TRIM37 and RNF6

Number of citations of the paper that reports this interaction (PubMedID 26871637)
43

Data Source:
BioGRID (two hybrid)

		TRIM37	RNF6
Description		tripartite motif containing 37	ring finger protein 6
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome Cytoplasm Peroxisome Peroxisomal Membrane Cytosol Membrane Aggresome ESC/E(Z) Complex Perinuclear Region Of Cytoplasm	Nucleus Cytoplasm PML Body Axon Nuclear Membrane Cell Projection
	Molecular Function	Chromatin Binding Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Transferase Activity Enzyme Binding Ubiquitin Protein Ligase Binding Protein Homodimerization Activity Metal Ion Binding Ubiquitin Protein Ligase Activity Histone H2AK119 Ubiquitin Ligase Activity	DNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Nuclear Androgen Receptor Binding Ubiquitin Protein Ligase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Monoubiquitination Protein Import Into Peroxisome Matrix Protein Ubiquitination Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of DNA-templated Transcription Negative Regulation Of Centriole Replication Protein Stabilization Protein Autoubiquitination Aggresome Assembly	Regulation Of DNA-templated Transcription Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Negative Regulation Of Axon Extension Protein K27-linked Ubiquitination Positive Regulation Of DNA-templated Transcription Axon Extension Regulation Of Androgen Receptor Signaling Pathway Protein K48-linked Ubiquitination Protein K6-linked Ubiquitination
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Cognitive function ( 25644384) General cognitive ability ( 29844566) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Refractive error ( 32231278) Testicular germ cell tumor ( 23666239)	Sporadic pituitary adenoma ( 26029870) Type 2 diabetes ( 24509480 28869590 30297969 30718926 32499647) Urate levels (BMI interaction) ( 25811787)
Interacting Genes		76 interacting genes: ANKRD11 APEX2 APTX AQP1 ARNT2 AXIN1 BASP1 BYSL CCDC33 CDC20B CDC7 CDK5RAP2 CDKL3 COPB1 CWF19L2 DDX6 DLGAP5 DSCAM DTNB DZIP1L ELOA ELOA2 EWSR1 FAM107A FAM124B FAM161A FAM50B FXR2 H2AC20 H2AC4 IKBKG KAT5 KIAA0408 KIF9 LTBR MAGEB18 MCM10 MCRS1 NGFR NUDT18 PABPC4 PBK PNKP PRC1 RASD1 RHPN1 RIBC2 RNF6 RPL9 RXRB SCNM1 SYTL4 TCEANC TNFRSF1B TRAF1 TRAF2 TRAF3 TRAF4 TRAF5 TRAF6 UBASH3A UBB UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2U ZBTB24 ZMAT2 ZNF329 ZNF417 ZNF587 ZNF655	39 interacting genes: AHCYL1 AR CBY2 CCDC33 CCDC57 CDKN1B CEP70 GOLGA2 HOOK2 IKZF1 IKZF3 KIAA0753 KRT15 KRT40 LDOC1 MAGED1 MDFI MEOX2 MID2 MIPOL1 MTUS2 PNMA2 REL RINT1 RPGRIP1 SSX2IP STK4 STX11 TADA2A TFIP11 TNS2 TP53 TRIM23 TRIM27 TRIM37 TSGA10 UBE2C UBE2D1 UBE2H
Entrez ID		4591	6049
HPRD ID		05463	05027
Ensembl ID		ENSG00000108395	ENSG00000127870
Uniprot IDs		O94972	A0A024RDP2 A0A0S2Z4G9 Q9Y252
PDB IDs		3LRQ
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Nucleus Thioesterase Binding Protein K48-linked Ubiquitination Signaling Adaptor Activity Protein Polyubiquitination Tumor Necrosis Factor Receptor Binding Ubiquitin-protein Transferase Activity Ubiquitin Protein Ligase Binding CD40 Receptor Complex Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Macromolecule Metabolic Process Modification-dependent Protein Catabolic Process Zinc Ion Binding Protein Binding Protein Ubiquitination Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Polynucleotide 3'-phosphatase Activity Regulation Of Gene Expression Positive Regulation Of NF-kappaB Transcription Factor Activity Protein K11-linked Ubiquitination Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process DNA Damage Response Macromolecule Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Nucleoplasm Post-translational Protein Modification Regulation Of Canonical NF-kappaB Signal Transduction Protein Monoubiquitination Elongin Complex Tumor Necrosis Factor Receptor Superfamily Complex ISG15 Transferase Activity Positive Regulation Of Protein Ubiquitination Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of DNA-binding Transcription Factor Activity Ubiquitin Protein Ligase Activity Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Proteasomal Protein Catabolic Process Protein Autoubiquitination	Identical Protein Binding Intracellular Transport Cytoskeleton Ubiquitin-protein Transferase Activity Microtubule Organizing Center Organization Cytoplasm Protein Binding Cellular Localization Establishment Of Localization In Cell Centrosome Ubiquitin Conjugating Enzyme Activity Ubiquitin Protein Ligase Activity Cell Projection Assembly Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Cellular Response To Antibiotic Cilium Assembly Negative Regulation Of Epithelial Cell Proliferation Intracellular Protein Localization Protein Ubiquitination Transcription Coactivator Activity Cilium Organization Protein Transport Negative Regulation Of Viral Transcription Regulation Of Exit From Mitosis Suppression Of Viral Release By Host Protein Modification By Small Protein Conjugation Organelle Organization Regulation Of Viral Transcription Organelle Assembly Negative Regulation Of Cell Population Proliferation Intracellular Protein Transport Protein Tetramerization Cell Differentiation Involved In Embryonic Placenta Development Plasma Membrane Bounded Cell Projection Assembly
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?