TRIM37 and APEX2

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		TRIM37	APEX2
Gene Name		tripartite motif containing 37	APEX nuclease (apurinic/apyrimidinic endonuclease) 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Peroxisome Cytosol Aggresome ESC/E(Z) Complex Perinuclear Region Of Cytoplasm	Nucleus Nucleolus Mitochondrial Inner Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Chromatin Binding Ubiquitin-protein Transferase Activity Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Ligase Activity Ubiquitin Protein Ligase Binding Protein Homodimerization Activity Ubiquitin Protein Ligase Activity	DNA Binding DNA-(apurinic Or Apyrimidinic Site) Lyase Activity Zinc Ion Binding Double-stranded DNA 3'-5' Exodeoxyribonuclease Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of NF-kappaB Transcription Factor Activity Histone H2A Monoubiquitination Histone H2A-K119 Monoubiquitination Negative Regulation Of Centriole Replication Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Autoubiquitination Aggresome Assembly	DNA Catabolic Process, Endonucleolytic DNA Catabolic Process, Exonucleolytic Base-excision Repair DNA Recombination Cell Cycle
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS		Testicular germ cell tumor ( 23666239)
Protein-Protein Interactions		59 interactors: ANKRD11 APEX2 APTX ARNT2 BYSL CCDC33 CDC20B CDK5RAP2 COPB1 CWF19L2 DDX6 DLGAP5 EWSR1 FAM107A FAM124B FAM161A FAM50B FXR2 KAT5 KIAA0408 KIF9 LTBR MAGEB18 MCM10 MCRS1 NGFR NUDT18 PBK PNKP PRC1 RASD1 RHPN1 RIBC2 RPL9 SCNM1 SSX2IP TANK TCEB3B TNFRSF1B TRAF1 TRAF2 TRAF3 TRAF4 TRAF5 TRAF6 UBASH3A UBB UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2U ZMAT2 ZNF329 ZNF417 ZNF655	11 interactors: APP CALCOCO2 CCDC85B EFEMP2 HOOK2 NEDD4L NINL PCNA PGR TRAF2 TRIM37
Entrez ID		4591	27301
HPRD ID		05463	06442
Ensembl ID		ENSG00000108395
Uniprot IDs		A8K0V9 A8K8U4 F8WEE6 O94972	B4DWI9 B7ZA71 E5KN95 Q9UBZ4
PDB IDs		3LRQ
Enriched GO Terms of Interacting Partners?		Protein Polyubiquitination TRIF-dependent Toll-like Receptor Signaling Pathway Protein K48-linked Ubiquitination MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Protein Ubiquitination Protein Modification By Small Protein Conjugation Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Cellular Macromolecule Catabolic Process Regulation Of Innate Immune Response Protein K11-linked Ubiquitination Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Protein K63-linked Ubiquitination Cellular Response To Stress Catabolic Process Polynucleotide 3' Dephosphorylation Apoptotic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Protein Catabolic Process Immune Response-regulating Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of DNA-templated Transcription In Response To Stress Programmed Cell Death I-kappaB Kinase/NF-kappaB Signaling Regulation Of Mitotic Cell Cycle Phase Transition Cellular Response To DNA Damage Stimulus Regulation Of Cell Cycle Phase Transition Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteolysis Cell Death Death Activation Of NF-kappaB-inducing Kinase Activity Modification-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of NIK/NF-kappaB Signaling Cellular Protein Catabolic Process DNA Repair Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Proteolysis Regulation Of Stress-activated MAPK Cascade NIK/NF-kappaB Signaling Regulation Of NIK/NF-kappaB Signaling Regulation Of Metabolic Process	Protein Monoubiquitination Protein Autoubiquitination Positive Regulation Of Deoxyribonuclease Activity Regulation Of Transcription From RNA Polymerase II Promoter Leading Strand Elongation Synaptic Growth At Neuromuscular Junction Tertiary Branching Involved In Mammary Gland Duct Morphogenesis Positive Regulation Of Caveolin-mediated Endocytosis Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Response To Inorganic Substance Regulation Of RNA Metabolic Process Collateral Sprouting In Absence Of Injury Histone H2A-K119 Monoubiquitination Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Ubiquitination Regulation Of Protein Binding Positive Regulation Of Peptidase Activity Cell Maturation Response To Stress Collateral Sprouting Axon Midline Choice Point Recognition Negative Regulation Of Gene Expression Regulation Of Gene Expression Protein Modification By Small Protein Conjugation Regulation Of Nitrogen Compound Metabolic Process Progesterone Receptor Signaling Pathway Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Negative Regulation Of Centriole Replication Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Caveolin-mediated Endocytosis Transcription Initiation From RNA Polymerase II Promoter Protein Polyubiquitination Axon Choice Point Recognition Negative Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Glial Cell Apoptotic Process Cellular Homeostasis Response To Organic Substance Intracellular Receptor Signaling Pathway Negative Regulation Of Protein Localization To Cell Surface Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Regulation Of Tight Junction Assembly Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Neuron Remodeling Positive Regulation Of Protein Homodimerization Activity Mammary Gland Branching Involved In Pregnancy DNA-templated Transcription, Initiation Negative Regulation Of Sodium Ion Transport Translesion Synthesis
Tagcloud ?			applications catalytic display efficiency electron enabling endoplasmic engineered enrichment evolution far labeling live localization microscopy micu1 permits peroxidase precludes promiscuous proteomics requiring resolve reticulum submitochondrial superior tag yeast
Tagcloud (Difference) ?			applications catalytic display efficiency electron enabling endoplasmic engineered enrichment evolution far labeling live localization microscopy micu1 permits peroxidase precludes promiscuous proteomics requiring resolve reticulum submitochondrial superior tag yeast
Tagcloud (Intersection) ?