kinase/NF-kappaB Signaling Regulation Of Mitotic Cell Cycle Phase Transition Cellular Response To DNA Damage Stimulus Regulation Of Cell Cycle Phase Transition Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteolysis Cell Death Death Activation Of NF-kappaB-inducing Kinase Activity Modification-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of NIK/NF-kappaB Signaling Cellular Protein Catabolic Process DNA Repair Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Proteolysis Regulation Of Stress-activated MAPK Cascade NIK/NF-kappaB Signaling Regulation Of NIK/NF-kappaB Signaling Regulation Of Metabolic Process	Protein Ubiquitination Protein Modification By Small Protein Conjugation Cellular Protein Modification Process Cellular Protein Metabolic Process Protein Metabolic Process Protein Polyubiquitination Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Cellular Metabolic Process Negative Regulation Of Viral Process Protein Autoubiquitination Catabolic Process Regulation Of Viral Process Proteolysis Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Regulation Of Viral Release From Host Cell Metabolic Process Histone Ubiquitination Negative Regulation Of Cellular Metabolic Process Histone H2A Ubiquitination Innate Immune Response Negative Regulation Of Viral Release From Host Cell Protein Monoubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Histone Monoubiquitination Proteasomal Protein Catabolic Process Negative Regulation Of Viral Transcription Response To Stress Regulation Of Protein Ubiquitination Protein K6-linked Ubiquitination Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Immune Response Regulation Of Cell Cycle Negative Regulation Of Gene Expression Negative Regulation Of RNA Biosynthetic Process Histone H2A Monoubiquitination Histone H2A-K119 Monoubiquitination Cellular Response To Stress Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Defense Response Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Gene Expression
Tagcloud ?			3p24 amino assigned bond cdna conjugating drosophila e1 encoding enzyme extension fluorescence formed hybridization identity kb product shares similarity thioester transcribed transcript ubc ubcd2 ubch6 ubch8 ubcm2 ubiquitin
Tagcloud (Difference) ?			3p24 amino assigned bond cdna conjugating drosophila e1 encoding enzyme extension fluorescence formed hybridization identity kb product shares similarity thioester transcribed transcript ubc ubcd2 ubch6 ubch8 ubcm2 ubiquitin
Tagcloud (Intersection) ?